Zobrazeno 1 - 10
of 62
pro vyhledávání: '"Henk Van Faassen"'
Autor:
Marzia Martina, Umberto Banderali, Alvaro Yogi, Mehdi Arbabi Ghahroudi, Hong Liu, Traian Sulea, Yves Durocher, Greg Hussack, Henk van Faassen, Balu Chakravarty, Qing Yan Liu, Umar Iqbal, Binbing Ling, Etienne Lessard, Joey Sheff, Anna Robotham, Debbie Callaghan, Maria Moreno, Tanya Comas, Dao Ly, Danica Stanimirovic
Publikováno v:
Advanced Science, Vol 11, Iss 40, Pp n/a-n/a (2024)
Abstract Genetic studies have identified the voltage‐gated sodium channel 1.7 (Nav1.7) as pain target. Due to the ineffectiveness of small molecules and monoclonal antibodies as therapeutics for pain, single‐domain antibodies (VHHs) are developed
Externí odkaz:
https://doaj.org/article/25473da9710e4c68b7eed6b4056350ba
Autor:
Martin A. Rossotti, Henk van Faassen, Anh T. Tran, Joey Sheff, Jagdeep K. Sandhu, Diana Duque, Melissa Hewitt, Xiaoxue Wen, Jegarubee Bavananthasivam, Saina Beitari, Kevin Matte, Geneviève Laroche, Patrick M. Giguère, Christian Gervais, Matthew Stuible, Julie Guimond, Sylvie Perret, Greg Hussack, Marc-André Langlois, Yves Durocher, Jamshid Tanha
Publikováno v:
Communications Biology, Vol 5, Iss 1, Pp 1-19 (2022)
Isolation and extensive characterization of a collection of 37 anti-SARS-CoV-2 spike glycoprotein nanobodies show broad neutralization efficacies in vitro and in vivo in a hamster model of SARS-CoV-2 infection.
Externí odkaz:
https://doaj.org/article/2f48dc9abf474ef9b75e5e6b1b33d3f4
Autor:
Greg Hussack, Martin A. Rossotti, Henk van Faassen, Tomohiko Murase, Luiz Eugenio, Joseph D. Schrag, Kenneth K.-S. Ng, Jamshid Tanha
Publikováno v:
Frontiers in Microbiology, Vol 14 (2023)
Externí odkaz:
https://doaj.org/article/b5e3e4ed42404d8193860eb3fc082ef5
Autor:
Greg Hussack, Martin A. Rossotti, Henk van Faassen, Tomohiko Murase, Luiz Eugenio, Joseph D. Schrag, Kenneth K.-S. Ng, Jamshid Tanha
Publikováno v:
Frontiers in Microbiology, Vol 14 (2023)
Crystal structures of camelid heavy-chain antibody variable domains (VHHs) bound to fragments of the combined repetitive oligopeptides domain of Clostridioides difficile toxin A (TcdA) reveal that the C-terminus of VHH A20 was located 30 Å away from
Externí odkaz:
https://doaj.org/article/40e3d0c986f54e86b2d0109a94a5ac34
Autor:
Joey Sheff, Ping Wang, Ping Xu, Melanie Arbour, Luke Masson, Henk van Faassen, Greg Hussack, Kristin Kemmerich, Eric Brunette, Danica Stanimirovic, Jennifer J. Hill, John Kelly, Feng Ni
Publikováno v:
Scientific Reports, Vol 11, Iss 1, Pp 1-13 (2021)
Abstract Ligand-activated signaling through the type 1 insulin-like growth factor receptor (IGF1R) is implicated in many physiological processes ranging from normal human growth to cancer proliferation and metastasis. IGF1R has also emerged as a targ
Externí odkaz:
https://doaj.org/article/abc8b420f9a841a1ad3480689cc4f109
Autor:
Alvaro Yogi, Greg Hussack, Henk van Faassen, Arsalan S. Haqqani, Christie E. Delaney, Eric Brunette, Jagdeep K. Sandhu, Melissa Hewitt, Traian Sulea, Kristin Kemmerich, Danica B. Stanimirovic
Publikováno v:
Pharmaceutics, Vol 14, Iss 7, p 1452 (2022)
The ability of drugs and therapeutic antibodies to reach central nervous system (CNS) targets is greatly diminished by the blood–brain barrier (BBB). Receptor-mediated transcytosis (RMT), which is responsible for the transport of natural protein li
Externí odkaz:
https://doaj.org/article/cebfc66ae2ca43619249a1d974dd42db
Autor:
Joey G. Sheff, John F. Kelly, Anna Robotham, Traian Sulea, Félix Malenfant, Denis L’Abbé, Mélanie Duchesne, Alex Pelletier, Jean Lefebvre, Andrea Acel, Marie Parat, Mylene Gosselin, Cunle Wu, Yves Fortin, Jason Baardsnes, Henk Van Faassen, Shannon Awrey, Shawn C. Chafe, Paul C. McDonald, Shoukat Dedhar, Anne E.G. Lenferink
Publikováno v:
mAbs, Vol 13, Iss 1 (2021)
Human carbonic anhydrase (hCAIX), an extracellular enzyme that catalyzes the reversible hydration of CO2, is often overexpressed in solid tumors. This enzyme is instrumental in maintaining the survival of cancer cells in a hypoxic and acidic tumor mi
Externí odkaz:
https://doaj.org/article/05ceb9ddaa0e4ba48f2d8c3227f954cc
Autor:
Greg Hussack, Shannon Ryan, Henk van Faassen, Martin Rossotti, C Roger MacKenzie, Jamshid Tanha
Publikováno v:
PLoS ONE, Vol 13, Iss 12, p e0208978 (2018)
An increasing number of antibody-based therapies are being considered for controlling bacterial infections, including Clostridium difficile by targeting toxins A and B. In an effort to develop novel C. difficile immunotherapeutics, we previously isol
Externí odkaz:
https://doaj.org/article/de3cc46448984acaa62e428dea5457e9
Autor:
Greg Hussack, Toya Nath Baral, Jason Baardsnes, Henk van Faassen, Shalini Raphael, Kevin A. Henry, Jianbing Zhang, C. Roger MacKenzie
Publikováno v:
Frontiers in Immunology, Vol 8 (2017)
ABTAG is a camelid single-domain antibody (sdAb) that binds to bovine serum albumin (BSA) with low picomolar affinity. In surface plasmon resonance (SPR) analyses using BSA surfaces, bound ABTAG can be completely dissociated from the BSA surfaces at
Externí odkaz:
https://doaj.org/article/c3827df654004995833a10e4a82315bd
Autor:
Kevin A Henry, Traian Sulea, Henk van Faassen, Greg Hussack, Enrico O Purisima, C Roger MacKenzie, Mehdi Arbabi-Ghahroudi
Publikováno v:
PLoS ONE, Vol 11, Iss 9, p e0163113 (2016)
Staphylococcal protein A (SpA) and streptococcal protein G (SpG) affinity chromatography are the gold standards for purifying monoclonal antibodies (mAbs) in therapeutic applications. However, camelid VHH single-domain Abs (sdAbs or VHHs) are not bou
Externí odkaz:
https://doaj.org/article/2d1ae8285664432b857d78cf57c413ed