Zobrazeno 1 - 10
of 15
pro vyhledávání: '"Henning J. Draheim"'
Autor:
Yousra El Ghaleb, Nadine J. Ortner, Wilfried Posch, Monica L. Fernández-Quintero, Wietske E. Tuinte, Stefania Monteleone, Henning J. Draheim, Klaus R. Liedl, Doris Wilflingseder, Jörg Striessnig, Petronel Tuluc, Bernhard E. Flucher, Marta Campiglio
Publikováno v:
Journal of General Physiology. 154
The skeletal muscle voltage-gated calcium channel (CaV1.1) primarily functions as a voltage sensor for excitation–contraction coupling. Conversely, its ion-conducting function is modulated by multiple mechanisms within the pore-forming α1S subunit
Autor:
Maria Kharitonova, Simon Hess, Birgit Liss, Petronel Tuluc, Nadia Stefanova, Thomas Pomberger, Antonios Dougalis, Peter Kloppenburg, Nadine J. Ortner, Florian Pitterl, Herbert Oberacher, Joerg Striessnig, Gabriella Bock, Thomas Ciossek, Henning J. Draheim, Johanna Duda
Publikováno v:
The Journal of Neuroscience. 37:6761-6777
Ca(2+)-influx through L-type Ca(2+)-channels (LTCCs) is associated with activity-related stressful oscillations of Ca(2+) levels within dopaminergic (DA) neurons in the substantia nigra (SN), which may contribute to their selective degeneration in Pa
Publikováno v:
Neuroscience. 208:41-48
Mutations in leucine-rich repeat kinase 2 (LRRK2) have been causally linked to neuronal cell death in Parkinson's disease. LRRK2 expression has also been detected in B lymphocytes and macrophages, suggesting a role in immune responses. In the present
Autor:
Simon Moussaud, Henning J. Draheim
Publikováno v:
Journal of Neuroscience Methods. 187:243-253
As the major immuno-competent cells of the brain, microglia are highly implicated in neuro-protection as well as in neurodegeneration. Therefore, they are of key interest for research on numerous CNS diseases. Currently, to model inflammation in the
Publikováno v:
Cellular Physiology and Biochemistry. 24:141-152
Microglia are the intrinsic immune cells of the brain. As such, they are crucially involved in neuro-protection as well as neuro-degeneration. Their activation leads to the induction of cytokine and chemokine release, the production of reactive oxyge
Autor:
Heike Franke, Joana Schweigel, Kerstin Wirkner, Clemens Allgaier, Peter Illes, Edward Leon Barsoumian, Zoltan Gerevich, Henning J. Draheim
Publikováno v:
British Journal of Pharmacology. 141:141-151
1. N-type Ca(2+) channel modulation by an endogenous P2Y receptor was investigated by the whole-cell patch-clamp method in HEK 293 cells transfected with the functional rabbit N-type calcium channel. 2. The current responses (I(Ca(N))) to depolarizin
Publikováno v:
Biophysical Journal. 112:240a
Voltage-gated sodium channels (Nav) are crucial to the initiation and propagation of action potentials in electrically excitable cells. Inhibitors of such ion channels have been developed and approved as drugs to treat a variety of indications. In co
Publikováno v:
Cellular Physiology and Biochemistry. 5:145-154
Serum-deprived chicken embryo fibroblasts (CEFs) were stimulated by newborn calf serum (NCS), epidermal growth factor (EGF), platelet-derived growth factor AB chain heterodimer (PDGF-AB), insulin, or
Publikováno v:
Pfl�gers Archiv European Journal of Physiology. 427:17-23
Ion channels in normal and Rous sarcoma virus (RSV)-transformed chicken embryo fibroblasts (CEFs) were examined by using the patch-clamp technique. Three different types of ion channels were observed with single-channel conductances in symmetrical 14
Autor:
Henning J. Draheim, Helmut Kettenmann, Oliver Kann, Uwe-Karsten Hanisch, Ralf R. Schumann, Marco Prinz, Joerg R. Weber
Publikováno v:
Journal of neuropathology and experimental neurology. 58(10)
Gram-positive Streptococcus pneumoniae is the major pathogen causing lethal meningitis in adults. We used pneumococcal cell walls (PCW) to investigate microglial consequences of a bacterial challenge and to determine the role of serum in the activati