Zobrazeno 1 - 10
of 62
pro vyhledávání: '"Henning Thøgersen"'
Autor:
Kirsten Raun, Sara G. Vienberg, Birgitte Andersen, Tina Møller Tagmose, Xin Zhao, Xujia Zhang, Henning Thøgersen, Kristian Sass-Ørum, Ann Maria Kruse Hansen, Dan Han, Kirsten Lykkegaard, Goa Tingqing
Publikováno v:
Biochemical Journal. 475:2985-2996
Fibroblast growth factors (FGF) 19, 21 and 23 are characterized by being endocrinely secreted and require co-receptor α-klotho or β-klotho (BKL) for binding and activation of the FGF receptors (FGFR). FGF15 is the rodent orthologue of human FGF19,
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a5e7aa51ad1b5bc4f782e5fe16ff20b4
https://doi.org/10.1042/bcj20180555
https://doi.org/10.1042/bcj20180555
A protocol was defined which utilised peptides as probes for the characterisation of reversed phase chromatography peptide separation systems. These peptide probes successfully distinguished between differing stationary phases through the probe's hyd
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9966eac4d1426623b6e678933eca0a6b
https://strathprints.strath.ac.uk/69134/1/Field_etal_JCA_2019_Investigation_into_reversed_phase_chromatography_peptide_separation_systems_part_I.pdf
https://strathprints.strath.ac.uk/69134/1/Field_etal_JCA_2019_Investigation_into_reversed_phase_chromatography_peptide_separation_systems_part_I.pdf
Publikováno v:
Protein expression and purification. 170
N-terminal extensions ("tags") have proven valuable for producing peptides using high throughput recombinant expression technologies. However, the applicability is hampered by the limited options for specific and efficient proteases to release the fu
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::023ddabb40b6ecd758b2e2ecc633ece1
https://pubmed.ncbi.nlm.nih.gov/32007557
https://pubmed.ncbi.nlm.nih.gov/32007557
Autor:
Leonardo De Maria, Stephanie Hennen, Lars Linderoth, Alberto Oddo, Jacob Kofoed, Henning Thøgersen, James N. McGuire, Sofia Mortensen, Steffen Reedtz-Runge
Publikováno v:
Biochemistry. 57(28)
Peptide agonists acting on the glucagon-like peptide 1 receptor (GLP-1R) promote glucose-dependent insulin release and therefore represent important therapeutic agents for type 2 diabetes (T2D). Previous data indicated that an N-terminal type II β-t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::37a2c2a8509432bcc0645673e757005b
https://pubmed.ncbi.nlm.nih.gov/29877701
https://pubmed.ncbi.nlm.nih.gov/29877701
Autor:
Henning Thøgersen, Leif Christensen, Helle Birk Olsen, Cecilia Nilsson, Ulrich Sensfuss, Thomas Kruse Hansen, Kilian Conde-Frieboes, Kirsten Raun, Kirsten Dahl, Birgit Sehested Hansen, Jane Spetzler, Birgitte Schjellerup Wulff, Jesper Lau
Publikováno v:
Journal of Medicinal Chemistry. 55:1969-1977
We report in vitro and in vivo data of new α-melanocyte-stimulating hormone (α-MSH) analogues which are N-terminal modified with a long chain fatty acid derivative. While keeping the pharmacophoric motif (d-Phe-Arg-Trp) fixed, we tried to improve s
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::506c57b49d0e739285b222ba20d7d798
https://doi.org/10.1021/jm201489a
https://doi.org/10.1021/jm201489a
Autor:
Kirsten Raun, Birgit Sehested Hansen, Henning Thøgersen, Michael Ankersen, Kilian Conde-Frieboes, Birgitte Schjellerup Wulff, Jens Breinholt
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 21:1459-1463
A new class of melanocortin 4 receptor (MC4r) agonists was discovered from an unexpected sidereaction in which formaldehyde caused cyclization. These cyclophanes were found to be sub micromolar agonists of the MC1 and MC4 and were less potent on the
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2dfcb4e219be3a3cbf37118ab9dedd4f
https://doi.org/10.1016/j.bmcl.2011.01.011
https://doi.org/10.1016/j.bmcl.2011.01.011
Autor:
Per Franklin Nielsen, N. L. Johansen, Kjeld Madsen, Lotte Bjerre Knudsen, Henrik Agersoe, Henning Thøgersen, Michael Wilken
Publikováno v:
Journal of Medicinal Chemistry. 50:6126-6132
We here report a series of derivatives describing the structure-activity relationship around liraglutide, a once-daily human glucagon-like peptide-1 fatty acid derivative, with respect to potency as well as protraction in vivo. The spacer region betw
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4d56f5c7bd00b8530ddcbf29aae58002
https://doi.org/10.1021/jm070861j
https://doi.org/10.1021/jm070861j
Autor:
Susann Schimmer, Henning Thøgersen, Steffen Runge, Sanne Möller Knudsen, Jesper Lau, Rainer Rudolph, Kjeld Madsen, Jan Oschmann, Claus Bekker Jeppesen, Christine Bruun Schiødt
Publikováno v:
Biochemistry. 46:5830-5840
Glucagon-like peptide-1 (GLP-1) and exendin-4 (Ex4) are homologous peptides with established potential for treatment of type 2 diabetes. They bind and activate the pancreatic GLP-1 receptor (GLP-1R) with similar affinity and potency and thereby promo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2178a15d6eab146d6bd8b086f4dfbba9
https://doi.org/10.1021/bi062309m
https://doi.org/10.1021/bi062309m
Autor:
Kent Bondensgaard, Henning Thøgersen, Birgitte Schjellerup Wulff, Robert P. Bywater, Birgit Sehested Hansen, Michael Ankersen
Publikováno v:
Journal of Medicinal Chemistry. 47:888-899
Privileged structures are ligand substructures that are widely used to generate high-affinity ligands for more than one type of receptor. To explain this, we surmised that there must be some common feature in the target proteins. For a set of class A
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9080a39b78a525510867fae72ff47fc2
https://doi.org/10.1021/jm0309452
https://doi.org/10.1021/jm0309452
Publikováno v:
The Journal of Organic Chemistry. 67:1227-1232
A new versatile synthetic route is presented for the cyclization of tripeptides on solid support using nucleophilic aromatic substitution in the cyclization step. Identification of all conformers within a limit of 3 kcal/mol from the identified globa
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9c7da5d59aefa5372a1d9e069f86b3ed
https://doi.org/10.1021/jo016269y
https://doi.org/10.1021/jo016269y