Zobrazeno 1 - 10
of 21
pro vyhledávání: '"Henna M. Moore"'
Autor:
Taras A. Redchuk, Maksim M. Karasev, Polina V. Verkhusha, Sara K. Donnelly, Maren Hülsemann, Jori Virtanen, Henna M. Moore, Maria K. Vartiainen, Louis Hodgson, Vladislav V. Verkhusha
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-12 (2020)
Optogenetic approaches to control protein-protein interactions usually require overexpression of the target proteins. Here the authors integrate intrabodies into near-infrared- and blue-light activatable optogenetic tools to control endogenous protei
Externí odkaz:
https://doaj.org/article/6f20a13284cc4e2a9ddb3638c37c57ca
Autor:
Maria Sokolova, Henna M. Moore, Bina Prajapati, Joseph Dopie, Leena Meriläinen, Mikko Honkanen, Rita Cerejeira Matos, Minna Poukkula, Ville Hietakangas, Maria K. Vartiainen
Publikováno v:
iScience, Vol 9, Iss , Pp 63-70 (2018)
Summary: Actin has been linked to processes spanning the whole gene expression cascade, from regulating specific transcription factors, such as myocardin-related transcription factor, to chromatin remodeling and RNA polymerase function. However, whet
Externí odkaz:
https://doaj.org/article/0377805f70d5493dbdd210059f1f9fdb
Autor:
Marikki Laiho, Paul Sirajuddin, Henna M. Moore, Taija af Hällström, Zhewei Zhang, Sari Jäämaa, Hester Liu, Laureen Colis, Karita Peltonen
Activation of the p53 pathway has been considered a therapeutic strategy to target cancers. We have previously identified several p53-activating small molecules in a cell-based screen. Two of the compounds activated p53 by causing DNA damage, but thi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::28e7d749d4d008017b523486220b60e1
https://doi.org/10.1158/1535-7163.c.6536851.v1
https://doi.org/10.1158/1535-7163.c.6536851.v1
Autor:
Marikki Laiho, Paul Sirajuddin, Henna M. Moore, Taija af Hällström, Zhewei Zhang, Sari Jäämaa, Hester Liu, Laureen Colis, Karita Peltonen
Supplementary Figures S1-S3. Supplementary Figure 1. BMH-9, BMH-22 and BMH-23 cause a reduction in RPA194 half life. Supplementary Figure 2. BMH-9, BMH-22 and BMH-23 do not activate the DNA damage response. Supplementary Figure 3. p53 activation by N
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9b53ba1e13f4e77c38c059113b3a5987
https://doi.org/10.1158/1535-7163.22501639.v1
https://doi.org/10.1158/1535-7163.22501639.v1
Autor:
Rita Cerejeira Matos, Mikko Honkanen, Minna Poukkula, Maria Sokolova, Ville Hietakangas, Henna M. Moore, Leena Meriläinen, Bina Prajapati, Joseph Dopie, Maria K. Vartiainen
Publikováno v:
iScience
iScience, Vol 9, Iss, Pp 63-70 (2018)
iScience, Vol 9, Iss, Pp 63-70 (2018)
Summary Actin has been linked to processes spanning the whole gene expression cascade, from regulating specific transcription factors, such as myocardin-related transcription factor, to chromatin remodeling and RNA polymerase function. However, wheth
Autor:
Jori Virtanen, Maren Hülsemann, Polina V Verkhusha, Maria K. Vartiainen, Louis Hodgson, Vladislav V. Verkhusha, Henna M. Moore, Taras A. Redchuk, Sara K. Donnelly, Maksim M. Karasev
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-12 (2020)
Nature Communications
Nature Communications
Techniques of protein regulation, such as conditional gene expression, RNA interference, knock-in and knock-out, lack sufficient spatiotemporal accuracy, while optogenetic tools suffer from non-physiological response due to overexpression artifacts.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::69f27d34ad99881cfb912d72a71b52c9
http://hdl.handle.net/10138/317811
http://hdl.handle.net/10138/317811
Autor:
Henna M. Moore, Maria K. Vartiainen
Publikováno v:
Nature Cell Biology. 19:1386-1388
After mitosis, the nucleus must be rebuilt and chromatin decondensed to permit interphase genomic functions, but decondensation mechanisms are poorly understood. Now, the traditional cytoskeletal protein actin is shown to form transient nuclear filam
Autor:
Paul Sirajuddin, Henna M. Moore, Karita Peltonen, Zhewei Zhang, Hester Liu, Marikki Laiho, Sari Jäämaa, Laureen Colis, Taija af Hällström
Publikováno v:
Molecular Cancer Therapeutics. 13:2537-2546
Activation of the p53 pathway has been considered a therapeutic strategy to target cancers. We have previously identified several p53-activating small molecules in a cell-based screen. Two of the compounds activated p53 by causing DNA damage, but thi
Publikováno v:
Oncogene. 30:790-805
The ubiquitin-proteasome pathway is essential for most cellular processes, including protein quality control, cell cycle, transcription, signaling, protein transport, DNA repair and stress responses. Hampered proteasome activity leads to the accumula
Autor:
Marikki Laiho, Ulpu Saarialho-Kere, Sari Suomela, Päivi M. Järvinen, Henna M. Moore, Leena Latonen
Publikováno v:
Photodermatology, Photoimmunology & Photomedicine. 26:70-77
Background: Cysteine-rich protein 1 (CRP1) is a growth-inhibitory cytoskeletal protein that is induced by ultraviolet (UV) C radiation radiation in fibroblasts. Our aim was to investigate the effects of UV radiation on CRP1 in keratinocytes, the main