The Evaluation and Quantitation of Dihydrogen Metabolism Using Deuterium Isotope in Rats.

Autor: Radomir Hyspler, Alena Ticha, Henk Schierbeek, Alexander Galkin, Zdenek Zadak

Publikováno v: PLoS ONE, Vol 10, Iss 6, p e0130687 (2015)

Despite the significant interest in molecular hydrogen as an antioxidant in the last eight years, its quantitative metabolic parameters in vivo are still lacking, as is an appropriate method for determination of hydrogen effectivity in the mammalian

Externí odkaz: https://doaj.org/article/8d776c3e0e064a1f8d82d5ca8600d220

Development and validation of a gas chromatography–mass spectrometry method to analyze octanoate enrichments at low concentrations in human plasma

Autor: Suzan J. G. Knottnerus, Henk Schierbeek, Gepke Visser, Johannes B. van Goudoever, Dewi van Harskamp

Publikováno v: Analytical and Bioanalytical Chemistry
Analytical and bioanalytical chemistry, 412(23), 5789-5797. Springer Verlag

A new method for accurately analyzing octanoate enrichment in plasma was developed and validated. Samples were derivatized directly in plasma by transesterification with isobutanol and were analyzed by gas chromatography–mass spectrometry (GC-MS).

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2677f818f96e2fe78354a41c9d1375ba
http://www.scopus.com/inward/record.url?scp=85087675909&partnerID=8YFLogxK

Development and Validation of a New Gas Chromatography-Tandem Mass Spectrometry Method for the Measurement of Enrichment of Glyoxylate Metabolism Analytes in Hyperoxaluria Patients Using a Stable Isotope Procedure

Autor: Johannes B. van Goudoever, Henk Schierbeek, Jaap W. Groothoff, Michiel J. S. Oosterveld, Dewi van Harskamp, Sander F. Garrelfs

Publikováno v: Van Harskamp, D, Garrelfs, S F, Oosterveld, M J S, Groothoff, J W, Van Goudoever, J B & Schierbeek, H 2020, ' Development and Validation of a New Gas Chromatography-Tandem Mass Spectrometry Method for the Measurement of Enrichment of Glyoxylate Metabolism Analytes in Hyperoxaluria Patients Using a Stable Isotope Procedure ', Analytical Chemistry, vol. 92, no. 2, pp. 1826-1832 . https://doi.org/10.1021/acs.analchem.9b03670
Analytical Chemistry, 92(2), 1826-1832. American Chemical Society
Analytical chemistry, 92(2), 1826-1832. American Chemical Society
Analytical Chemistry

Primary hyperoxalurias (PH) are inborn errors of glyoxylate metabolism characterized by an increase in endogenous oxalate production. Oxalate overproduction may cause calcium-oxalate crystal formation leading to kidney stones, nephrocalcinosis, and u

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7818a97b177c79d5f2274739b41df9f2
http://www.scopus.com/inward/record.url?scp=85078397208&partnerID=8YFLogxK

In vivokinetic study of materno‐fetal fatty acid transfer in obese and normal weight pregnant women

Autor: Bram G. Sengers, Dewi van Harskamp, José E. Blanco-Carnero, Elvira Larqué, Henk Schierbeek, Johannes B. van Goudoever, Hans Demmelmair, Berthold Koletzko, Rohan M. Lewis, María T. Prieto-Sánchez, Simone Perazzolo, J. Efraim Oosterink, Antonio Gázquez

Publikováno v: J Physiol
Journal of Physiology, 597(19), 4959-4973. Wiley-Blackwell
Journal of physiology, 597(19), 4959-4973. Wiley-Blackwell

Key points: Placental structure and function can be modified as a result of maternal obesity affecting materno-fetal fatty acids (FA) transport. We report for the first time, in humans and in vivo, the kinetics of placental FA transfer in normo-weigh

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::01b1cacc4e5b7798de8ffdc74bd8a7f8
https://doi.org/10.1113/jp278146

ANGPTL3 Inhibition with Evinacumab Results in Faster Clearance of IDL and LDL apoB in Patients with Homozygous Familial Hypercholesterolemia - Brief Report

Autor: John S. Millar, Laurens F. Reeskamp, Hans Jansen, Geesje M. Dallinga-Thie, G. Kees Hovingh, Dewi van Harskamp, Henk Schierbeek, Liya Wu, Daniel J. Rader, Daniel A. Gipe, Marina Cuchel

Publikováno v: Arteriosclerosis, thrombosis, and vascular biology, 41(5), 1753-1759. Lippincott Williams and Wilkins
Arteriosclerosis, Thrombosis, and Vascular Biology

Supplemental Digital Content is available in the text.
Objective: The mechanism by which evinacumab, a fully human monoclonal antibody directed against ANGPTL3 (angiopoietin-like 3 protein) lowers plasma LDL (low-density lipoprotein) cholesterol

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ec4dc1aa039b5083495d1d137d28d579
https://pure.amc.nl/en/publications/angptl3-inhibition-with-evinacumab-results-in-faster-clearance-of-idl-and-ldl-apob-in-patients-with-homozygous-familial-hypercholesterolemia--brief-report(229b8efd-fcc3-485c-8d8f-449c0e5cbabd).html