Zobrazeno 1 - 10
of 51
pro vyhledávání: '"Henriëtte L. Lanz"'
Publikováno v:
STAR Protocols, Vol 5, Iss 1, Pp 102879- (2024)
Summary: Organ-on-a-chip technology incorporating stem cell techniques represents a promising strategy to improve modeling of human organs. Here, we present a protocol for generating a standardized 3D placenta-on-a-chip model using trophoblast derive
Externí odkaz:
https://doaj.org/article/41efff868c7940b9829db80b5b184f4d
Autor:
Agathe Lermant, Gwenaëlle Rabussier, Henriëtte L. Lanz, Lindsay Davidson, Iain M. Porter, Colin E. Murdoch
Publikováno v:
iScience, Vol 26, Iss 7, Pp 107240- (2023)
Summary: Although recently developed placenta-on-chip systems opened promising perspectives for placental barrier modeling, they still lack physiologically relevant trophoblasts and are poorly amenable to high-throughput studies. We aimed to implemen
Externí odkaz:
https://doaj.org/article/a5843bf8b2b74ec793eae1ebf1ab0367
Autor:
Camilla Soragni, Tessa Vergroesen, Nynke Hettema, Gwenaëlle Rabussier, Henriëtte L. Lanz, Sebastian J. Trietsch, Leon J. de Windt, Chee P. Ng
Publikováno v:
STAR Protocols, Vol 4, Iss 1, Pp 102051- (2023)
Summary: Traditionally, to quantify permeability of a biological barrier, the initial slope is used, based on the assumption of sink condition (concentration of the donor is constant, and the receiver increases less than 10%). With on-a-chip barrier
Externí odkaz:
https://doaj.org/article/3273d2ea22874606af3d695eca985936
Autor:
Nienke R. Wevers, Arya Lekshmi Nair, Tania M. Fowke, Maria Pontier, Dhanesh G. Kasi, Xandor M. Spijkers, Charlie Hallard, Gwenaëlle Rabussier, Remko van Vught, Paul Vulto, Helga E. de Vries, Henriëtte L. Lanz
Publikováno v:
Fluids and Barriers of the CNS, Vol 18, Iss 1, Pp 1-18 (2021)
Abstract Background In ischemic stroke, the function of the cerebral vasculature is impaired. This vascular structure is formed by the so-called neurovascular unit (NVU). A better understanding of the mechanisms involved in NVU dysfunction and recove
Externí odkaz:
https://doaj.org/article/b8e062e78c674526a9e9f6fc8baa3af9
Autor:
Camilla Soragni, Gwenaëlle Rabussier, Henriëtte L. Lanz, Kristin M. Bircsak, Leon J. de Windt, Sebastiaan J. Trietsch, Colin E. Murdoch, Chee Ping Ng
Publikováno v:
Redox Biology, Vol 57, Iss , Pp 102488- (2022)
Reactive oxygen species (ROS) have different properties and biological functions. They contribute to cell signaling and, in excessive amounts, to oxidative stress (OS). Although ROS is pivotal in a wide number of physiological systems and pathophysio
Externí odkaz:
https://doaj.org/article/857f974442214bc5869b76984b57a033
Autor:
Sindhu Naik, Andrew R. Wood, Maté Ongenaert, Paniz Saidiyan, Edo D. Elstak, Henriëtte L. Lanz, Jan Stallen, Richard Janssen, Elizabeth Smythe, Kai S. Erdmann
Publikováno v:
International Journal of Molecular Sciences, Vol 22, Iss 10, p 5361 (2021)
Lowe syndrome and Dent II disease are X-linked monogenetic diseases characterised by a renal reabsorption defect in the proximal tubules and caused by mutations in the OCRL gene, which codes for an inositol-5-phosphatase. The life expectancy of patie
Externí odkaz:
https://doaj.org/article/b0fd7188d00e42bd8e7ba7895f271a6b
Autor:
Sebastiaan J. Trietsch, Elena Naumovska, Dorota Kurek, Meily C. Setyawati, Marianne K. Vormann, Karlijn J. Wilschut, Henriëtte L. Lanz, Arnaud Nicolas, Chee Ping Ng, Jos Joore, Stefan Kustermann, Adrian Roth, Thomas Hankemeier, Annie Moisan, Paul Vulto
Publikováno v:
Nature Communications, Vol 8, Iss 1, Pp 1-8 (2017)
Efforts to determine the effects of drugs on epithelial barriers could benefit from better in vitro models. Here the authors develop a microfluidic device supporting the growth and function of extracellular matrix-supported intestinal tubules, and ev
Externí odkaz:
https://doaj.org/article/936a946cd151424cbb470b23c064cef4
Autor:
Bart Kramer, Luuk de Haan, Marjolein Vermeer, Thomas Olivier, Thomas Hankemeier, Paul Vulto, Jos Joore, Henriëtte L. Lanz
Publikováno v:
International Journal of Molecular Sciences, Vol 20, Iss 18, p 4647 (2019)
Pancreatic Ductal Adenocarcinoma (PDAC) is one of the most lethal cancers due to a high chemoresistance and poor vascularization, which results in an ineffective systemic therapy. PDAC is characterized by a high intratumoral pressure, which is not ca
Externí odkaz:
https://doaj.org/article/d79910a9b0ca4e769269a7f4bfdf574d
Autor:
Gwenaëlle Rabussier, Ivan Bünter, Josse Bouwhuis, Camilla Soragni, Torben van Zijp, Chee Ping Ng, Karel Domansky, Leon J. de Windt, Paul Vulto, Colin E. Murdoch, Kristin M. Bircsak, Henriëtte L. Lanz
Publikováno v:
Acta Biomaterialia. 164:363-376
Autor:
Arnaud Nicolas, Carola M. E. Ammerlaan, Linda Gijzen, Marianne K. Vormann, Paul Vulto, Maarten B. Rookmaaker, Frans Schutgens, Dorota Kurek, Hans Clevers, Fjodor A. Yousef Yengej, Henriëtte L. Lanz, Marianne C. Verhaar
Publikováno v:
Nature Protocols, 16(4), 2023-2050. Nature Publishing Group
Advanced in vitro kidney models are of great importance to the study of renal physiology and disease. Kidney tubuloids can be established from primary cells derived from adult kidney tissue or urine. Tubuloids are three-dimensional multicellular stru