Zobrazeno 1 - 10
of 53
pro vyhledávání: '"Henning Kempf"'
Autor:
Sean P. Harrison, Richard Siller, Yoshiaki Tanaka, Maria Eugenia Chollet, María Eugenia de la Morena-Barrio, Yangfei Xiang, Benjamin Patterson, Elisabeth Andersen, Carlos Bravo-Pérez, Henning Kempf, Kathrine S. Åsrud, Oleg Lunov, Alexandr Dejneka, Marie-Christine Mowinckel, Benedicte Stavik, Per Morten Sandset, Espen Melum, Saphira Baumgarten, Flavio Bonanini, Dorota Kurek, Santosh Mathapati, Runar Almaas, Kulbhushan Sharma, Steven R. Wilson, Frøydis S. Skottvoll, Ida C. Boger, Inger Lise Bogen, Tuula A. Nyman, Jun Jie Wu, Ales Bezrouk, Dana Cizkova, Javier Corral, Jaroslav Mokry, Robert Zweigerdt, In-Hyun Park, Gareth J. Sullivan
Publikováno v:
Experimental and Molecular Medicine, Vol 55, Iss 9, Pp 2005-2024 (2023)
Abstract The lack of physiological parity between 2D cell culture and in vivo culture has led to the development of more organotypic models, such as organoids. Organoid models have been developed for a number of tissues, including the liver. Current
Externí odkaz:
https://doaj.org/article/807e8461f64a4203a1ae380b8b984277
Autor:
Benedikt Jaeger, Jonas Christian Schupp, Linda Plappert, Oliver Terwolbeck, Nataliia Artysh, Gian Kayser, Peggy Engelhard, Taylor Sterling Adams, Robert Zweigerdt, Henning Kempf, Stefan Lienenklaus, Wiebke Garrels, Irina Nazarenko, Danny Jonigk, Malgorzata Wygrecka, Denise Klatt, Axel Schambach, Naftali Kaminski, Antje Prasse
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-17 (2022)
The functional role of airway basal cells has not been comprehensively studied in idiopathic pulmonary fibrosis (IPF). Here, the authors show that airway basal cells of IPF patients display a distinct phenotype, are profibrotic if transplanted to mic
Externí odkaz:
https://doaj.org/article/107b6a818628494fa216ab22d702c61d
Autor:
Caroline Halloin, Kristin Schwanke, Wiebke Löbel, Annika Franke, Monika Szepes, Santoshi Biswanath, Stephanie Wunderlich, Sylvia Merkert, Natalie Weber, Felix Osten, Jeanne de la Roche, Felix Polten, Kai Wollert, Theresia Kraft, Martin Fischer, Ulrich Martin, Ina Gruh, Henning Kempf, Robert Zweigerdt
Publikováno v:
Stem Cell Reports, Vol 13, Iss 2, Pp 366-379 (2019)
Summary: Aiming at clinical translation, robust directed differentiation of human pluripotent stem cells (hPSCs), preferentially in chemically defined conditions, is a key requirement. Here, feasibility of suspension culture based hPSC-cardiomyocyte
Externí odkaz:
https://doaj.org/article/5bf4901f96304fee8eb8aff796b40560
Autor:
Mania Ackermann, Henning Kempf, Miriam Hetzel, Christina Hesse, Anna Rafiei Hashtchin, Kerstin Brinkert, Juliane Wilhelmine Schott, Kathrin Haake, Mark Philipp Kühnel, Silke Glage, Constanca Figueiredo, Danny Jonigk, Katherina Sewald, Axel Schambach, Sabine Wronski, Thomas Moritz, Ulrich Martin, Robert Zweigerdt, Antje Munder, Nico Lachmann
Publikováno v:
Nature Communications, Vol 9, Iss 1, Pp 1-13 (2018)
Pulmonary infections constitute a substantial health problem worldwide. Here the authors show that phagocytes similar to primitive macrophages can be generated from human induced pluripotent stem cells, by the use of industry-compatible, stirred-tank
Externí odkaz:
https://doaj.org/article/14b2e8c926bf42f1a34ca9cec6a3b9d0
Autor:
Mania Ackermann, Kathrin Haake, Henning Kempf, Paul Kaschutnig, Anna-Carina Weiss, Ariane H.H. Nguyen, Markus Abeln, Sylvia Merkert, Mark Phillip Kühnel, Dorothee Hartmann, Danny Jonigk, Thomas Thum, Andreas Kispert, Michael D. Milsom, Nico Lachmann
Publikováno v:
Haematologica, Vol 106, Iss 5 (2020)
Hematopoietic development is spatiotemporally tightly regulated by defined cell-intrinsic and extrinsic modifiers. The role of cytokines has been intensively studied in adult hematopoiesis; however, their role in embryonic hematopoietic specification
Externí odkaz:
https://doaj.org/article/a74ac7cd574543a09df90921c75da6e4
Autor:
Erika Gaspari, Annika Franke, Diana Robles-Diaz, Robert Zweigerdt, Ingo Roeder, Thomas Zerjatke, Henning Kempf
Publikováno v:
Stem Cell Research, Vol 32, Iss , Pp 1-7 (2018)
With their capability to self-renew and differentiate into derivatives of all three germ layers, human pluripotent stem cells (hPSCs) offer a unique model to study aspects of human development in vitro. Directed differentiation towards mesendodermal
Externí odkaz:
https://doaj.org/article/12a120551cce441da3e8611767bc736c
Autor:
Adele Mucci, Elena Lopez-Rodriguez, Miriam Hetzel, Serena Liu, Takuji Suzuki, Christine Happle, Mania Ackermann, Henning Kempf, Roman Hillje, Jessica Kunkiel, Ewa Janosz, Sebastian Brennig, Silke Glage, Jens P. Bankstahl, Sabine Dettmer, Thomas Rodt, Gudrun Gohring, Bruce Trapnell, Gesine Hansen, Cole Trapnell, Lars Knudsen, Nico Lachmann, Thomas Moritz
Publikováno v:
Stem Cell Reports, Vol 11, Iss 3, Pp 696-710 (2018)
Summary: Induced pluripotent stem cell (iPSC)-derived hematopoietic cells represent a highly attractive source for cell and gene therapy. Given the longevity, plasticity, and self-renewal potential of distinct macrophage subpopulations, iPSC-derived
Externí odkaz:
https://doaj.org/article/0db0413ad9c9422987973761b3e060bd
Autor:
Ruth Olmer, Lena Engels, Abdulai Usman, Sandra Menke, Muhammad Nasir Hayat Malik, Frank Pessler, Gudrun Göhring, Dorothee Bornhorst, Svenja Bolten, Salim Abdelilah-Seyfried, Thomas Scheper, Henning Kempf, Robert Zweigerdt, Ulrich Martin
Publikováno v:
Stem Cell Reports, Vol 10, Iss 5, Pp 1657-1672 (2018)
Summary: Endothelial cells (ECs) are involved in a variety of cellular responses. As multifunctional components of vascular structures, endothelial (progenitor) cells have been utilized in cellular therapies and are required as an important cellular
Externí odkaz:
https://doaj.org/article/c660b60a1dbb42bda49bd7428389c182
Autor:
Christoph Lipps, Franziska Klein, Tom Wahlicht, Virginia Seiffert, Milada Butueva, Jeannette Zauers, Theresa Truschel, Martin Luckner, Mario Köster, Roderick MacLeod, Jörn Pezoldt, Jochen Hühn, Qinggong Yuan, Peter Paul Müller, Henning Kempf, Robert Zweigerdt, Oliver Dittrich-Breiholz, Thomas Pufe, Rainer Beckmann, Wolf Drescher, Jose Riancho, Carolina Sañudo, Thomas Korff, Bertram Opalka, Vera Rebmann, Joachim R. Göthert, Paula M. Alves, Michael Ott, Roland Schucht, Hansjörg Hauser, Dagmar Wirth, Tobias May
Publikováno v:
Nature Communications, Vol 9, Iss 1, Pp 1-12 (2018)
Personalised medicine requires cell cultures from defined genetic backgrounds, but providing sufficient numbers of cells is a challenge. Here the authors develop gene cocktails to expand primary cells from a variety of different tissues and species,
Externí odkaz:
https://doaj.org/article/e9ef9c4a20664d78b68d4039733b3449
Autor:
Diana Massai, Emiliano Bolesani, Diana Robles Diaz, Christina Kropp, Henning Kempf, Caroline Halloin, Ulrich Martin, Tudor Braniste, Giuseppe Isu, Vanessa Harms, Umberto Morbiducci, Gerald Dräger, Robert Zweigerdt
Publikováno v:
Scientific Reports, Vol 7, Iss 1, Pp 1-15 (2017)
Abstract Controlled large-scale production of human pluripotent stem cells (hPSCs) is indispensable for their envisioned clinical translation. Aiming at advanced process development in suspension culture, the sensitivity of hPSC media to continuous p
Externí odkaz:
https://doaj.org/article/5744c11d0e5c48dbaab771a3b762e064