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Co-localization of μ opioid receptor is greater with dynorphin than enkephalin in rat striatum

Autor: Henri Klop, Nicole D. Guttenberg, Masabumi Minami, Pieter Voorn, Masamichi Satoh

Publikováno v: NeuroReport. 7:2119-2124

Using a combination of radioactive and non-radioactive in situ hybridization, the mu opioid receptor mRNA was localized in enkephalin as well as dynorphin neurones of the rat striatum. The proportion of enkephalin neurones showing co-localized mu opi

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::372d7da6467b22874e99f89540fcff06
https://doi.org/10.1097/00001756-199609020-00011

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Structure-based lead identification of ATP-competitive MK2 inhibitors

Autor: Judith Versteegh, Nicole Seegers, Henri Klop, Tjeerd Barf, Claudia Hofstra, Jeroen A.D.M. de Roos, Carsten Schultz-Fademrecht, Mario van Zeeland, Arthur Oubrie, Bert Kazemier, Maaike van Hoek, Dennis Demont, Allard Kaptein, Jorrit J. Hornberg, Sander de Wilde, Ruben L. Smeets, Bas van de Kar, Ruud van der Heijden, Richard van Someren

Publikováno v: Bioorganic & Medicinal Chemistry Letters, 21, 3818-22
Bioorganic & Medicinal Chemistry Letters, 21, 12, pp. 3818-22

Item does not contain fulltext MK2 kinase is a promising drug discovery target for the treatment of inflammatory diseases. Here, we describe the discovery of novel MK2 inhibitors using X-ray crystallography and structure-based drug design. The lead h

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1bdeec28829a3848ff7f20ab076a3584
http://hdl.handle.net/2066/97376

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Molecular pathway profiling of T lymphocyte signal transduction pathways; Th1 and Th2 genomic fingerprints are defined by TCR and CD28-mediated signaling

Autor: Sussane Bauerschmidt, Wilco W. M. Fleuren, Anja Garritsen, Monika Gorecka, Irma Joosten, Wynand Alkema, Paul Vink, Xuehui He, Ruben L. Smeets, Frank Wijnands, Annemieke M. H. Boots, Henri Klop, Hans J. P. M. Koenen

Publikováno v: Bmc immunology, 13:12
BMC Immunology, 13, 12-12
BMC Immunology
BMC Immunology, 13, pp. 12-12
BMC Immunology, Vol 13, Iss 1, p 12 (2012)
Molecular Immunology, 13. Pergamon Press

Contains fulltext : 108719.pdf (Publisher’s version ) (Open Access) BACKGROUND: T lymphocytes are orchestrators of adaptive immunity. Naive T cells may differentiate into Th1, Th2, Th17 or iTreg phenotypes, depending on environmental co-stimulatory

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::92288b149c5e9e9891a0b8a6ee643936
https://hdl.handle.net/2066/108719

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