Zobrazeno 1 - 10
of 171
pro vyhledávání: '"Henk P. Haagsman"'
Autor:
Nico van Os, Ali Javed, Femke Broere, Albert van Dijk, Melanie D. Balhuizen, Martin van Eijk, Suzan H.M. Rooijakkers, Bart W. Bardoel, Dani A.C. Heesterbeek, Henk P. Haagsman, Edwin Veldhuizen
Publikováno v:
Journal of Global Antimicrobial Resistance, Vol 30, Iss , Pp 406-413 (2022)
ABSTRACT: Objectives: Our group recently developed a new group of antimicrobial peptides termed PepBiotics, of which peptides CR-163 and CR-172 showed optimized antibacterial activity against Pseudomonas aeruginosa and Staphylococcus aureus without i
Externí odkaz:
https://doaj.org/article/4befd28c10f3431d952e270e4740cb56
Autor:
Roel M. van Harten, Johanna L.M. Tjeerdsma-van Bokhoven, Astrid de Greeff, Melanie D. Balhuizen, Albert van Dijk, Edwin J.A. Veldhuizen, Henk P. Haagsman, Maaike R. Scheenstra
Publikováno v:
Journal of Advanced Research, Vol 36, Iss , Pp 101-112 (2022)
Introduction: Due to the increase of antibiotic resistant bacterial strains, there is an urgent need for development of alternatives to antibiotics. Cathelicidins can be such an alternative to antibiotics having both a direct antimicrobial capacity a
Externí odkaz:
https://doaj.org/article/56f2c3a709914fcabbd62c5e4030ba46
Autor:
Ali Javed, Melanie D. Balhuizen, Arianne Pannekoek, Floris J. Bikker, Dani A. C. Heesterbeek, Henk P. Haagsman, Femke Broere, Markus Weingarth, Edwin J. A. Veldhuizen
Publikováno v:
Pharmaceuticals, Vol 16, Iss 10, p 1485 (2023)
The binding of Host Defense Peptides (HDPs) to the endotoxin of Gram-negative bacteria has important unsolved aspects. For most HDPs, it is unclear if binding is part of the antibacterial mechanism or whether LPS actually provides a protective layer
Externí odkaz:
https://doaj.org/article/4987097ab3a24735b6ab4d4bbe807274
Autor:
Jesús Pérez-Ortega, Roel M. Van Harten, Ria Van Boxtel, Michel Plisnier, Marc Louckx, Dominique Ingels, Henk P. Haagsman, Jan Tommassen
Publikováno v:
Virulence, Vol 12, Iss 1, Pp 1452-1468 (2021)
Whole-cell vaccines against Gram-negative bacteria commonly display high reactogenicity caused by the endotoxic activity of lipopolysaccharide (LPS), one of the major components of the bacterial outer membrane. Underacylation of the lipid A moiety of
Externí odkaz:
https://doaj.org/article/f279f887fb2d47fea4b021ea83261fa8
Autor:
Albert van Dijk, Jennifer Anten, Anne Bakker, Noah Evers, Anna T. Hoekstra, Jung-Chin Chang, Maaike R. Scheenstra, Edwin J. A. Veldhuizen, Mihai G. Netea, Celia R. Berkers, Henk P. Haagsman
Publikováno v:
Frontiers in Immunology, Vol 13 (2022)
Trained innate immunity can be induced in human macrophages by microbial ligands, but it is unknown if exposure to endogenous alarmins such as cathelicidins can have similar effects. Previously, we demonstrated sustained protection against infection
Externí odkaz:
https://doaj.org/article/d37d6ebc82eb4e7eac6d602f7bf731cf
Autor:
Lianci Peng, Maaike R. Scheenstra, Roel M. van Harten, Henk P. Haagsman, Edwin J. A. Veldhuizen
Publikováno v:
Veterinary Research, Vol 51, Iss 1, Pp 1-12 (2020)
Abstract Cathelicidins (CATHs) play an important role in the innate immune response against microbial infections. Among the four chicken cathelicidins, CATH-B1 is studied the least. In this study, the effect of CATH-B1 on the macrophage response towa
Externí odkaz:
https://doaj.org/article/6c0c19975e484945874af7b9015289ff
Autor:
Eline F. de Jonge, Melanie D. Balhuizen, Ria van Boxtel, Jianjun Wu, Henk P. Haagsman, Jan Tommassen
Publikováno v:
Current Research in Microbial Sciences, Vol 2, Iss , Pp 100009- (2021)
Pertussis, also known as whooping cough, is caused by the Gram-negative bacterium Bordetella pertussis, an obligate human pathogen. Despite high vaccination rates in high-income countries, resurgence of pertussis cases is an occurring problem that ur
Externí odkaz:
https://doaj.org/article/94b62ea94fb54ecf9b89971ab5bbd900
Autor:
Melanie D. Balhuizen, Chantal M. Versluis, Roel M. van Harten, Eline F. de Jonge, Jos F. Brouwers, Chris H.A. van de Lest, Edwin J.A. Veldhuizen, Jan Tommassen, Henk P. Haagsman
Publikováno v:
Current Research in Microbial Sciences, Vol 2, Iss , Pp 100010- (2021)
Host defense peptides (HDPs), such as cathelicidins, are small, cationic, amphipathic peptides and represent an important part of the innate immune system. Most cathelicidins, including the porcine PMAP-36, are membrane active and disrupt the bacteri
Externí odkaz:
https://doaj.org/article/50ce85dddf5846178b3ee968d0292b68
Autor:
Florent Le Guern, Anne Gaucher, Gina Cosentino, Marion Lagune, Henk P. Haagsman, Anne-Laure Roux, Damien Prim, Martin Rottman
Publikováno v:
International Journal of Molecular Sciences, Vol 23, Iss 24, p 16067 (2022)
Establishing the rapid and accurate diagnosis of sepsis is a key component to the improvement of clinical outcomes. The ability of analytical platforms to rapidly detect pathogen-associated molecular patterns (PAMP) in blood could provide a powerful
Externí odkaz:
https://doaj.org/article/77644fe0a83841b6959cd5187f6d91f7
Autor:
Melanie D. Balhuizen, Albert van Dijk, Jeroen W. A. Jansen, Chris H. A. van de Lest, Edwin J. A. Veldhuizen, Henk P. Haagsman
Publikováno v:
mSphere, Vol 6, Iss 4 (2021)
Antibiotic resistance is a pressing problem and estimated to be a leading cause of mortality by 2050. Antimicrobial peptides, also known as host defense peptides (HDPs), and HDP-derived antimicrobials have potent antimicrobial activity and high poten
Externí odkaz:
https://doaj.org/article/d3cc60f1c485413a823c3e5c82f8825d