Zobrazeno 1 - 10
of 84
pro vyhledávání: '"Henri, Xhaard"'
Autor:
Maiju K. Rinne, Lauri Urvas, Ilona Mandrika, Dāvids Fridmanis, Darren M. Riddy, Christopher J. Langmead, Jyrki P. Kukkonen, Henri Xhaard
Publikováno v:
Scientific Reports, Vol 14, Iss 1, Pp 1-15 (2024)
Abstract Tunicates are evolutionary model organisms bridging the gap between vertebrates and invertebrates. A genomic sequence in Ciona intestinalis (CiOX) shows high similarity to vertebrate orexin receptors and protostome allatotropin receptors (AT
Externí odkaz:
https://doaj.org/article/3532f53292dc43e187ca5d3298309620
Autor:
Riccardo Provenzani, Paola San-Martin-Galindo, Ghada Hassan, Ashenafi Legehar, Aleksi Kallio, Henri Xhaard, Adyary Fallarero, Jari Yli-Kauhaluoma
Publikováno v:
Scientific Reports, Vol 11, Iss 1, Pp 1-10 (2021)
Abstract Biofilms are multicellular communities of microorganisms that generally attach to surfaces in a self-produced matrix. Unlike planktonic cells, biofilms can withstand conventional antibiotics, causing significant challenges in the healthcare
Externí odkaz:
https://doaj.org/article/31c6533710d348fb836b7b06e81689d3
Autor:
Saara Lautala, Riccardo Provenzani, Ilari Tarvainen, Katia Sirna, S. Tuuli Karhu, Evgeni Grazhdankin, Antti K. Lehtinen, Hanan Sa’d, Artturi Koivuniemi, Henri Xhaard, Raimo K. Tuominen, Virpi Talman, Alex Bunker, Jari Yli-Kauhaluoma
Publikováno v:
Journal of Medicinal Chemistry. 66:4588-4602
Autor:
Jaakko Itkonen, Leo Ghemtio, Daniela Pellegrino, Pia J. Jokela (née Heinonen), Henri Xhaard, Marco G. Casteleijn
Publikováno v:
Pharmaceutics, Vol 14, Iss 8, p 1639 (2022)
Pharmaceutical proteins, compared to small molecular weight drugs, are relatively fragile molecules, thus necessitating monitoring protein unfolding and aggregation during production and post-marketing. Currently, many analytical techniques take offl
Externí odkaz:
https://doaj.org/article/927cd2094a154036a17e0b177537a3c5
Autor:
Teppo O. Leino, Ainoleena Turku, Lauri Urvas, Karuna Adhikari, Jouni Oksanen, Yana Steynen, Jari Yli-Kauhaluoma, Henri Xhaard, Jyrki P. Kukkonen, Erik A.A. Wallén
Azulene is a rare ring structure in drugs, and we investigated whether it could be used as a biphenyl mimetic in known orexin receptor agonist Nag 26, which is binding to both orexin receptors OX1 and OX2 with preference towards OX2. The most potent
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d7df09711b7611d8344b9ac76de0bc4c
http://hdl.handle.net/10138/359559
http://hdl.handle.net/10138/359559
Publikováno v:
Journal of Cheminformatics, Vol 10, Iss 1, Pp 1-16 (2018)
Abstract Betulin derivatives have been proven effective in vitro against Leishmania donovani amastigotes, which cause visceral leishmaniasis. Identifying the molecular targets and molecular mechanisms underlying their action is a currently an unmet c
Externí odkaz:
https://doaj.org/article/21c7480e649348d38af3c4d5992e678f
Publikováno v:
ACS Omega, Vol 2, Iss 10, Pp 7359-7374 (2017)
Externí odkaz:
https://doaj.org/article/aaffd7c449d74ddaa17b59908c42a3f1
Autor:
Alisa Pavel, Giusy del Giudice, Michele Fratello, Leo Ghemtio, Antonio Di Lieto, Jari Yli-Kauhaluoma, Henri Xhaard, Antonio Federico, Angela Serra, Dario Greco
Publikováno v:
Bioinformatics.
Motivation Transcriptomic data can be used to describe the mechanism of action (MOA) of a chemical compound. However, omics data tend to be complex and prone to noise, making the comparison of different datasets challenging. Often, transcriptomic pro
Autor:
Jianing Liu, Loic Dreano, Keni Vidilaseris, Gustav Boije af Gennäs, Jari Yli-Kauhaluoma, Arthur Lasbleiz, Henri Xhaard, Niklas G. Johansson, Alexandros Kiriazis, Orquidea Marilia de Castro Ribeiro, Adrian Goldman, Ayman Khattab, Seppo Meri
Publikováno v:
Chemmedchem
Inhibition of membrane‐bound pyrophosphatase (mPPase) with small molecules offer a new approach in the fight against pathogenic protozoan parasites. mPPases are absent in humans, but essential for many protists as they couple pyrophosphate hydrolys
Publikováno v:
Molecular Informatics. 42