Zobrazeno 1 - 10
of 70
pro vyhledávání: '"Henri J Huttunen"'
Autor:
Melissa A. Graewert, Maria Volkova, Klara Jonasson, Juha A. E. Määttä, Tobias Gräwert, Samara Mamidi, Natalia Kulesskaya, Johan Evenäs, Richard E. Johnsson, Dmitri Svergun, Arnab Bhattacharjee, Henri J. Huttunen
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-13 (2024)
Abstract Cerebral dopamine neurotrophic factor (CDNF) is an unconventional neurotrophic factor that is a disease-modifying drug candidate for Parkinson’s disease. CDNF has pleiotropic protective effects on stressed cells, but its mechanism of actio
Externí odkaz:
https://doaj.org/article/96e49cedbeaa44d2becdda52aada34c8
Autor:
Prasanna eSakha, Aino eVesikansa, Ester eOrav, Joonas eHeikkinen, Tiina-Kaisa eKukko-Lukjanov, Alexandra eShintyapina, Sami eFranssila, Ville eJokinen, Henri J Huttunen, Sari E Lauri
Publikováno v:
Frontiers in Cellular Neuroscience, Vol 10 (2016)
Kainate type of glutamate receptors (KARs) are highly expressed during early brain development and may influence refinement of the circuitry via modulating synaptic transmission and plasticity. KARs are also localized to axons, however, their exact r
Externí odkaz:
https://doaj.org/article/bc94353a2a904efca72e513d90ca2abe
Publikováno v:
PLoS ONE, Vol 9, Iss 9, p e107129 (2014)
The global incidence of metabolic and age-related diseases, including type 2 diabetes and Alzheimer's disease, is on the rise. In addition to traditional pharmacotherapy, drug candidates from complementary and alternative medicine are actively being
Externí odkaz:
https://doaj.org/article/ba4e21fbdf994845a9c52102709554e6
Autor:
Maria Merezhko, Pranuthi Muggalla, Niko-Petteri Nykänen, Xu Yan, Prasanna Sakha, Henri J Huttunen
Publikováno v:
PLoS ONE, Vol 9, Iss 6, p e98619 (2014)
Amyloid-β precursor protein (APP) plays a central role in pathogenesis of Alzheimer's disease. APP has a short half-life and undergoes complex proteolytic processing that is highly responsive to various stimuli such as changes in cellular lipid or e
Externí odkaz:
https://doaj.org/article/3ef70c38ce114ebdb4ad62b2be0d6b4a
Autor:
Kuan-Yin Tseng, Vassilis Stratoulias, Wei-Fen Hu, Jui-Sheng Wu, Vicki Wang, Yuan-Hao Chen, Anna Seelbach, Henri J. Huttunen, Natalia Kulesskaya, Cheng-Yoong Pang, Jian-Liang Chou, Maria Lindahl, Mart Saarma, Li-Chuan Huang, Mikko Airavaara, Hock-Kean Liew
Publikováno v:
Cell Death and Disease, Vol 14, Iss 2, Pp 1-20 (2023)
Abstract During intracerebral hemorrhage (ICH), hematoma formation at the site of blood vessel damage results in local mechanical injury. Subsequently, erythrocytes lyse to release hemoglobin and heme, which act as neurotoxins and induce inflammation
Externí odkaz:
https://doaj.org/article/e5091f6de8f64d6aa9ee0c7414b369b1
Publikováno v:
Neural Regeneration Research, Vol 20, Iss 4, Pp 1094-1095 (2025)
Externí odkaz:
https://doaj.org/article/95972a5ee77e4636a7affc0a3d6f946b
Autor:
Henri J. Huttunen, Mart Saarma
Publikováno v:
Cell Transplantation, Vol 28 (2019)
Neurotrophic factors (NTF) are a subgroup of growth factors that promote survival and differentiation of neurons. Due to their neuroprotective and neurorestorative properties, their therapeutic potential has been tested in various neurodegenerative d
Externí odkaz:
https://doaj.org/article/29daf89731b44eaf92deacb85d31cf3b
Autor:
Henri J. Huttunen, Sigrid Booms, Magnus Sjögren, Vera Kerstens, Jarkko Johansson, Rebecka Holmnäs, Jani Koskinen, Natalia Kulesskaya, Patrik Fazio, Max Woolley, Alan Brady, Julia Williams, David Johnson, Narges Dailami, William Gray, Reeta Levo, Mart Saarma, Christer Halldin, Johan Marjamaa, Julio Resendiz‐Nieves, Irena Grubor, Göran Lind, Johanna Eerola‐Rautio, Tuomas Mertsalmi, Mattias Andréasson, Gesine Paul, Juha Rinne, Riku Kivisaari, Hjalmar Bjartmarz, Per Almqvist, Andrea Varrone, Filip Scheperjans, Håkan Widner, Per Svenningsson
Publikováno v:
Movement Disorders.
Background: Cerebral dopamine neurotrophic factor (CDNF) is an unconventional neurotrophic factor that protects dopamine neurons and improves motor function in animal models of Parkinson's disease (PD). Objective: The primary objectives of this study
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::edb5fd2ecb02daa82407bd5209aaa571
https://doi.org/10.1002/mds.29426
https://doi.org/10.1002/mds.29426
Autor:
Tony S. Eteläinen, M. Catarina Silva, Johanna K. Uhari-Väänänen, Francesca De Lorenzo, Maria H. Jäntti, Hengjing Cui, Marta Chavero-Pieres, Tommi Kilpeläinen, Christina Mechtler, Reinis Svarcbahs, Erin Seppälä, Juha R. Savinainen, Elena Puris, Gert Fricker, Mikko Gynther, Ulrika H. Julku, Henri J. Huttunen, Stephen J. Haggarty, Timo T. Myöhänen
Publikováno v:
Science Translational Medicine. 15
Tauopathies are neurodegenerative diseases that are characterized by accumulation of hyperphosphorylated tau protein, higher-order aggregates, and tau filaments. Protein phosphatase 2A (PP2A) is a major tau dephosphorylating phosphatase, and a decrea
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::28a67c6acc03a5f4f7c73bb13facb20c
https://doi.org/10.1126/scitranslmed.abq2915
https://doi.org/10.1126/scitranslmed.abq2915
Autor:
Claudio Rivera, Sung I. Kim, Ville Jokinen, Sebnem Kesaf, Henri J. Huttunen, Christophe Pellegrino, Jeon G. Han, Tatiana Sukhanova, Anastasia Ludwig, Florence Molinari, Sari E. Lauri, Joonas J. Heikkinen, Shokoufeh Khakipoor, Sami Franssila
Publikováno v:
Scientific Reports, Vol 10, Iss 1, Pp 1-9 (2020)
Scientific Reports
Scientific Reports, Nature Publishing Group, 2020, 10 (1), ⟨10.1038/s41598-020-74535-6⟩
Scientific Reports
Scientific Reports, Nature Publishing Group, 2020, 10 (1), ⟨10.1038/s41598-020-74535-6⟩
International audience; Different types of carbon materials are biocompatible with neural cells and can promote maturation. The mechanism of this effect is not clear. Here we have tested the capacity of a carbon material composed of amorphous sp 3 ca
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::70740b7acf6b50a650dcaf550f7d0d4f
http://link.springer.com/article/10.1038/s41598-020-74535-6
http://link.springer.com/article/10.1038/s41598-020-74535-6