Zobrazeno 1 - 10
of 239
pro vyhledávání: '"Henk C. Hoogsteden"'
Autor:
Henk C. Hoogsteden, Joost P.J.J. Hegmans, Rudi W. Hendriks, Arnold G. Vulto, Bronno van der Holt, Eric Braakman, Cynthia Waasdorp, Ferry A.L.M. Eskens, André Kunert, Niken M. Mahaweni, Cor H. van der Leest, Koen Bezemer, Margaretha E.H. Kaijen-Lambers, Robin Cornelissen, Pauline L. de Goeje, Joachim G.J.V. Aerts
Purpose: Mesothelioma has been regarded as a nonimmunogenic tumor, which is also shown by the low response rates to treatments targeting the PD-1/PD-L1 axis. Previously, we demonstrated that autologous tumor lysate–pulsed dendritic cell (DC) immuno
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::47c01604ce053715c2dca9b66ef0a9ab
https://doi.org/10.1158/1078-0432.c.6525983.v1
https://doi.org/10.1158/1078-0432.c.6525983.v1
Autor:
Henk C. Hoogsteden, Joost P.J.J. Hegmans, Rudi W. Hendriks, Arnold G. Vulto, Bronno van der Holt, Eric Braakman, Cynthia Waasdorp, Ferry A.L.M. Eskens, André Kunert, Niken M. Mahaweni, Cor H. van der Leest, Koen Bezemer, Margaretha E.H. Kaijen-Lambers, Robin Cornelissen, Pauline L. de Goeje, Joachim G.J.V. Aerts
Supplementary Material and Methods: Preparation of allogeneic tumor lysate Figure S1: CD8 T-cells from DC immunotherapy treated mice show tumor cell killing capacity Figure S2: Progression free survival of patients in the first-in-human clinical stud
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0f97b6c8e3225f046d755e41fbb18e34
https://doi.org/10.1158/1078-0432.22465283.v1
https://doi.org/10.1158/1078-0432.22465283.v1
Autor:
Lisanne Noordam, Margaretha E.H. Kaijen, Koen Bezemer, Robin Cornelissen, Lex A.P.W.M. Maat, Henk C. Hoogsteden, Joachim G.J.V. Aerts, Rudi W. Hendriks, Joost P.J.J Hegmans, Heleen Vroman
Publikováno v:
OncoImmunology, Vol 7, Iss 12 (2018)
Rationale: Regulatory T cells (Treg) play a pivotal role in the immunosuppressive tumor micro-environment in cancer, including mesothelioma. Recently, the combination of autologous tumor lysate-pulsed dendritic cells (DC) and metronomic cyclophospham
Externí odkaz:
https://doaj.org/article/5511702cf6784ad3925ba874ceb4f0f3
Autor:
Mirjam J.G. van Manen, Michael Kreuter, Bernt van den Blink, Ute Oltmanns, Karin Palmowski, Eva Brunnemer, Simone Hummler, Nelleke C. Tak, Leon van den Toorn, Jelle Miedema, Henk C. Hoogsteden, Marlies S. Wijsenbeek
Publikováno v:
ERJ Open Research, Vol 3, Iss 1 (2017)
Pulmonary fibrosis greatly impacts patients and their partners. Unmet needs of patients are increasingly acknowledged; the needs of partners often remain unnoticed. Little is known about the best way to educate patients and partners. We investigated
Externí odkaz:
https://doaj.org/article/2f4841c5809741588199cc533130ff3d
Autor:
Sue McKay, Mechteld M. Grootte Bromhaar, Johan C. de Jongste, Henk C. Hoogsteden, Pramod R. Saxena, Hari S. Sharma
Publikováno v:
Mediators of Inflammation, Vol 10, Iss 3, Pp 135-142 (2001)
Background: Airway smooth muscle (ASM) is considered to be a target for mediators released during airway inflammation.
Externí odkaz:
https://doaj.org/article/e7bd38c01c84498f8e461ccc058d537f
Publikováno v:
Mediators of Inflammation, Vol 10, Iss 1, Pp 21-26 (2001)
Background: In smoking COPD patients the bronchoalveolar lavage (BAL) fluid contains high numbers of inflammatory cells. These cells might produce arachidonic acid (AA) metabolites, which contribute to inflammation and an increased bronchomotor tone.
Externí odkaz:
https://doaj.org/article/01f69c12b0234c628a1065febae27d7c
Autor:
Gert T. Verhoeven, Annemarie J.M. Wijkhuijs, Herbert Hooijkaas, Henk C. Hoogsteden, Wim Sluiter
Publikováno v:
Mediators of Inflammation, Vol 9, Iss 2, Pp 109-113 (2000)
Oxidative stress in the lung is important in the pathogenesis of COPD. Published data indicate that glucocorticoids inhibit blood cells in their capacity to produce reactive oxygen species (ROS). We investigated the effect of Fluticasone propionate (
Externí odkaz:
https://doaj.org/article/920d7cd9d0394453b53cc5af8f349034
Autor:
Ingrid M. Garrelds, Peter Th. W. Van Hal, Raquel C. Haakmat, Henk C. Hoogsteden, Pramod R. Saxena, Frederik J. Zijlstra
Publikováno v:
Mediators of Inflammation, Vol 8, Iss 4-5, Pp 229-235 (1999)
In the present study the human monoblast cell line U937 has been used as a model to study the function of human mononuclear phagocytes in asthma. The kinetics of the production of eicosanoids and cytokines, which are thought to play a role in the pat
Externí odkaz:
https://doaj.org/article/b9dbe9df8efd42379e6c22aaa733ae07
Autor:
Dominique de Costa, Ingrid Broodman, Wim Calame, Christoph Stingl, Lennard J M Dekker, René M Vernhout, Harry J de Koning, Henk C Hoogsteden, Peter A E Sillevis Smitt, Rob J van Klaveren, Theo M Luider, Martijn M Vanduijn
Publikováno v:
PLoS ONE, Vol 9, Iss 5, p e96029 (2014)
Late diagnosis of lung cancer is still the main reason for high mortality rates in lung cancer. Lung cancer is a heterogeneous disease which induces an immune response to different tumor antigens. Several methods for searching autoantibodies have bee
Externí odkaz:
https://doaj.org/article/c8899289cfd94da383c5aa6189c2c894
Autor:
Robin Cornelissen, Lysanne A Lievense, Alexander P Maat, Rudi W Hendriks, Henk C Hoogsteden, Ad J Bogers, Joost P Hegmans, Joachim G Aerts
Publikováno v:
PLoS ONE, Vol 9, Iss 9, p e106742 (2014)
HYPOTHESIS:The tumor micro-environment and especially the different macrophage phenotypes appear to be of great influence on the behavior of multiple tumor types. M1 skewed macrophages possess anti-tumoral capacities, while the M2 polarized macrophag
Externí odkaz:
https://doaj.org/article/d7d0771c3a6045d8b20ab051199dda4e