Zobrazeno 1 - 10 of 126 pro vyhledávání: '"Henk Lingeman"'
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Derivatization in Liquid Chromatography: Introduction
Autor: Willy J. M. Underberg, Henk Lingeman
Chromatographic separation techniques such as high-performance liquid chromatography and gas chromatography (GC) in combination with selective and sensitive detection methods have gained an enormous popularity in the analysis of compounds of pharmace
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::2daaaee5ff792718253d15c4affcb565
https://doi.org/10.1201/9781003210153-1
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6
Comprehensive gas chromatography-electron ionisation mass spectrometric analysis of fatty acids and sterols using sequential one-pot silylation: quantification and isotopologue analysis
Autor: Dick-Paul Kloos, André M. Deelder, Franz Bracher, Martin Giera, Christoph Müller, Henk Lingeman, Oleg A. Mayboroda, Wilfried M. A. Niessen
Publikováno v: Rapid Communications in Mass Spectrometry. 28:1507-1514
RATIONALE Fatty acids and sterol lipids play crucial roles in several biological processes and several biological facts underline the interconnection between these lipid classes. Therefore, it is of interest to develop a comprehensive method analysin
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::2904464b92e3c337c3c851b53fda8c52
https://doi.org/10.1002/rcm.6923
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7
Evaluation of different column chemistries for fast urinary metabolic profiling
Autor: Martin Giera, Oleg A. Mayboroda, Dick-Paul Kloos, Wilfried M. A. Niessen, Henk Lingeman, André M. Deelder
Publikováno v: Kloos, D, Lingeman, H, Niessen, W M A, Deelder, A M, Giera, M & Mayboroda, O A 2013, ' Evaluation of different column chemistries for fast urinary metabolic profiling. ', Journal of Chromatography B, vol. 927, pp. 90-96 . https://doi.org/10.1016/j.jchromb.2013.02.017
Journal of Chromatography B, 927, 90-96
Journal of Chromatography B, 927, 90-96. Elsevier
Fast analytical methodologies are mandatory for large scale metabolic profiling. Here, we present a thorough evaluation of different column chemistries in combination with different mobile phases for fast LC-MS urinary metabolic profiling. Three poro
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2c8b7fe841b040ac06b7a07ee63d79ad
https://doi.org/10.1016/j.jchromb.2013.02.017
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8
Identification and quantification of drug-albumin adducts in serum samples from a drug exposure study in mice
Autor: Linda Switzar, Raymond Pieters, Wilfried M. A. Niessen, Henk Lingeman, Lydia M. Kwast, Martin Giera
Publikováno v: Switzar, L, Kwast, L M, Lingeman, H, Giera, M, Pieters, R H H & Niessen, W M A 2013, ' Identification and quantification of drug-albumin adducts in serum samples from a drug exposure study in mice ', Journal of Chromatography B, vol. 917-918, pp. 53-61 . https://doi.org/10.1016/j.jchromb.2012.12.033
Journal of Chromatography B, 917-918, 53-61. Elsevier
Journal of Chromatography B, 917, 53-61
The formation of drug-protein adducts following the bioactivation of drugs to reactive metabolites has been linked to adverse drug reactions (ADRs) and is a major complication in drug discovery and development. Identification and quantification of dr
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7d363d3dcfc2d104308ff508b123d477
https://hdl.handle.net/1871.1/6b6d8406-c285-4795-bcf6-aa7fcee51ae2
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9
An efficient analytical platform for on-line microfluidic profiling of neuroactive snake venoms towards nicotinic receptor affinity
Autor: Ben Bruyneel, Jeroen Kool, Freek J. Vonk, Henk Lingeman, Wilfried M. A. Niessen, Michael K. Richardson, August B. Smit, Reka A. Otvos, Ferry Heus
Publikováno v: Toxicon; Vol 61
Heus, F A H, Vonk, F, Otvos, R A, Bruyneel, B, Smit, A B, Lingeman, H, Richardson, M, Niessen, W M A & Kool, J 2013, ' An efficient analytical platform for on line microfluidic profiling of neurotoxic snake venoms towards nicotinic receptor like affinity. ', Toxicon, vol. 61, pp. 112-124 . https://doi.org/10.1016/j.toxicon.2012.11.002
Toxicon, 61, 112-124. Elsevier Limited
Venomous snakes have evolved their efficient venomous arsenals mainly to immobilize prey. The highly variable toxic peptides in these venoms target a myriad of neurotoxic and haemotoxic receptors and enzymes and comprise highly interesting candidates
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a9dd34e3a5cc3a16c6704c2533a5cad5
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10
Derivatization of the tricarboxylic acid cycle intermediates and analysis by online solid-phase extraction–liquid chromatography–mass spectrometry with positive-ion electrospray ionization
Autor: D. Kloos, Henk Lingeman, Oleg A. Mayboroda, Wilfried M. A. Niessen, Rico J. E. Derks, Martin Giera, Maikel Wijtmans, André M. Deelder
Publikováno v: Kloos, D, Derks, R J E, Wijtmans, M, Lingeman, H, Mayboroda, O A, Deelder, A M, Niessen, W M A & Giera, M 2012, ' Derivatization of the tricarboxylic acid cycle intermediates and analysis by online solid-phase extraction–liquid chromatography–mass spectrometry with positive-ion electrospray ionization ', Journal of Chromatography A, vol. 1232, pp. 19-26 . https://doi.org/10.1016/j.chroma.2011.07.095
Journal of Chromatography A, 1232, 19-26
Journal of Chromatography A, 1232, 19-26. Elsevier
The analysis of cellular metabolic processes is of fundamental biological interest. Cellular metabolites, such as the intermediates of the tricarboxylic acid (TCA) cycle, provide essential information about the metabolic state of the cell. Not only i
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a7610c6ccff51d770dc26fa8aaf594f3
https://doi.org/10.1016/j.chroma.2011.07.095
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