Zobrazeno 1 - 10
of 57
pro vyhledávání: '"Henk-Jan Boele"'
Autor:
Francesca Romana Fiocchi, Nikki E. S. van Dorp, Stephanie Dijkhuizen, Maurits van den Berg, Aaron Wong, Chris I. De Zeeuw, Henk-Jan Boele
Publikováno v:
Frontiers in Behavioral Neuroscience, Vol 18 (2024)
The delicate balance between discrimination and generalization of responses is crucial for survival in our ever-changing environment. In particular, it is important to understand how stimulus discrimination affects the level of stimulus generalizatio
Externí odkaz:
https://doaj.org/article/ff8788c6d5464c248e575d0fe3a3dee1
Autor:
Alice Geminiani, Claudia Casellato, Henk-Jan Boele, Alessandra Pedrocchi, Chris I De Zeeuw, Egidio D'Angelo
Publikováno v:
PLoS Computational Biology, Vol 20, Iss 4, p e1011277 (2024)
According to the motor learning theory by Albus and Ito, synaptic depression at the parallel fibre to Purkinje cells synapse (pf-PC) is the main substrate responsible for learning sensorimotor contingencies under climbing fibre control. However, rece
Externí odkaz:
https://doaj.org/article/4b567e9a741349cc97edf07de3261d4b
Autor:
Thomas J. Pisano, Austin T. Hoag, Zahra M. Dhanerawala, Sara R. Guariglia, Caroline Jung, Henk-Jan Boele, Kelly M. Seagraves, Jessica L. Verpeut, Samuel S.-H. Wang
Publikováno v:
STAR Protocols, Vol 3, Iss 2, Pp 101289- (2022)
Summary: Transsynaptic viral tracing requires tissue sectioning, manual cell counting, and anatomical assignment, all of which are time intensive. We describe a protocol for BrainPipe, a scalable software for automated anatomical alignment and object
Externí odkaz:
https://doaj.org/article/c091740fc02a4919ade694dc767b0725
Autor:
Thomas J. Pisano, Zahra M. Dhanerawala, Mikhail Kislin, Dariya Bakshinskaya, Esteban A. Engel, Ethan J. Hansen, Austin T. Hoag, Junuk Lee, Nina L. de Oude, Kannan Umadevi Venkataraju, Jessica L. Verpeut, Freek E. Hoebeek, Ben D. Richardson, Henk-Jan Boele, Samuel S.-H. Wang
Publikováno v:
Cell Reports, Vol 36, Iss 12, Pp 109721- (2021)
Summary: Cerebellar outputs take polysynaptic routes to reach the rest of the brain, impeding conventional tracing. Here, we quantify pathways between the cerebellum and forebrain by using transsynaptic tracing viruses and a whole-brain analysis pipe
Externí odkaz:
https://doaj.org/article/f6fbdb31b6d84daba6120233ef23a1ec
Autor:
Henk-Jan Boele, Sangyun Joung, Joanne E. Fil, Austin T. Mudd, Stephen A. Fleming, Sebastiaan K. E. Koekkoek, Ryan N. Dilger
Publikováno v:
Frontiers in Behavioral Neuroscience, Vol 15 (2021)
Introduction: Pigs have been an increasingly popular preclinical model in nutritional neuroscience, as their anatomy, physiology, and nutrition requirements are highly comparable to those of humans. Eyeblink conditioning is one of the most well-valid
Externí odkaz:
https://doaj.org/article/740cecac20ec4582b139cb3ec607adaf
Autor:
Gerrit Cornelis Beekhof, Catarina Osório, Joshua J White, Scott van Zoomeren, Hannah van der Stok, Bilian Xiong, Ingo HMS Nettersheim, Willem Ashwin Mak, Marit Runge, Francesca Romana Fiocchi, Henk-Jan Boele, Freek E Hoebeek, Martijn Schonewille
Publikováno v:
eLife, Vol 10 (2021)
Distinct populations of Purkinje cells (PCs) with unique molecular and connectivity features are at the core of the modular organization of the cerebellum. Previously, we showed that firing activity of PCs differs between ZebrinII-positive and Zebrin
Externí odkaz:
https://doaj.org/article/3e63f4188e7347519436936b6269724f
Autor:
Giorgio Grasselli, Henk-Jan Boele, Heather K Titley, Nora Bradford, Lisa van Beers, Lindsey Jay, Gerco C Beekhof, Silas E Busch, Chris I De Zeeuw, Martijn Schonewille, Christian Hansel
Publikováno v:
PLoS Biology, Vol 18, Iss 1, p e3000596 (2020)
Neurons store information by changing synaptic input weights. In addition, they can adjust their membrane excitability to alter spike output. Here, we demonstrate a role of such "intrinsic plasticity" in behavioral learning in a mouse model that allo
Externí odkaz:
https://doaj.org/article/40e48f6ef570448790263fe844f50d3b
Autor:
Bin Wu, François GC Blot, Aaron Benson Wong, Catarina Osório, Youri Adolfs, R Jeroen Pasterkamp, Jana Hartmann, Esther BE Becker, Henk-Jan Boele, Chris I De Zeeuw, Martijn Schonewille
Publikováno v:
eLife, Vol 8 (2019)
Despite the canonical homogeneous character of its organization, the cerebellum plays differential computational roles in distinct sensorimotor behaviors. Previously, we showed that Purkinje cell (PC) activity differs between zebrin-negative (Z–) a
Externí odkaz:
https://doaj.org/article/a9026aa4734a4afca2461feffd8a1e97
Dysfunctional cerebellar Purkinje cells contribute to autism-like behaviour in Shank2-deficient mice
Autor:
Saša Peter, Michiel M. ten Brinke, Jeffrey Stedehouder, Claudia M. Reinelt, Bin Wu, Haibo Zhou, Kuikui Zhou, Henk-Jan Boele, Steven A. Kushner, Min Goo Lee, Michael J. Schmeisser, Tobias M. Boeckers, Martijn Schonewille, Freek E. Hoebeek, Chris I. De Zeeuw
Publikováno v:
Nature Communications, Vol 7, Iss 1, Pp 1-14 (2016)
Mutations in SHANK2 are associated with autism spectrum disorders (ASD). Here, Peter et al. show that selective loss of Shank2in Purkinje cells of the mouse cerebellum leads to deficits in plasticity, motor behaviour, and a social behaviour phenotype
Externí odkaz:
https://doaj.org/article/af668473ae724b5ea8dc88a41fcf7ba7
Autor:
Michiel M. ten Brinke, Henk-Jan Boele, Jochen K. Spanke, Jan-Willem Potters, Katja Kornysheva, Peer Wulff, Anna C.H.G. IJpelaar, Sebastiaan K.E. Koekkoek, Chris I. De Zeeuw
Publikováno v:
Cell Reports, Vol 13, Iss 9, Pp 1977-1988 (2015)
Three decades of electrophysiological research on cerebellar cortical activity underlying Pavlovian conditioning have expanded our understanding of motor learning in the brain. Purkinje cell simple spike suppression is considered to be crucial in the
Externí odkaz:
https://doaj.org/article/149b5c83b21141b6a28ae3f4f47d540b