Zobrazeno 1 - 10
of 80
pro vyhledávání: '"Henk, Karst"'
Autor:
Renata Vieira de Sá, Emma Sudria-Lopez, Marta Cañizares Luna, Oliver Harschnitz, Dianne M. A. van den Heuvel, Sandra Kling, Danielle Vonk, Henk-Jan Westeneng, Henk Karst, Lauri Bloemenkamp, Suzy Varderidou-Minasian, Domino K. Schlegel, Mayte Mars, Mark H. Broekhoven, Nicky C. H. van Kronenburg, Youri Adolfs, Vamshidhar R. Vangoor, Rianne de Jongh, Tijana Ljubikj, Lianne Peeters, Sabine Seeler, Enric Mocholi, Onur Basak, David Gordon, Fabrizio Giuliani, Tessa Verhoeff, Giel Korsten, Teresa Calafat Pla, Morten T. Venø, Jørgen Kjems, Kevin Talbot, Michael A. van Es, Jan H. Veldink, Leonard H. van den Berg, Pavol Zelina, R. Jeroen Pasterkamp
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-25 (2024)
Abstract Intermediate-length repeat expansions in ATAXIN-2 (ATXN2) are the strongest genetic risk factor for amyotrophic lateral sclerosis (ALS). At the molecular level, ATXN2 intermediate expansions enhance TDP-43 toxicity and pathology. However, wh
Externí odkaz:
https://doaj.org/article/f542924285bc411ab2ef82b8bba3d188
Autor:
Suzy Varderidou-Minasian, Bert M. Verheijen, Oliver Harschnitz, Sandra Kling, Henk Karst, W. Ludo van der Pol, R. Jeroen Pasterkamp, Maarten Altelaar
Publikováno v:
ACS Omega, Vol 6, Iss 51, Pp 35375-35388 (2021)
Externí odkaz:
https://doaj.org/article/e82a0a9c2a524d3fa27fb3e05b82551b
Autor:
Paul R. Ormel, Renata Vieira de Sá, Emma J. van Bodegraven, Henk Karst, Oliver Harschnitz, Marjolein A. M. Sneeboer, Lill Eva Johansen, Roland E. van Dijk, Nicky Scheefhals, Amber Berdenis van Berlekom, Eduardo Ribes Martínez, Sandra Kling, Harold D. MacGillavry, Leonard H. van den Berg, René S. Kahn, Elly M. Hol, Lot D. de Witte, R. Jeroen Pasterkamp
Publikováno v:
Nature Communications, Vol 9, Iss 1, Pp 1-14 (2018)
Brain organoid models reported to date lack cells of mesodermal origin, such as microglia. Here, the authors demonstrate that mature microglia-like cells are generated within their cerebral organoid model, providing new avenues for studying human mic
Externí odkaz:
https://doaj.org/article/0f43c1e80fff44ada197169a4b75a7dc
Autor:
Christiaan F M, Huffels, Roland E, van Dijk, Henk, Karst, Frank J, Meye, Elly M, Hol, Jinte, Middeldorp
Publikováno v:
Journal of Alzheimer's Disease. 89:283-297
Background: Aging is characterized by systemic alterations and forms an important risk factor for Alzheimer’s disease (AD). Recently, it has been indicated that blood-borne factors present in the systemic milieu contribute to the aging process. Exp
Autor:
Henk Karst, Wouter J. Droogers, Nelleke van der Weerd, Ruth Damsteegt, Nicky van Kronenburg, R. Angela Sarabdjitsingh, Marian Joëls
Publikováno v:
Neuropharmacology. 234:109543
Autor:
Sofia Kanatsou, Henk Karst, Despoina Kortesidou, Rachelle A. van den Akker, Jan den Blaauwen, Anjanette P. Harris, Jonathan R. Seckl, Harm J. Krugers, Marian Joels
Publikováno v:
Frontiers in Cellular Neuroscience, Vol 11 (2017)
Evidence from human studies suggests that high expression of brain mineralocorticoid receptors (MR) may promote resilience against negative consequences of stress exposure, including childhood trauma. We examined, in mice, whether brain MR overexpres
Externí odkaz:
https://doaj.org/article/1d39ba41bc8e4ef595882a0c6fdb6e2e
Autor:
R Angela Sarabdjitsingh, Natasha Pasricha, Johanna A S Smeets, Amber Kerkhofs, Lenka Mikasova, Henk Karst, Laurent Groc, Marian Joëls
Publikováno v:
PLoS ONE, Vol 11, Iss 1, p e0145858 (2016)
In recent years it has become clear that corticosteroid hormones (such as corticosterone) are released in ultradian pulses as a natural consequence of pituitary-adrenal interactions. All organs, including the brain, are thus exposed to pulsatile chan
Externí odkaz:
https://doaj.org/article/c31da707038e42d78b234dbec98292f3
Autor:
Nelleke van der Weerd, Henk Karst, R. Angela Sarabdjitsingh, Ruth Damsteegt, Marian Joëls, Eline Feenstra
Publikováno v:
Neuropharmacology, 180:108294, 1-12. PERGAMON-ELSEVIER SCIENCE LTD
In this study we tested the hypothesis i) that age-dependent shifts in the excitation-inhibition balance of pre-frontal neurons are accelerated by early life stress, a risk factor for the etiology of many psychiatric disorders; and if so, ii) that th
Publikováno v:
PLoS ONE, Vol 7, Iss 8, p e42143 (2012)
BACKGROUND: Glucocorticoid hormones, in interaction with noradrenaline, enable the consolidation of emotionally arousing and stressful experiences in rodents and humans. Such interaction is thought to occur at least partly in the basolateral nucleus
Externí odkaz:
https://doaj.org/article/5ab81e392db941fe8f4236a3c9f7b463
Publikováno v:
Frontiers in Synaptic Neuroscience, Vol 2 (2010)
Exposure of an organism to environmental challenges activates two hormonal systems that help the organism to adapt. As part of this adaptational process, brain processes are changed such that appropriate behavioral strategies are selected that allow
Externí odkaz:
https://doaj.org/article/a180c32a2a364a3b9d226929bfecad65