Common variants in the HLA-DQ region confer susceptibility to idiopathic achalasia

Autor: Luigi Laghi, Jens U. Marquardt, Lude Franke, Harm-Jan Westra, Ralf Kiesslich, Cisca Wijmenga, Julio Perez de la Serna, Rosario Cuomo, Jan Tack, Peter R. Galle, Ines Gockel, Henning G. Schulz, Giovanni Sarnelli, Daniel Drescher, Jessica Becker, Stefan Niebisch, Elisabeth Mangold, Anna Latiano, Paul I.W. de Bakker, V. Annese, Uberto Fumagalli, Antonio Ruiz de León, Michael T. Heneka, Alexander J. Eckardt, Per Hoffmann, Mira M. Wouters, Hans Dieter Allescher, Julian Zimmermann, Timo Hess, Werner Kneist, Elena Urcelay, Ana G. Vigo, Hauke Lang, Markus M. Nöthen, Gosia Trynka, Henning R. Gockel, Burkhard H.A. von Rahden, Vinod Kumar, Karl-Peter Hopfner, David Ramonet, Stefan Herms, Stefanie Heilmann, Michael Knapp, Michaela Müller, Guy E. Boeckxstaens, Johannes Schumacher, Manuel Mattheisen

Publikováno v: BASE-Bielefeld Academic Search Engine
Nature Genetics, 46(8), 901-904. Nature Publishing Group
Gockel, I, Becker, J, Wouters, M M, Niebisch, S, Gockel, H R, Hess, T, Ramonet, D, Zimmermann, J, Vigo, A G, Trynka, G, de León, A R, de la Serna, J P, Urcelay, E, Kumar, V, Franke, L, Westra, H-J, Drescher, D, Kneist, W, Marquardt, J U, Galle, P R, Mattheisen, M, Annese, V, Latiano, A, Fumagalli, U, Laghi, L, Cuomo, R, Sarnelli, G, Müller, M, Eckardt, A J, Tack, J, Hoffmann, P, Herms, S, Mangold, E, Heilmann, S, Kiesslich, R, von Rahden, B H A, Allescher, H-D, Schulz, H G, Wijmenga, C, Heneka, M T, Lang, H, Hopfner, K-P, Nöthen, M M, Boeckxstaens, G E, de Bakker, P I W, Knapp, M & Schumacher, J 2014, ' Common variants in the HLA-DQ region confer susceptibility to idiopathic achalasia ', Nature Genetics . https://doi.org/10.1038/ng.3029

Idiopathic achalasia is characterized by a failure of the lower esophageal sphincter to relax due to a loss of neurons in the myenteric plexus(1,2). This ultimately leads to massive dilatation and an irreversibly impaired megaesophagus. We performed

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d5b02350b253ac6a701faf5c4abdda99
https://doi.org/10.1038/ng.3029

Operative Therapie der gastroösophagealen Refluxkrankheit

Autor: Henning G. Schulz, Rudolph Pointner

Die gastroösophageale Refluxkrankheit ist aufgrund ihrer Häufigkeit und ihres breiten Spektrums möglicher Symptome eine wichtige Diagnose und Differentialdiagnose in der täglichen hausärztlichen und klinischen Praxis und verläuft bei der Mehrza

Genome-wide analysis implicates microRNAs and their target genes in the development of bipolar disorder

Autor: Susanne Lucae, Gerhard Schratt, M.P. Schwarz, Adam Wright, Martin Hautzinger, Philip B. Mitchell, Sharof Khudayberdiev, Nicholas G. Martin, W. Maier, Johannes Schumacher, Piotr M. Czerski, Markus M. Nöthen, Janice M. Fullerton, Susanne Meier, Cristiana Cruceanu, Tim Becker, Jana Strohmaier, Peter R. Schofield, Stefan Herms, Guy A. Rouleau, André Lacour, Thomas G. Schulze, Sugirthan Sivalingam, Galina Pantelejeva, Gustavo Turecki, Elza Khusnutdinova, Lilia I. Abramova, Catherine Laprise, Fermín Mayoral, Stephanie H. Witt, Jens Treutlein, Joanna Hauser, James D. McKay, Sven Cichon, Martin Alda, Bertram Müller-Myhsok, Andreas Reif, Michael Bauer, Manuel Mattheisen, Franziska Degenhardt, Marcella Rietschel, Helmut Vedder, Peter Propping, Alexey Polonikov, Neonilia Szeszenia-Dabrowska, S. E. Medland, Scott D. Gordon, Markus Leber, Valery Krasnov, Lutz Priebe, Alexander Chuchalin, Susanne Moebus, Peter Hoffmann, Gulia Babadjanova, A Verhaert, Thomas W. Mühleisen, M Grigoroiu-Serbanescu, Jolanta Lissowska, Alexander S. Tiganov, Simon Sumer, Henning G. Schulz, Andreas Hofmann, Grant W. Montgomery, Paul Brennan, Anna Maaser, Andreas J. Forstner, Fabio Rivas, Manolis Kogevinas, Andrea Pfennig, Jutta Kammerer-Ciernioch, René Breuer

Publikováno v: Forstner, A J, Hofmann, A, Maaser, A, Sumer, S, Khudayberdiev, S, Mühleisen, T W, Leber, M, Schulze, T G, Strohmaier, J, Degenhardt, F, Treutlein, J, Mattheisen, M, Schumacher, J, Breuer, R, Meier, S, Herms, S, Hoffmann, P, Lacour, A, Witt, S H, Reif, A, Müller-Myhsok, B, Lucae, S, Maier, W, Schwarz, M, Vedder, H, Kammerer-Ciernioch, J, Pfennig, A, Bauer, M, Hautzinger, M, Moebus, S, Priebe, L, Sivalingam, S, Verhaert, A, Schulz, H, Czerski, P M, Hauser, J, Lissowska, J, Szeszenia-Dabrowska, N, Brennan, P, McKay, J D, Wright, A, Mitchell, P B, Fullerton, J M, Schofield, P R, Montgomery, G W, Medland, S E, Gordon, S D, Martin, N G, Krasnov, V, Chuchalin, A, Babadjanova, G, Pantelejeva, G, Abramova, L I, Tiganov, A S, Polonikov, A, Khusnutdinova, E, Alda, M, Cruceanu, C, Rouleau, G A, Turecki, G, Laprise, C, Rivas, F, Mayoral, F, Kogevinas, M, Grigoroiu-Serbanescu, M, Propping, P, Becker, T, Rietschel, M, Cichon, S, Schratt, G & Nöthen, M M 2015, ' Genome-wide analysis implicates microRNAs and their target genes in the development of bipolar disorder ', Translational Psychiatry, vol. 5, pp. e678 . https://doi.org/10.1038/tp.2015.159
Forstner, A J, Hofmann, A, Maaser, A, Sumer, S, Khudayberdiev, S, Mühleisen, T W, Leber, M, Schulze, T G, Strohmaier, J, Degenhardt, F, Treutlein, J, Mattheisen, M, Schumacher, J, Breuer, R, Meier, S, Herms, S, Hoffmann, P, Lacour, A, Witt, S H, Reif, A, Müller-Myhsok, B, Lucae, S, Maier, W, Schwarz, M, Vedder, H, Kammerer-Ciernioch, J, Pfennig, A, Bauer, M, Hautzinger, M, Moebus, S, Priebe, L, Sivalingam, S, Verhaert, A, Schulz, H, Czerski, P M, Hauser, J, Lissowska, J, Szeszenia-Dabrowska, N, Brennan, P, McKay, J D, Wright, A, Mitchell, P B, Fullerton, J M, Schofield, P R, Montgomery, G W, Medland, S E, Gordon, S D, Martin, N G, Krasnov, V, Chuchalin, A, Babadjanova, G, Pantelejeva, G, Abramova, L I, Tiganov, A S, Polonikov, A, Khusnutdinova, E, Alda, M, Cruceanu, C, Rouleau, G A, Turecki, G, Laprise, C, Rivas, F, Mayoral, F, Kogevinas, M, Grigoroiu-Serbanescu, M, Propping, P, Becker, T, Rietschel, M, Cichon, S, Schratt, G & Nöthen, M M 2015, ' Genome-wide analysis implicates microRNAs and their target genes in the development of bipolar disorder ', Translational psychiatry, vol. 5, e678 . https://doi.org/10.1038/tp.2015.159
TRANSLATIONAL PSYCHIATRY
Translational Psychiatry
Translational Psychiatry 5(11), e678 (2015). doi:10.1038/tp.2015.159
Translational Psychiatry 5(11), e678-e678 (2015). doi:10.1038/tp.2015.159

Bipolar disorder (BD) is a severe and highly heritable neuropsychiatric disorder with a lifetime prevalence of 1%. Molecular genetic studies have identified the first BD susceptibility genes. However, the disease pathways remain largely unknown. Accu

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https://pure.au.dk/portal/da/publications/genomewide-analysis-implicates-micrornas-and-their-target-genes-in-the-development-of-bipolar-disorder(7d5dba96-d077-41ec-b2cc-08cdfdb3029c).html

Preliminary Results of a Prospective Multicenter Registry of Lower Esophageal Sphincter Stimulation for Gerd: The Less-Gerd Registry

Autor: Alejandro Nieponice, Jan B. Pedersen, Henning G. Schulz, Andreas Leodolter, Nicole D. Bouvy, Ralf Weise, Joachim Labenz

Publikováno v: Gastroenterology. 152:S470

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https://doi.org/10.1016/s0016-5085(17)31765-1

851 Systematic Association Study of Exonic Variants in Idiopathic Achalasia

Autor: Jessica Becker, Ines Gockel, Markus M. Nöthen, Hauke Lang, Mira M. Wouters, Michael Knapp, Henning G. Schulz, Johannes Schumacher, Michaela Müller, Stefan Niebisch, Guy E. Boeckxstaens

Publikováno v: Gastroenterology. 146:S-146

G A A b st ra ct s but significantly decreased mean liver weight and the mean liver-to-body weight ratio compared to the vehicle group. Furthermore, treatment with SOLI improved glucose metabolism as evidenced by reduction of whole blood glucose leve

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::0a8ddb5dacd96d255688b74156cbc032
https://doi.org/10.1016/s0016-5085(14)60518-7