Zobrazeno 1 - 10
of 19
pro vyhledávání: '"Henk Sipma"'
Autor:
Sara Vanlingen, Geert Callewaert, Henk Sipma, Patrick De Smet, Humbert De Smedt, Ludwig Missiaen, Jan B. Parys
Publikováno v:
Biochemical Pharmacology. 61:803-809
Three different genes encode the inositol 1,4,5-trisphosphate (IP 3 ) receptor (IP 3 R), an intracellular Ca 2+ channel involved in cellular Ca 2+ signaling. The IP 3 -binding characteristics of the various IP 3 R isoforms differ, but until now no sp
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9a21d065c14363268afa4415a21da077
https://doi.org/10.1016/s0006-2952(01)00540-8
https://doi.org/10.1016/s0006-2952(01)00540-8
Autor:
Ludwig Missiaen, Ilse Sienaert, Jan B. Parys, Sara Vanlingen, Humbert De Smedt, Henk Sipma, Patrick De Smet
Publikováno v:
Journal of Biological Chemistry. 274:12157-12162
A recombinant protein (Lbs-1) containing the N-terminal 581 amino acids of the mouse type 1 inositol 1,4,5-trisphosphate receptor (IP3R-1), including the complete IP3-binding site, was expressed in the soluble fraction of E. coli. The characteristics
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b3312c9d947fad9efe01837b40b279fe
https://doi.org/10.1074/jbc.274.17.12157
https://doi.org/10.1074/jbc.274.17.12157
Autor:
P De Smet, Jan B. Parys, H De Smedt, Henk Sipma, E. Hill, Tommie V. McCarthy, Geert Callewaert, Ludwig Missiaen
Publikováno v:
Pfl�gers Archiv European Journal of Physiology. 437:691-694
There is still no agreement on the mechanism of the intracellular action of low concentrations of inositol 1,4,5-trisphosphate (IP3). Intracellular Ca2+ stores may transiently release some Ca2+ before they become insensitive to IP3. Alternatively, st
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d23c5c07f31a1eaebd2ff2bdb0103c09
https://doi.org/10.1007/s004240050833
https://doi.org/10.1007/s004240050833
Autor:
Sara Vanlingen, Henk Sipma, Rik Casteels, Jan B. Parys, H De Smedt, P De Smet, Ludwig Missiaen
Publikováno v:
Cell Calcium. 25:107-114
The binding of inositol 1,4,5-trisphosphate (IP3) to the IP3 receptor (IP3R) is modulated by various compounds. Until now, limited progress has been made concerning the isoform-specific effects of these modulators. In this study, we examined how [3H]
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::86834ba0a53b25e515077e72a114b145
https://doi.org/10.1054/ceca.1998.0010
https://doi.org/10.1054/ceca.1998.0010
Autor:
Leo E. Deelman, Jan B. Parys, Robert H. Henning, Ludwig Missiaen, Henk Sipma, Humbert De Smedt, Rik Casteels, Sara Vanlingen
Publikováno v:
Cell calcium, 23(1), 11-21. Churchill Livingstone
Prolonged stimulation of rat A7r5 aortic smooth muscle cells with 3 mu M vasopressin, or of hamster DDT1 MF-2 smooth muscle cells with 10 mu M bradykinin or 100 mu M histamine led within 4 h to a 40-50% down-regulation of the type 1 InsP(3) receptor
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::80d4532a9602b440b1b78514cf5bd547
https://doi.org/10.1016/s0143-4160(98)90070-7
https://doi.org/10.1016/s0143-4160(98)90070-7
Autor:
Humbert De Smedt, Rik Casteels, Ilse Sienaert, Sara Vanlingen, Jan B. Parys, Henk Sipma, Ludwig Missiaen
Publikováno v:
Europe PubMed Central
Inositol 1,4,5-trisphosphate (InsP3)-induced Ca2+ release from intracellular stores is generally assumed to be a ‘quantal’ process because low InsP3 concentrations mobilize less Ca2+ than high concentrations and a submaximal concentration does no
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3bf9af677ad48bc3d7190ea512fc81fd
https://doi.org/10.1042/bj3230123
https://doi.org/10.1042/bj3230123
Autor:
Rik Casteels, Sara Vanlingen, Ilse Sienaert, Jan B. Parys, Henk Sipma, Ludwig Missiaen, Humbert De Smedt
Publikováno v:
Journal of Biological Chemistry. 271:27005-27012
To study the Ca2+ regulation of the inositol 1,4,5-trisphosphate receptor (InsP3R) at the molecular level, we expressed various cytosolic and luminal regions of the mouse type I InsP3R as glutathione S-transferase fusion proteins. 45Ca2+ and rutheniu
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6e1575df7a5f4ed8a67693e0b20d4ccd
https://doi.org/10.1074/jbc.271.43.27005
https://doi.org/10.1074/jbc.271.43.27005
Publikováno v:
European Journal of Pharmacology. 305:207-212
The histamine H1 receptor mediated increase in cytoplasmic Ca2+ ([Ca2+]i) was measured in the presence of the known phospholipase C (PLC) inhibitor, neomycin. Neomycin (1 mM) inhibited the histamine (100 microM) induced rise in [Ca2+]i to the same ex
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::99a93226d808180155c2bc811cbca2e4
https://doi.org/10.1016/0014-2999(96)00167-7
https://doi.org/10.1016/0014-2999(96)00167-7
Publikováno v:
British Journal of Pharmacology, 115(6), 937-944. Wiley-Blackwell
1 Bradykinin caused a transient reduction of about 25% in the cyclic AMP level in forskolin prestimulated DDT1 MF-2 smooth muscle cells (IC50: 36.4 +/- 4.9 nM) and a pronounced, sustained inhibition (40%) of the isoprenaline-stimulated cyclic AMP lev
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d6d45a3ba498f51abbe3f74b5994cfe4
https://doi.org/10.1111/j.1476-5381.1995.tb15901.x
https://doi.org/10.1111/j.1476-5381.1995.tb15901.x
Publikováno v:
European journal of pharmacology-Molecular pharmacology section, 289(3), 463-469
Receptor-activated formation of inositol phosphates results in mobilization of intracellular stored Ca2+ in a variety of cells, including vas deferens derived DDT1 MF-2 cells. Stimulation of the histamine H-1 receptor on these cells caused a pronounc
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::56527bbfbff95d7c41b8469930782147
https://doi.org/10.1016/0922-4106(95)90155-8
https://doi.org/10.1016/0922-4106(95)90155-8