Zobrazeno 1 - 10
of 13
pro vyhledávání: '"Henk C. Trap"'
Autor:
Hendrik P. Benschop, John P. Oostdijk, Henk C. Trap, Herman P.M. van Helden, Willem C. Kuijpers, Jan P. Langenberg
Publikováno v:
Journal of Applied Toxicology. 24:59-68
The purpose of this pilot study was to indicate, for low-level exposure of conscious guinea pigs and marmoset monkeys to sarin vapour in air, the lowest-observable-adverse-effect level (LOAEL) of sarin for miosis. This is the concentration × time (C
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1c02198647d85b2b7e9c3ffadda76549
https://doi.org/10.1002/jat.948
https://doi.org/10.1002/jat.948
Autor:
Jan P. Langenberg, Henk C. Trap
Publikováno v:
Journal of High Resolution Chromatography. 22:153-158
A method is presented for the continuous analysis of generated vapors of the nerve agents soman and satin and the blistering agent sulfur mustard. By using a gas sampling valve and a very short (15 cm) column connected to an on-column injector with a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::5c6cbcd2864d28ad30851543c4158df5
https://doi.org/10.1002/(sici)1521-4168(19990301)22:3<153::aid-jhrc153>3.0.co
https://doi.org/10.1002/(sici)1521-4168(19990301)22:3<153::aid-jhrc153>3.0.co
Autor:
Helma E.T. Spruit, Jan P. Langenberg, Hendrik P. Benschop, H.J. van der Wiel, L.P.A. de Jong, Henk C. Trap
Publikováno v:
Toxicology and Applied Pharmacology. 153:179-185
In order to initiate a quantitative basis for the toxicology of low level exposure to nerve agents, the toxicokinetics of soman stereoisomers during nose-only exposure for 5 h to 20 ppb (160 microg/m3) of C(+/-)P(+/-)-soman in air were studied in res
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::63d72fb50ee08dbf845765b46a9aea80
https://doi.org/10.1006/taap.1998.8490
https://doi.org/10.1006/taap.1998.8490
Publikováno v:
Archives of Toxicology. 71:171-178
As part of a program to develop methods for the verification of alleged exposure to sulphur mustard, we synthesized and characterized three amino acid adducts presumably formed by alkylation of haemoglobin: 4-(2-hydroxyethylthioethyl)-l-aspartate, 5-
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9c68f9dfb9143d23de2a95311efe7cd4
https://doi.org/10.1007/s002040050372
https://doi.org/10.1007/s002040050372
Publikováno v:
Archives of Toxicology. 67:706-711
Pretreatment of rats and guinea pigs with the specific carboxylesterase inhibitor 2-(o-cresyl)-4H-1 ∶ 3 ∶ 2-benzodioxaphosphorin-2-oxide (CBDP) reduces the LD50 of the nerve agent C(±)P(±)-soman in these species to the same range as in primates
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b1f4d259e154af75292840ba12c58c27
https://doi.org/10.1007/bf01973695
https://doi.org/10.1007/bf01973695
Autor:
L.P.A. de Jong, Hendrik P. Benschop, Anne H. Due, Henk C. Trap, C. Van Dijk, H. P. M. Van Helden, H.J. van der Wiel
Publikováno v:
Life Sciences. 50:1057-1062
Concentrations of C(+/-)P(+/-)-soman (1,2,2-trimethylpropyl methylphosphonofluoridate) in urine of anaesthetized, atropinized and artificially ventilated rats, guinea pigs and marmosets were determined 1-4 h after iv administration of 1-6 LD50 of the
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e3fa0ecc054749f3975e0baddce7a00b
https://doi.org/10.1016/0024-3205(92)90101-t
https://doi.org/10.1016/0024-3205(92)90101-t
Autor:
Arvind Visvanathan, John P. Oostdijk, Mingtian Ni, Stephen E. Reichenbach, Edward B. Ledford, Visweswara Kottapalli, Henk C. Trap
Publikováno v:
SPIE Proceedings.
Comprehensive two-dimensional gas chromatography (GCxGC) is an emerging technology for chemical separation that provides an order-of-magnitude increase in separation capacity over traditional gas chromatography. GCxGC separates chemical species with
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::a1e2d8faec7bb9278dd4bef042012fb3
https://doi.org/10.1117/12.497346
https://doi.org/10.1117/12.497346
Autor:
Hendrik P. Benschop, Willem C. Kuijpers, Herman P.M. van Helden, Jan P. Langenberg, John P. Oostdijk, Henk C. Trap
Publikováno v:
Toxicology and applied pharmacology. 189(3)
Realistic scenarios for low-level exposure to nerve agents will often involve exposures over several hours to extremely low doses of agent. In order to expose animals to the lowest controllable concentrations of agent and to increase exposure times u
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8e5f10a9cb23ef8cf908db47ed9a9fbb
https://pubmed.ncbi.nlm.nih.gov/12791302
https://pubmed.ncbi.nlm.nih.gov/12791302
Autor:
Rob B. Helmich, Herma J. van der Wiel, Hendrik P. Benschop, Jan P. Langenberg, Herman P.M. van Helden, Helma E.T. Spruit, Henk C. Trap
Publikováno v:
Toxicology and applied pharmacology. 169(3)
We report the first toxicokinetic studies of (±)-sarin. The toxicokinetics of the stereoisomers of this nerve agent were studied in anesthetized, atropinized, and restrained guinea pigs after intravenous bolus administration of a dose corresponding
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0325916c6c6a8cc2151a38a2b4900786
https://pubmed.ncbi.nlm.nih.gov/11133347
https://pubmed.ncbi.nlm.nih.gov/11133347
Autor:
Jan P. Langenberg, G.P. van der Schans, Roos H. Mars-Groenendijk, H. C. M. Van Dijk-Knijnenburg, Hendrik P. Benschop, Willem C. Kuijpers, Henk C. Trap, H.P.M. van Helden, Helma E.T. Spruit
Publikováno v:
Drug and chemical toxicology. 21
In order to provide a quantitative basis for pretreatment and therapy of intoxications with sulfur mustard (SM) the toxicokinetics of this agent as well as its major DNA-adduct were studied in male hairless guinea pigs for the intravenous, respirator
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3a7a00d09f7f84f0b3fe8881c6eb4589
https://pubmed.ncbi.nlm.nih.gov/10028407
https://pubmed.ncbi.nlm.nih.gov/10028407