Zobrazeno 1 - 10
of 77
pro vyhledávání: '"Henri Chahinian"'
Publikováno v:
International Journal of Molecular Sciences, Vol 25, Iss 18, p 10194 (2024)
Serotonin is distinct among synaptic neurotransmitters because it is amphipathic and released from synaptic vesicles at concentrations superior to its water solubility limit (270 mM in synaptic vesicles for a solubility limit of 110 mM). Hence, serot
Externí odkaz:
https://doaj.org/article/0e15f7b6d49e45f89f785df0cb6b375c
Publikováno v:
International Journal of Molecular Sciences, Vol 25, Iss 16, p 8583 (2024)
The synapse is a piece of information transfer machinery replacing the electrical conduction of nerve impulses at the end of the neuron. Like many biological mechanisms, its functioning is heavily affected by time constraints. The solution selected b
Externí odkaz:
https://doaj.org/article/fec7ecf030644a368335732051d3353b
Publikováno v:
Life, Vol 14, Iss 3, p 280 (2024)
Defining life is an arduous task that has puzzled philosophers and scientists for centuries. Yet biology suffers from a lack of clear definition, putting biologists in a paradoxical situation where one can describe at the atomic level complex objects
Externí odkaz:
https://doaj.org/article/ed1b60f5970d4266aac63be01eb91af0
Publikováno v:
Viruses, Vol 15, Iss 9, p 1854 (2023)
The molecular mechanisms controlling the adaptation of viruses to host cells are generally poorly documented. An essential issue to resolve is whether host membranes, and especially lipid rafts, which are usually considered passive gateways for many
Externí odkaz:
https://doaj.org/article/7e76604f78694ce6a4d6dfefa3e634ba
Structure of the Myelin Sheath Proteolipid Plasmolipin (PLLP) in a Ganglioside-Containing Lipid Raft
Autor:
Fodil Azzaz, Morgane Mazzarino, Henri Chahinian, Nouara Yahi, Coralie Di Scala, Jacques Fantini
Publikováno v:
Frontiers in Bioscience-Landmark, Vol 28, Iss 8, p 157 (2023)
Background: Plasmolipin (PLLP) is a membrane protein located in lipid rafts that participates in the formation of myelin. It is also implicated in many pathologies, such as neurological disorders, type 2 diabetes, and cancer metastasis. To better und
Externí odkaz:
https://doaj.org/article/2575f6f4269241cda1ed6cc6850ca566
Publikováno v:
Viruses, Vol 15, Iss 2, p 284 (2023)
Virus-cell interactions involve fundamental parameters that need to be considered in strategies implemented to control viral outbreaks. Among these, the surface electrostatic potential can give valuable information to deal with new epidemics. In this
Externí odkaz:
https://doaj.org/article/973a1adb9eb64de89ea1e0160e2d1c17
Publikováno v:
International Journal of Molecular Sciences, Vol 24, Iss 3, p 1923 (2023)
Although very different, in terms of their genomic organization, their enzymatic proteins, and their structural proteins, HIV and SARS-CoV-2 have an extraordinary evolutionary potential in common. Faced with various selection pressures that may be ge
Externí odkaz:
https://doaj.org/article/5e9f1438cdc040eb8635958c07db3026
Publikováno v:
International Journal of Molecular Sciences, Vol 24, Iss 2, p 1760 (2023)
A broad range of data identify Ca2+-permeable amyloid pores as the most neurotoxic species of Alzheimer’s β-amyloid peptide (Aβ1–42). Following the failures of clinical trials targeting amyloid plaques by immunotherapy, a consensus is gradually
Externí odkaz:
https://doaj.org/article/29df0101c9a7496c96ec9e451e9ef56c
Publikováno v:
Viruses, Vol 14, Iss 11, p 2531 (2022)
The recent outbreak of Monkeypox virus requires the development of a vaccine specifically directed against this virus as quickly as possible. We propose here a new strategy based on a two-step analysis combining (i) the search for binding domains of
Externí odkaz:
https://doaj.org/article/d7f3605959b5416e87782dc66e60c891
Autor:
Coralie Di Scala, Nicholas Armstrong, Henri Chahinian, Eric Chabrière, Jacques Fantini, Nouara Yahi
Publikováno v:
International Journal of Molecular Sciences, Vol 23, Iss 21, p 13383 (2022)
Neurodegenerative disorders are a major public health issue. Despite decades of research efforts, we are still seeking an efficient cure for these pathologies. The initial paradigm of large aggregates of amyloid proteins (amyloid plaques, Lewis bodie
Externí odkaz:
https://doaj.org/article/fd428f9d8f85422ea14e106b834df98e