Výsledky vyhledávání - "Henk, Regeling"

The chemistry of D-gluconic acid derivatives. Part 1: Synthesis of 3,4;5,6-di-O-isopropylidene-D-glucitol and 2,3;4,5-di-O-isopropylidene-aldehydo-D-arabinose from D-glucono-1,5-lactone

Autor: Henk Regeling, Egbert de Rouville, Gordon J. F. Chittenden

Publikováno v: Recueil des Travaux Chimiques des Pays-Bas. 106:461-464

Acid-catalysed isopropylidenation of D-glucono-1,5-lactone with 2,2-dimethoxypropane yields methyl 3,4;5,6-di-O-isopropylidene-D-gluconate. Convenient syntheses of the title compounds from this ester by reduction and oxidation sequences, together wit

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::d83bc84f7215385705ed0b8a09cc1481
https://doi.org/10.1002/recl.19871060805

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Syntheses of Pantolactone and Pantothenic Acid Derivatives as Potential Lipid Regulating Agents

Autor: Lianhao Zhang, Ralf Mueller, Michael E. Pape, Andrew McKee, Eelco J. Ebbers, Charles L. Bisgaier, Bruce H. McCosar, Jean-Louis H Dasseux, Clay T. Cramer, Dennis Smith, Mike Relou, Henk Regeling, Emil Pop, B.R. Krause, Frank M. C. Leemhuis, Roel P.L. Bell, Dennis Verdijk, Brian Goetz, Daniela Carmen Oniciu

Publikováno v: Synthetic Communications. 36:365-391

A series of pantolactone and pantothenic acid derivatives (1–10) were synthesized to be tested for their potential as lipid regulating agents that act as Coenzyme‐A mimics. The syntheses were performed with moderate to high yields.

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::f53ca7faef49ee107a23924ef932d1f1
https://doi.org/10.1080/00397910500377545

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α-cycloalkyl-substituted ω-keto-dicarboxylic acids as lipid regulating agents

Autor: Roel P L, Bell, Dennis, Verdijk, Mike, Relou, Dennis, Smith, Henk, Regeling, Eelco J, Ebbers, Frank M C, Leemhuis, Daniela C, Oniciu, Clay T, Cramer, Brian, Goetz, Michael E, Pape, Brian R, Krause, Charles L, Bisgaier, Jean-Louis, Dasseux

Publikováno v: Bioorganic & Medicinal Chemistry. 13:223-236

A series of cycloalkyl-substituted oxo-alkanedicarboxylic acids have been prepared by the TosMIC methodology departing from haloalkyl-substituted cycloalkylcarboxylic esters. cyclopropyl derivatives showed IC50 activity in the 0.3–1.0 μM range on

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::78510470ed7f346fd296d9349082a003
https://doi.org/10.1016/j.bmc.2004.09.046

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Synthesis of 1-deoxy-l-gulonojirimycin (l-guloDNJ) and 1-deoxy-d-talonojirimycin (d-taloDNJ)

Autor: Henk Regeling, Gordon J. F. Chittenden, Binne Zwanenburg, Cosam C. Joseph

Publikováno v: Carbohydrate Research. 337:1083-1087

Carbohydrate based syntheses of azasugars with unusual configurations viz. 1,5-dideoxy-1,5-imino- l -gulitol ( l -guloDNJ) and 1,5-dideoxy-1,5-imino- l -talitol ( l -taloDNJ) are reported, from d -mannose and d -fructose, respectively. The key steps

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9b127bb8b93158153609037b582d877d
https://doi.org/10.1016/s0008-6215(02)00100-3

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Decyl and dodecyl β-d-fructofuranosides

Autor: Binne Zwanenburg, Gordon J. F. Chittenden, Henk Regeling

Publikováno v: Carbohydrate Research. 314:267-272

Decyl and dodecyl β- d -fructofuranosides are formed from d -fructose and catalysed by boron trifluoride alcoholates, in admixture with the corresponding α- d anomers and β- d -pyranosides. These were separated by chromatography and each of the pr

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::a4ac70e331a2d4a2e1b893e4cfcfa087
https://doi.org/10.1016/s0008-6215(98)00308-5

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Synthesis and reactions of some derivatives of (3,6S,9R,10R,11S)-1,4,7-trioxaspiro[5,5]undecane-3,9,10,11-tetrol: novel quasi-saccharides1Presented at the 2nd International Meeting of the Portuguese Carbohydrate Chemistry Group, Porto, Portugal, 21–25 September 1997.1

Autor: Gordon J. F. Chittenden, Henk Regeling, René de Gelder, Fortunatus Sung’hwa, Binne Zwanenburg

Publikováno v: Carbohydrate Polymers. 37:323-333

The title compound was obtained by reductive ozonolysis of allyl β- d -fructopyranoside. The synthesis and characterization of a number of C-3-substituted derivatives using conventional carbohydrate procedures is described. Some of the products may

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::546eefdf15c51d98c515c204743569c4
https://doi.org/10.1016/s0144-8617(98)00078-2

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Enantiospecific syntheses of (R)- and (S)-proline and some derivatives from D-glucono-1,5-lactone

Autor: Gordon J. F. Chittenden, Henk Regeling, Binne Zwanenburg, Claudio Mazzini, Letitia Sambri

Publikováno v: Journal of the Chemical Society-Perkin Transactions 1, 3351-3356. Royal soc chemistry
STARTPAGE=3351;ENDPAGE=3356;ISSN=0300-922X;TITLE=Journal of the Chemical Society-Perkin Transactions 1
Journal of the Chemical Society-Perkin Transactions 1, 22, pp. 3351-3356

Carbohydrate-based enantiospecific syntheses of (R)-proline 1 and (S)-proline 2 from the previously reported D-erythro-hexonate ester 9 are described. Azide-substitution reactions on appropriately activated intermediates derived from ester 9, followe

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https://hdl.handle.net/2066/27779

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