Guanine can direct binding specificity of Ru-dppz complexes to DNA through steric effects

Autor: Hall, James P., Gurung, Sarah P., Henle, Jessica, Poidl, Patrick, Andersson, Johanna, Lincoln, Per, Winter, Graeme, Sorensen, Thomas, Cardin, David J., Brazier, John A., Cardin, Christine J.

X-ray crystal structures of three Λ-[Ru(L)2dppz]2+ complexes (L=phen, bpy) bound to d((5BrC)GGC/GCCG) show the compounds intercalated at a 5´-CG-3´ step. The compounds bind through canted intercalation, with the binding angle determined by the gua

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=core_ac_uk__::d249ec60ad8cf56b2df2264a91da3e10
https://centaur.reading.ac.uk/68810/17/Hall_et_al-2017-Chemistry_-_A_European_Journal.pdf

Guanine Can Direct Binding Specificity of Ru-dipyridophenazine (dppz) Complexes to DNA through Steric Effects.

Autor: Hall JP; Department of Chemistry, University of Reading, Whiteknights, Reading, RG6 6AD, UK.; Diamond Light Source, Harwell Science and Innovation Campus, Fermi Avenue, Didcot, OX11 0QX, UK., Gurung SP; Department of Chemistry, University of Reading, Whiteknights, Reading, RG6 6AD, UK.; Diamond Light Source, Harwell Science and Innovation Campus, Fermi Avenue, Didcot, OX11 0QX, UK., Henle J; Department of Chemistry, University of Reading, Whiteknights, Reading, RG6 6AD, UK., Poidl P; Department of Chemistry, University of Reading, Whiteknights, Reading, RG6 6AD, UK., Andersson J; Department of Chemistry and Chemical Engineering, Chalmers University of Technology, 412-96, Gothenberg, Sweden.; Department of Chemistry - BMC, Uppsala University, Box 576, 751 23, Uppsala, Sweden., Lincoln P; Department of Chemistry and Chemical Engineering, Chalmers University of Technology, 412-96, Gothenberg, Sweden., Winter G; Diamond Light Source, Harwell Science and Innovation Campus, Fermi Avenue, Didcot, OX11 0QX, UK., Sorensen T; Diamond Light Source, Harwell Science and Innovation Campus, Fermi Avenue, Didcot, OX11 0QX, UK., Cardin DJ; Department of Chemistry, University of Reading, Whiteknights, Reading, RG6 6AD, UK., Brazier JA; Department of Pharmacy, University of Reading, Whiteknights, Reading, RG6 6AD, UK., Cardin CJ; Department of Chemistry, University of Reading, Whiteknights, Reading, RG6 6AD, UK.

Publikováno v: Chemistry (Weinheim an der Bergstrasse, Germany) [Chemistry] 2017 Apr 11; Vol. 23 (21), pp. 4981-4985. Date of Electronic Publication: 2017 Feb 06.