Zobrazeno 1 - 10 of 86 pro vyhledávání: '"Hennie R. Hoogenboom"'
1
Selecting and screening recombinant antibody libraries
Autor: Hennie R. Hoogenboom
Publikováno v: Nature Biotechnology. 23:1105-1116
During the past decade several display methods and other library screening techniques have been developed for isolating monoclonal antibodies (mAbs) from large collections of recombinant antibody fragments. These technologies are now widely exploited
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9392bc26cedd820eb87f938d7eb3bdf0
https://doi.org/10.1038/nbt1126
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2
Optimizing the exogenous antigen loading of monocyte-derived dendritic cells
Autor: Hennie R. Hoogenboom, Detlef Dieckmann, Gerold Schuler, Patrick Chames, Bernhard Ring, Erwin S. Schultz, Gerhard Held
Publikováno v: International Immunology. 17:621-635
Dendritic cell (DC) vaccination, i.e. the adoptive transfer of antigen-loaded DC, is still at an early stage and requires standardization. In this study, we investigated the exogenous loading of monocyte-derived DCs with HLA class I- and II-restricte
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4094ccf6533a786ae7287a212e0bdbfb
https://doi.org/10.1093/intimm/dxh243
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4
A Major Histocompatibility Complex·Peptide-restricted Antibody and T Cell Receptor Molecules Recognize Their Target by Distinct Binding Modes
Autor: Gabriele Wille, Claudia Alings, Gerhard Held, Pierre Coulie, Patrick Chames, Martin Hülsmeyer, Hennie R. Hoogenboom, Barbara Uchanska-Ziegler, Robyn L. Stanfield, Andreas Ziegler, Roman C. Hillig, Wolfram Saenger
Publikováno v: Journal of Biological Chemistry. 280:2972-2980
Antibodies with T cell receptor-like specificity possess a considerable diagnostic and therapeutic potential, but the structural basis of the interaction between an antibody and an histocompatibility antigen has so far not been determined. We present
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::11ffabee6bced4a162b13084184fcf01
https://doi.org/10.1074/jbc.m411323200
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5
Construction and diversification of yeast cell surface displayed libraries by yeast mating: application to the affinity maturation of Fab antibody fragments
Autor: Mieke Steukers, Simon E. Hufton, Hennie R. Hoogenboom, Twan van den Beucken, Lydia Blaise, Anita Wehnert
Publikováno v: Gene. 342:211-218
Yeast display is a powerful technology for the affinity maturation of human antibody fragments. However, the technology thus far has been limited by the size of antibody libraries that can be generated, as using current transformation protocols libra
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5b17170203acaba487d33bbaf953f4f4
https://doi.org/10.1016/j.gene.2004.08.014
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6
Isolation of human antibodies to tumor-associated endothelial cell markers by in vitro human endothelial cell selection with phage display libraries
Autor: Edith van der Linden, Sietske Satijn, Hennie R. Hoogenboom, Patrick Chames, H.H.C. Lichtenbeld, Angelique Huijbers, Jan-Willem Arends, Ricardo Mutuberria
Publikováno v: Journal of Immunological Methods. 287:31-47
Human antibodies selectively targeting angiogenic vessels hold great promise for the immunotherapy of human malignancies and can help to elucidate the molecular mechanisms regulating angiogenesis. By selecting a large antibody phage display library o
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::366f065dc4b6cf220ae1d9b31ca77533
https://doi.org/10.1016/j.jim.2004.01.011
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7
Target validation for genomics using peptide-specific phage antibodies: A study of five gene products overexpressed in colorectal cancer
Autor: Simon E. Hufton, Andrea J Gerbers, Judy R. van Beijnum, Adriaan P. de Bruïne, Peter T.M. Moerkerk, Jan-Willem Arends, Hennie R. Hoogenboom
Publikováno v: International Journal of Cancer. 101:118-127
Genomic approaches are providing a wealth of information on differential gene expression in cancer. To identify the most interesting genes amongst the many identified, high-throughput methods for analysis of genes at the translational level are requi
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::4550ee9fc5fb82b1e2220025034a565c
https://doi.org/10.1002/ijc.10584
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8
TCR-Like Human Antibodies Expressed on Human CTLs Mediate Antibody Affinity-Dependent Cytolytic Activity
Autor: Hennie R. Hoogenboom, Gerold Schuler, Gertrudis Rojas, Detlef Dieckmann, Ralph A. Willemsen, Reinder L. H. Bolhuis, Patrick Chames, Louise Rem
Publikováno v: Journal of Immunology, 169, 1110-1118. American Association of Immunologists
The permanent genetic programming via gene transfer of autologous T cells with cell surface receptors directed toward tumor-related Ags holds great promise for the development of more-specific tumor therapies. In this study we have explored the use o
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::53d37df0fde0824d2b87c3e8a624317b
https://doi.org/10.4049/jimmunol.169.2.1110
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9
Phage Display Technology for Target Discovery in Drug Delivery Research
Autor: Hennie R. Hoogenboom, Arjan W. Griffioen, Jan-Willem Arends, Ricardo Mutuberria
Publikováno v: Drug Targeting: Organ-Specific Strategies, Volume 12
Phage display technology has revolutionized the search for proteins, peptides, and antibodies that bind to molecular targets.The creation of ligand-displaying libraries in combination with powerful selection methods has opened up a wide range of poss
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::4c34de2063d99e53005746c430286d8c
https://doi.org/10.1002/352760006x.ch10
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10
In vitro characterisation of a monovalent and bivalent form of a fully human anti Ep-CAM phage antibody
Autor: Edith van der Linden, R C Roovers, Adriaan P. de Bruïne, Jan-Willem Arends, Hennie R. Hoogenboom
Publikováno v: Cancer Immunology, Immunotherapy. 50:51-59
Antibodies to tumour-associated antigens are increasingly being used as targeting vehicles for the visualisation and for therapy of human solid tumours. The epithelial cell adhesion molecule (Ep-CAM) is an antigen that is overexpressed on a variety o
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6c108ff036e8816596845c17ac2fa801
https://doi.org/10.1007/s002620000160
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