Zobrazeno 1 - 10
of 41
pro vyhledávání: '"Henk‐Jan Westeneng"'
Autor:
Astrid T. van der Geest, Channa E. Jakobs, Tijana Ljubikj, Christiaan F. M. Huffels, Marta Cañizares Luna, Renata Vieira de Sá, Youri Adolfs, Marina de Wit, Daan H. Rutten, Marthe Kaal, Maria M. Zwartkruis, Mireia Carcolé, Ewout J. N. Groen, Elly M. Hol, Onur Basak, Adrian M. Isaacs, Henk-Jan Westeneng, Leonard H. van den Berg, Jan H. Veldink, Domino K. Schlegel, R. Jeroen Pasterkamp
Publikováno v:
Acta Neuropathologica Communications, Vol 12, Iss 1, Pp 1-31 (2024)
Abstract A hexanucleotide repeat expansion (HRE) in C9ORF72 is the most common genetic cause of amyotrophic lateral sclerosis (ALS) and frontotemporal dementia (FTD). Human brain imaging and experimental studies indicate early changes in brain struct
Externí odkaz:
https://doaj.org/article/081ca424a8b945aa9f02a6c9589c4317
Autor:
Renata Vieira de Sá, Emma Sudria-Lopez, Marta Cañizares Luna, Oliver Harschnitz, Dianne M. A. van den Heuvel, Sandra Kling, Danielle Vonk, Henk-Jan Westeneng, Henk Karst, Lauri Bloemenkamp, Suzy Varderidou-Minasian, Domino K. Schlegel, Mayte Mars, Mark H. Broekhoven, Nicky C. H. van Kronenburg, Youri Adolfs, Vamshidhar R. Vangoor, Rianne de Jongh, Tijana Ljubikj, Lianne Peeters, Sabine Seeler, Enric Mocholi, Onur Basak, David Gordon, Fabrizio Giuliani, Tessa Verhoeff, Giel Korsten, Teresa Calafat Pla, Morten T. Venø, Jørgen Kjems, Kevin Talbot, Michael A. van Es, Jan H. Veldink, Leonard H. van den Berg, Pavol Zelina, R. Jeroen Pasterkamp
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-25 (2024)
Abstract Intermediate-length repeat expansions in ATAXIN-2 (ATXN2) are the strongest genetic risk factor for amyotrophic lateral sclerosis (ALS). At the molecular level, ATXN2 intermediate expansions enhance TDP-43 toxicity and pathology. However, wh
Externí odkaz:
https://doaj.org/article/f542924285bc411ab2ef82b8bba3d188
Autor:
Remko M. van Eenennaam, Willeke J. Kruithof, Michael A. van Es, Esther T. Kruitwagen-van Reenen, Henk-Jan Westeneng, Johanna M. A. Visser-Meily, Leonard H. van den Berg, Anita Beelen
Publikováno v:
BMC Neurology, Vol 20, Iss 1, Pp 1-11 (2020)
Abstract Background Personalized ENCALS survival prediction model reliably estimates the personalized prognosis of patients with amyotrophic lateral sclerosis. Concerns were raised on discussing personalized prognosis without causing anxiety and dest
Externí odkaz:
https://doaj.org/article/1b1bbf4f401640a3b5fe6ac91f67b75c
Autor:
Marloes Stam, Renske I. Wadman, Bart Bartels, Maureen Leeuw, Henk-Jan Westeneng, Camiel A. Wijngaarde, Leonard H. van den Berg, W. Ludo van der Pol
Publikováno v:
Orphanet Journal of Rare Diseases, Vol 13, Iss 1, Pp 1-7 (2018)
Abstract Background To determine the value of a continuous repetitive task to detect and quantify fatigability as additional dimension of impaired motor function in patients with hereditary proximal spinal muscular atrophy (SMA). Results In this repe
Externí odkaz:
https://doaj.org/article/b3f9850b90184cc084fb13cdfa461df4
Autor:
Hannelore K. van der Burgh, Ruben Schmidt, Henk-Jan Westeneng, Marcel A. de Reus, Leonard H. van den Berg, Martijn P. van den Heuvel
Publikováno v:
NeuroImage: Clinical, Vol 13, Iss C, Pp 361-369 (2017)
Amyotrophic lateral sclerosis (ALS) is a progressive neuromuscular disease, with large variation in survival between patients. Currently, it remains rather difficult to predict survival based on clinical parameters alone. Here, we set out to use clin
Externí odkaz:
https://doaj.org/article/914548be30a7449da49ede61b553ef28
Autor:
Hannelore K. van der Burgh, Henk-Jan Westeneng, Jil M. Meier, Michael A. van Es, Jan H. Veldink, Jeroen Hendrikse, Martijn P. van den Heuvel, Leonard H. van den Berg
Publikováno v:
NeuroImage: Clinical, Vol 24, Iss , Pp - (2019)
Background: Amyotrophic lateral sclerosis (ALS) is a progressive neuromuscular disease characterized by both upper and lower motor neuron degeneration. While neuroimaging studies of the brain can detect upper motor neuron degeneration, these brain MR
Externí odkaz:
https://doaj.org/article/401336cc3e5a4e0a9a38a7529cb54a47
Autor:
Wouter van Rheenen, Frank P Diekstra, Oliver Harschnitz, Henk-Jan Westeneng, Kristel R van Eijk, Christiaan G J Saris, Ewout J N Groen, Michael A van Es, Hylke M Blauw, Paul W J van Vught, Jan H Veldink, Leonard H van den Berg
Publikováno v:
PLoS ONE, Vol 13, Iss 6, p e0198874 (2018)
The biological pathways involved in amyotrophic lateral sclerosis (ALS) remain elusive and diagnostic decision-making can be challenging. Gene expression studies are valuable in overcoming such challenges since they can shed light on differentially r
Externí odkaz:
https://doaj.org/article/b3e99309fc2a4f96ac6fbd36980e6fab
Autor:
Michael A van Es, Harold H G Tan, Jeroen Hendrikse, Abram D Nitert, Renée Walhout, Henk-Jan Westeneng, Leonard H. van den Berg, Nienke L Knijnenburg, Jan H. Veldink
Publikováno v:
Journal of Neurology, Neurosurgery, and Psychiatry
ObjectivesTo investigate sensitivity of brain MRI and neurological examination for detection of upper motor neuron (UMN) degeneration in patients with amyotrophic lateral sclerosis (ALS).MethodsWe studied 192 patients with ALS and 314 controls longit
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::412506bc826ecbb4ce6be96c8f2af258
https://doi.org/10.1136/jnnp-2021-327269
https://doi.org/10.1136/jnnp-2021-327269
Autor:
Kevin van Veenhuijzen, Henk‐Jan Westeneng, Harold H. G. Tan, Abram D. Nitert, Hannelore K. van der Burgh, Isabel Gosselt, Michael A. van Es, Tanja C. W. Nijboer, Jan H. Veldink, Leonard H. van den Berg
Publikováno v:
Annals of neurologyReferences.
We investigated effects of C9orf72 repeat expansion and gene expression on longitudinal cerebral changes before symptom onset.We enrolled 79 asymptomatic family members (AFMs) from 9 families with C9orf72 repeat expansion. Twenty-eight AFMs carried t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::204fd6eae02a329c2a32530dfb285716
https://pubmed.ncbi.nlm.nih.gov/36511398
https://pubmed.ncbi.nlm.nih.gov/36511398
Autor:
Harold H. G. Tan, Henk‐Jan Westeneng, Abram D. Nitert, Kevin van Veenhuijzen, Jil M. Meier, Hannelore K. van der Burgh, Martine J. E. van Zandvoort, Michael A. van Es, Jan H. Veldink, Leonard H. van den Berg
Publikováno v:
Annals of neurologyReferences. 92(6)
The purpose of this study was to identify subtypes of amyotrophic lateral sclerosis (ALS) by comparing patterns of neurodegeneration using brain magnetic resonance imaging (MRI) and explore their phenotypes.We performed T1-weighted and diffusion tens
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::010df0eadfbb701a64c1b76bc53c60df
https://pubmed.ncbi.nlm.nih.gov/36054734
https://pubmed.ncbi.nlm.nih.gov/36054734