Zobrazeno 1 - 7
of 7
pro vyhledávání: '"Henning Hruby"'
Autor:
Sara Pagans, Angelika Pedal, Brian J North, Katrin Kaehlcke, Brett L Marshall, Alexander Dorr, Claudia Hetzer-Egger, Peter Henklein, Roy Frye, Michael W McBurney, Henning Hruby, Manfred Jung, Eric Verdin, Melanie Ott
Publikováno v:
PLoS Biology, Vol 3, Iss 2, p e41 (2005)
The human immunodeficiency virus (HIV) Tat protein is acetylated by the transcriptional coactivator p300, a necessary step in Tat-mediated transactivation. We report here that Tat is deacetylated by human sirtuin 1 (SIRT1), a nicotinamide adenine din
Externí odkaz:
https://doaj.org/article/1f4e87794ef5457ca7e901e53e2cc8de
Autor:
Henning Hruby, Robert C. Neugebauer, Manfred Jung, Urszula Uchiechowska, Wolfgang Sippl, Eric Verdin, Vassil Valkov, Rene Meier
Publikováno v:
Journal of Medicinal Chemistry. 51:1203-1213
NAD (+)-dependent histone deacetylases (sirtuins) are enzymes that cleave acetyl groups from lysines in histones and other proteins. Potent selective sirtuin inhibitors are interesting tools for the investigation of the biological functions of those
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cc516dfa1fe03b77690cffc62ba2872a
https://doi.org/10.1021/jm700972e
https://doi.org/10.1021/jm700972e
Autor:
Antonio Bedalov, Henning Hruby, Manfred Jung, Maki Hirao, Jeffrey Posakony, Melisa Nelson, Julian A. Simon
Publikováno v:
Journal of Biological Chemistry. 278:52773-52782
Sir2 and Hst1 are NAD+-dependent deacetylases involved in transcriptional repression in yeast. The two enzymes are highly homologous yet have different sensitivity to the small-molecule inhibitor splitomicin (compound 1) (Bedalov, A., Gatbonton, T.,
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::197d772c38cbed3441e58ae9912c558a
https://doi.org/10.1074/jbc.m308966200
https://doi.org/10.1074/jbc.m308966200
Autor:
Brian J. North, Michael W. McBurney, Roy A. Frye, Angelika Pedal, Peter Henklein, Katrin Kaehlcke, Sara Pagans, Henning Hruby, Alexander Dorr, Claudia Hetzer-Egger, Brett Marshall, Melanie Ott, Eric Verdin, Manfred Jung
Publikováno v:
PLoS Biology, Vol 3, Iss 2, p e41 (2005)
Scopus-Elsevier
Scopus-Elsevier
The human immunodeficiency virus (HIV) Tat protein is acetylated by the transcriptional coactivator p300, a necessary step in Tat-mediated transactivation. We report here that Tat is deacetylated by human sirtuin 1 (SIRT1), a nicotinamide adenine din
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7b905ecc4bfc5d46b801b6c95e69643b
http://europepmc.org/articles/PMC546329?pdf=render
http://europepmc.org/articles/PMC546329?pdf=render
Autor:
Sara, Pagans, Angelika, Pedal, Brian J, North, Katrin, Kaehlcke, Brett L, Marshall, Alexander, Dorr, Claudia, Hetzer-Egger, Peter, Henklein, Roy, Frye, Michael W, McBurney, Henning, Hruby, Manfred, Jung, Eric, Verdin, Melanie, Ott
Publikováno v:
PLoS Biology
The human immunodeficiency virus (HIV) Tat protein is acetylated by the transcriptional coactivator p300, a necessary step in Tat-mediated transactivation. We report here that Tat is deacetylated by human sirtuin 1 (SIRT1), a nicotinamide adenine din
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::941058bf84695634a64bbb14e77dfc93
https://pubmed.ncbi.nlm.nih.gov/15719057
https://pubmed.ncbi.nlm.nih.gov/15719057
Autor:
Robert C. Neugebauer, Urszula Uchiechowska, Rene Meier, Henning Hruby, Vassil Valkov, Eric Verdin, Wolfgang Sippl, Manfred Jung
Publikováno v:
Journal of Medicinal Chemistry; Feb2008, Vol. 51 Issue 5, p1203-1213, 11p
Autor:
Pagans, Sara1 (AUTHOR), Pedal, Angelika1 (AUTHOR), North, Brian J1 (AUTHOR), Kaehlcke, Katrin1 (AUTHOR), Marshall, Brett L1 (AUTHOR), Dorr, Alexander2 (AUTHOR), Hetzer-Egger, Claudia2 (AUTHOR), Henklein, Peter3 (AUTHOR), Frye, Roy4 (AUTHOR), McBurney, Michael W5 (AUTHOR), Hruby, Henning6 (AUTHOR), Jung, Manfred6 (AUTHOR), Verdin, Eric1 (AUTHOR), Ott, Melanie1,2 (AUTHOR) mott@gladstone.ucsf.edu
Publikováno v:
PLoS Biology. 2/8/2005, Vol. 3 Issue 2, p1-11. 11p.