Identification of diverse lipid‐binding modes in the groove of zinc α 2 glycoprotein reveals its functional versatility

Autor: Stephen J. Perkins, Sharon M. Kelly, Jayesh Gor, Lindsay C. McDermott, Henna Zahid, Kersti Karu, Andy M. Lau

Publikováno v: The FEBS Journal. 289:1876-1896

ZAG is a multifunctional glycoprotein with a class I MHC-like protein fold and an α1-α2 lipid-binding groove. The intrinsic ZAG ligand is unknown. Our previous studies showed that ZAG binds the dansylated C11 fatty acid, DAUDA, differently to the b

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::24e7b864399385d3fea0833e76e3dd9a
https://doi.org/10.1111/febs.16293

Identification of diverse lipid-binding modes in the groove of zinc α

Autor: Henna, Zahid, Andy M, Lau, Sharon M, Kelly, Kersti, Karu, Jayesh, Gor, Stephen J, Perkins, Lindsay C, McDermott

Publikováno v: The FEBS journalReferences. 289(7)

ZAG is a multifunctional glycoprotein with a class I MHC-like protein fold and an α1-α2 lipid-binding groove. The intrinsic ZAG ligand is unknown. Our previous studies showed that ZAG binds the dansylated C

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::8b03edff7fce6c69868fd579d0aa5c7c
https://pubmed.ncbi.nlm.nih.gov/34817923

Zinc-induced oligomerization of zinc α2 glycoprotein reveals multiple fatty acid-binding sites

Autor: Jayesh Gor, Lindsay C. McDermott, Layeque Miah, Alex F. Drake, Henna Zahid, Stephen J. Perkins, Lea Brochard, Tam T. T. Bui, Andy M. Lau, Debolina Hati

Publikováno v: Zahid, H, Miah, L, Lau, A M, Brochard, L, Hati, D, Bui, T T T, Drake, A F, Gor, J, Perkins, S J & McDermott, L C 2016, ' Zinc-induced oligomerization of zinc α2 glycoprotein reveals multiple fatty acid-binding sites ', Biochemical Journal, vol. 473, no. 1, pp. 43-54 . https://doi.org/10.1042/BJ20150836

Zinc α2 glycoprotein (ZAG) is an adipokine with a class I MHC protein fold and is associated with obesity and diabetes. Although its intrinsic ligand remains unknown, ZAG binds the dansylated C11 fatty acid 11-(dansylamino)undecanoic acid (DAUDA) in

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3b7bf4d6a898b58a03d82e37d3b77888
https://kclpure.kcl.ac.uk/ws/files/46883935/BJ20150836full_Zinc_protein_2015.pdf