The impact of Bdnf gene deficiency to the memory impairment and brain pathology of APPswe/PS1dE9 mouse model of Alzheimer's disease.

Autor: Tomi Rantamäki, Susanna Kemppainen, Henri Autio, Saara Stavén, Hennariikka Koivisto, Masami Kojima, Hanna Antila, Pasi O Miettinen, Elisa Kärkkäinen, Nina Karpova, Liisa Vesa, Lothar Lindemann, Marius C Hoener, Heikki Tanila, Eero Castrén

Publikováno v: PLoS ONE, Vol 8, Iss 7, p e68722 (2013)

Brain-derived neurotrophic factor (BDNF) importantly regulates learning and memory and supports the survival of injured neurons. Reduced BDNF levels have been detected in the brains of Alzheimer's disease (AD) patients but the exact role of BDNF in t

Externí odkaz: https://doaj.org/article/c57728a0617c488a94514e4337b67faa

Isoflurane produces antidepressant effects and induces TrkB signaling in rodents

Autor: Ramon Guirado, Sari E. Lauri, Vinicius Sato, Mikhail Kislin, Liisa Vesa, Maria Ryazantseva, Leonard Khiroug, Sâmia R.L. Joca, Jesse Lindholm, Joshua Cordeira, Ipek Yalcin, Eero Castrén, Pia Sipilä, Dina Popova, Plinio C. Casarotto, Tomi Rantamäki, Samuel Kohtala, Henri Autio, Hanna Antila, Maribel Rios, Tomi Taira

Publikováno v: Scientific Reports, Vol 7, Iss 1, Pp 1-12 (2017)
Scientific Reports
Repositório Institucional da USP (Biblioteca Digital da Produção Intelectual)
Universidade de São Paulo (USP)
instacron:USP
Antila, H, Ryazantseva, M, Popova, D, Sipilä, P, Guirado, R, Kohtala, S, Yalcin, I, Lindholm, J, Vesa, L, Sato, V, Cordeira, J, Autio, H, Kislin, M, Rios, M, Joca, S, Casarotto, P, Khiroug, L, Lauri, S, Taira, T, Castrén, E & Rantamäki, T 2017, ' Isoflurane produces antidepressant effects and induces TrkB signaling in rodents ', Scientific Reports, vol. 7, no. 1, pp. 7811 . https://doi.org/10.1038/s41598-017-08166-9

A brief burst-suppressing isoflurane anesthesia has been shown to rapidly alleviate symptoms of depression in a subset of patients, but the neurobiological basis of these observations remains obscure. We show that a single isoflurane anesthesia produ

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c283e5110533f9a62d72bdb5d5779c3f
https://doaj.org/article/9b0a9c01a2904ac9a4a5d9e945138f61

Acetylcholinesterase inhibitors rapidly activate Trk neurotrophin receptors in the mouse hippocampus

Autor: Lothar Lindemann, Eero Castrén, Tomi Rantamäki, Kert Mätlik, Moses V. Chao, Henri Autio, Urmas Arumäe, Marius C. Hoener

Publikováno v: Neuropharmacology. 61:1291-1296

Acetylcholinesterase inhibitors are first-line therapies for Alzheimer’s disease. These drugs increase cholinergic tone in the target areas of the cholinergic neurons of the basal forebrain. Basal forebrain cholinergic neurons are dependent upon tr

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2bed2e33e798b55674ec17e1599a2d4c
https://doi.org/10.1016/j.neuropharm.2011.07.033

Mapping of the Interaction Site between Sortilin and the p75 Neurotrophin Receptor Reveals a Regulatory Role for the Sortilin Intracellular Domain in p75 Neurotrophin Receptor Shedding and Apoptosis

Autor: Henri Autio, Peder Madsen, Simon Glerup, Elizabeth J. Coulson, Dusan Matusica, Eero Castrén, Anders Nykjaer, Alex M. Sykes, Sune Skeldal, Zoran Boskovic, Nickless Palstra

Publikováno v: Skeldal, S, Sykes, A M, Glerup, S, Matusica, D, Palstra, N, Autio, H, Boskovic, Z, Madsen, P, Castrén, E, Nykjaer, A & Coulson, E J 2012, ' Mapping of the Interaction Site between Sortilin and the p75 Neurotrophin Receptor Reveals a Regulatory Role for the Sortilin Intracellular Domain in p75 Neurotrophin Receptor Shedding and Apoptosis ', Journal of Biological Chemistry, vol. 287, no. 52, pp. 43798-809 . https://doi.org/10.1074/jbc.M112.374710

Neurotrophins comprise a group of neuronal growth factors that are essential for the development and maintenance of the nervous system. However, the immature pro-neurotrophins promote apoptosis by engaging in a complex with sortilin and the p75 neuro

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3a05a65529a8a86c954c7c8f93b46169
https://pure.au.dk/portal/da/publications/mapping-of-the-interaction-site-between-sortilin-and-the-p75-neurotrophin-receptor-reveals-a-regulatory-role-for-the-sortilin-intracellular-domain-in-p75-neurotrophin-receptor-shedding-and-apoptosis(e5b557c1-ee9b-4673-a152-80a30d548ed5).html

Impaired TrkB receptor signaling contributes to memory impairment in APP/PS1 mice

Autor: Hugo Vicente Miranda, Maria José Diógenes, Susanna Kemppainen, Tomi Rantamäki, Saara Stavén, Heikki Tanila, Ana M. Sebastião, Eero Castrén, Sabrina Davis, André Jerónimo-Santos, Nina N. Karpova, Serge Laroche, Tiago F. Outeiro, Henri Autio, Gregoire Lavasseur, Elisa Kärkkäinen

Publikováno v: Neurobiology of Aging
Neurobiology of Aging, Elsevier, 2012, 33 (1122e), pp.23-39. ⟨10.1016/j.neurobiolaging.2011.11.006⟩

International audience; Brain-derived neurotrophic factor (BDNF) plays an important role in neuronal plasticity, learning, and memory. Levels of BDNF and its main receptor TrkB (TrkB.TK) have been reported to be decreased while the levels of the trun

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ed9c3a56790adbee443c241b29e47591
https://doi.org/10.1016/j.neurobiolaging.2011.11.006