Zobrazeno 1 - 10
of 1 353
pro vyhledávání: '"Henning D"'
Publikováno v:
Frontiers in Chemistry, Vol 10 (2022)
The small ubiquitin-like modifier (SUMO) is involved in various cellular processes and mediates known non-covalent protein-protein interactions by three distinct binding surfaces, whose interactions are termed class I to class III. While interactors
Externí odkaz:
https://doaj.org/article/6ef8c5a0967a4ad9b64e20c089799196
Autor:
Alice Fabarius, Vanessa Samra, Oliver Drews, Handan Mörz, Miriam Bierbaum, Ali Darwich, Christel Weiss, Susanne Brendel, Helga Kleiner, Wolfgang Seifarth, Wolfgang Greffrath, Wolf-Karsten Hofmann, Clemens A. Schmitt, Henning D. Popp
Publikováno v:
Cancers, Vol 14, Iss 12, p 2883 (2022)
Soluble factors released from irradiated human mesenchymal stromal cells (MSC) may induce genetic instability in human CD34+ cells, potentially mediating hematologic disorders. Recently, we identified four key proteins in the secretome of X-ray-irrad
Externí odkaz:
https://doaj.org/article/261771fdde994dfca4c98c1ec2bb1e4e
Autor:
Vanessa Kohl, Oliver Drews, Victor Costina, Miriam Bierbaum, Ahmed Jawhar, Henning Roehl, Christel Weiss, Susanne Brendel, Helga Kleiner, Johanna Flach, Birgit Spiess, Wolfgang Seifarth, Daniel Nowak, Wolf-Karsten Hofmann, Alice Fabarius, Henning D. Popp
Publikováno v:
International Journal of Molecular Sciences, Vol 22, Iss 11, p 5844 (2021)
Non-targeted effects (NTE) of ionizing radiation may initiate myeloid neoplasms (MN). Here, protein mediators (I) in irradiated human mesenchymal stromal cells (MSC) as the NTE source, (II) in MSC conditioned supernatant and (III) in human bone marro
Externí odkaz:
https://doaj.org/article/157f48e71cea4d3e95e459d07ee793c1
Autor:
Vanessa Kohl, Alice Fabarius, Oliver Drews, Miriam Bierbaum, Ahmed Jawhar, Ali Darwich, Christel Weiss, Johanna Flach, Susanne Brendel, Helga Kleiner, Wolfgang Seifarth, Wolf-Karsten Hofmann, Henning D. Popp
Publikováno v:
Cells, Vol 10, Iss 4, p 827 (2021)
Genotoxic bystander signals released from irradiated human mesenchymal stromal cells (MSC) may induce radiation-induced bystander effects (RIBEs) in human hematopoietic stem and progenitor cells (HSPC), potentially causing leukemic transformation. Al
Externí odkaz:
https://doaj.org/article/324cbdfc921b4985a3e13ddfc358bd33
Autor:
Nicole Naumann, Johannes Lübke, Sofie Baumann, Juliana Schwaab, Oliver Hoffmann, Sebastian Kreil, Vito Dangelo, Lukas Reiter, Peter Bugert, Thomas Kristensen, Karl Sotlar, Verena Haselmann, Sven Schneider, Georgia Metzgeroth, Christel Weiss, Henning D. Popp, Alice Fabarius, Wolf-Karsten Hofmann, Nicholas C. P. Cross, Andreas Reiter, Mohamad Jawhar
Publikováno v:
International Journal of Molecular Sciences, Vol 22, Iss 5, p 2562 (2021)
In systemic mastocytosis (SM), qualitative and serial quantitative assessment of the KIT D816V mutation is of diagnostic and prognostic relevance. We investigated peripheral blood and bone marrow samples of 161 patients (indolent SM (ISM), n = 40; ad
Externí odkaz:
https://doaj.org/article/df45f5bc8edd46bf9a7afe3c33db31a7
Autor:
Henning D. Popp, Mathias Meyer, Susanne Brendel, Wiltrud Prinzhorn, Nicole Naumann, Christel Weiss, Wolfgang Seifarth, Stefan O. Schoenberg, Wolf-K. Hofmann, Thomas Henzler, Alice Fabarius
Publikováno v:
European Journal of Radiology Open, Vol 3, Iss , Pp 134-137 (2016)
Purpose: Computed tomography (CT) scans are an important source of ionizing irradiation (IR) in medicine that can induce a variety of DNA damage in human tissues. With technological improvements CT scans at reduced absorbed doses became feasible pres
Externí odkaz:
https://doaj.org/article/5f6a3edfe98745669ee9127138d6f17f
Autor:
Henning D. Popp, Vanessa Kohl, Nicole Naumann, Johanna Flach, Susanne Brendel, Helga Kleiner, Christel Weiss, Wolfgang Seifarth, Susanne Saussele, Wolf-Karsten Hofmann, Alice Fabarius
Publikováno v:
International Journal of Molecular Sciences, Vol 21, Iss 4, p 1177 (2020)
DNA damage and alterations in the DNA damage response (DDR) are critical sources of genetic instability that might be involved in BCR-ABL1 kinase-mediated blastic transformation of chronic myeloid leukemia (CML). Here, increased DNA damage is detecte
Externí odkaz:
https://doaj.org/article/1b45931184f6452fad970a809b69e1e8
Autor:
Vanessa Kohl, Johanna Flach, Nicole Naumann, Susanne Brendel, Helga Kleiner, Christel Weiss, Wolfgang Seifarth, Daniel Nowak, Wolf-Karsten Hofmann, Alice Fabarius, Henning D. Popp
Publikováno v:
Cancers, Vol 11, Iss 10, p 1493 (2019)
Malignant hematopoietic cells of myelodysplastic syndromes (MDS)/chronic myelomonocytic leukemias (CMML) and acute myeloid leukemias (AML) may be vulnerable to inhibition of poly(ADP ribose) polymerase 1/2 (PARP1/2) and apurinic/apyrimidinic endonucl
Externí odkaz:
https://doaj.org/article/17b35e5ba6d5487ea5f51ae9cba40dbc
Autor:
Joachim Zettler, Simone Eppmann, Alena Busche, Dina Dikovskaya, Volker Dötsch, Henning D Mootz, Tim Sonntag
Publikováno v:
PLoS ONE, Vol 8, Iss 9, p e72925 (2013)
Split intein enabled protein trans-splicing (PTS) is a powerful method for the ligation of two protein fragments, thereby paving the way for various protein modification or protein function control applications. PTS activity is strongly influenced by
Externí odkaz:
https://doaj.org/article/7fec5ef80e634f4696fe4b9b0683c165
Autor:
Christian Nienberg, Anika Retterath, Kira-Sophie Becher, Thorsten Saenger, Henning D. Mootz, Joachim Jose
Publikováno v:
Pharmaceuticals, Vol 9, Iss 3, p 36 (2016)
Human CK2 is a heterotetrameric constitutively active serine/threonine protein kinase and is an emerging target in current anti-cancer drug discovery. The kinase is composed of two catalytic CK2α subunits and two regulatory CK2β subunits. In order
Externí odkaz:
https://doaj.org/article/8ee74dcfae9b4295bd628a4313824a6c