Atazanavir-induced unconjugated hyperbilirubinemia prevents vascular hyporeactivity during experimental human endotoxemia

Autor: Mirrin J. Dorresteijn, Douwe Dekker, Jelle Zwaag, Suzanne Heemskerk, Hennie M.J. Roelofs, Paul Smits, Johannes G. van der Hoeven, Frank A.D.T.G. Wagener, Peter Pickkers

Publikováno v: Frontiers in Immunology, Vol 14 (2023)

ObjectiveInflammation-induced free radical release is important in the pathogenesis of several diseases, including atherosclerosis and sepsis. Heme oxygenase (HO) breaks down heme into carbon monoxide, iron, and biliverdin. Biliverdin IXα is directl

Externí odkaz: https://doaj.org/article/e67545b11d364f339c725201a0a1264d

Iron handling by the human kidney: glomerular filtration and tubular reabsorption both contribute to urinary iron excretion

Autor: Ewout J. Hoorn, Tom Nijenhuis, Rachel P. L. van Swelm, Sanne van Raaij, Stephen B. Walsh, Bart J. Biemond, Dorine W. Swinkels, Saskia E M Schols, Erwin T. Wiegerinck, Hennie M.J. Roelofs, Alexander J. Rennings

Publikováno v: American journal of physiology. Renal physiology, 316(3), F606-F614. American Physiological Society
American Journal of Physiology-Renal Physiology, 316(3), F606-F614. American Physiological Society
American Journal of Physiology : Renal Physiology, 316, 606-614
American Journal of Physiology : Renal Physiology, 316, 3, pp. 606-614
van Raaij, S E G, Rennings, A J, Biemond, B J, Schols, S E M, Wiegerinck, E T G, Roelofs, H M J, Hoorn, E J, Walsh, S B, Nijenhuis, T, Swinkels, D W & van Swelm, R P L 2019, ' Iron handling by the human kidney: Glomerular filtration and tubular reabsorption both contribute to urinary iron excretion ', American Journal of Physiology-Renal Physiology, vol. 316, no. 3, pp. F606-F614 . https://doi.org/10.1152/ajprenal.00425.2018

In physiological conditions, circulating iron can be filtered by the glomerulus and is almost completely reabsorbed by the tubular epithelium to prevent urinary iron wasting. Increased urinary iron concentrations have been associated with renal injur

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::487dff9141f60a8d5eca1db9aa3fea14
https://pubmed.ncbi.nlm.nih.gov/30623722

No Clinical or Biochemical Evidence for Essential Fatty Acid Deficiency in Home Patients Who Depend on Long-Term Mixed Olive Oil– and Soybean Oil–Based Parenteral Nutrition

Autor: Helena L. Fisk, Geert J. A. Wanten, E.D. Olthof, Hennie M.J. Roelofs, Philip C. Calder

Publikováno v: Jpen, Journal of Parenteral and Enteral Nutrition, 40, 982-8
Jpen, Journal of Parenteral and Enteral Nutrition, 40, 7, pp. 982-8

Contains fulltext : 171051.pdf (Publisher’s version ) (Closed access) BACKGROUND: Home parenteral nutrition (HPN) patients depend on lipid emulsions as part of their parenteral nutrition regimen to provide essential fatty acids (EFAs). Mixed-oil so

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c5d697ce90a28bad1d80973adcef30d1
https://doi.org/10.1177/0148607115581375

Tubular Injury Biomarkers to Detect Gentamicin-Induced Acute Kidney Injury in the Neonatal Intensive Care Unit

Autor: Arno van Heijst, Hennie M.J. Roelofs, Linda Koster-Kamphuis, Wim van Oeveren, Suzanne Heemskerk, Martijn P.W.J.M. Bouw, Esther Peters, Diana Jansen, Peter Pickkers

Publikováno v: American Journal of Perinatology, 33, 2, pp. 180-7
American Journal of Perinatology, 33, 180-7

Contains fulltext : 171867.pdf (Publisher’s version ) (Closed access) Objective We evaluated whether urinary excretion of tubular injury markers could be useful for early detection of gentamicin (GM)-induced renal damage in neonates. Study Design W

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::998e51adf9fda2ecfbe0d712effe6c2b
https://hdl.handle.net/2066/171867

Supplemental antioxidants do not ameliorate colitis development in HLA-B27 transgenic rats despite extremely low glutathione levels in colonic mucosa5

Autor: Carolien Vink, Roelof van der Meer, Hennie M.J. Roelofs, Arjan J. Schonewille, Robert-Jan M. Brummer, Marloes A. A. Schepens, Ingeborg M. J. Bovee-Oudenhoven

Publikováno v: Inflammatory Bowel Diseases. 17:2065-2075

Background: Oxidative stress is presumed to play an important role in inflammatory bowel disease (IBD). Accordingly, antioxidant supplementation might be protective. Dietary calcium inhibited colitis development in HLA-B27 transgenic rats, an animal

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::b63a21a75427b23e4fe36b031e07494b
https://doi.org/10.1002/ibd.21584