Zobrazeno 1 - 10
of 286
pro vyhledávání: '"Hening LIn"'
Publikováno v:
ACS Central Science, Vol 10, Iss 10, Pp 1835-1847 (2024)
Externí odkaz:
https://doaj.org/article/0319e02cb5d047718fc96739c34ca2af
Autor:
Tao Yu, Dan Hou, Jiaqi Zhao, Xuan Lu, Wendy K. Greentree, Qian Zhao, Min Yang, Don-Gerard Conde, Maurine E. Linder, Hening Lin
Publikováno v:
Cell Reports, Vol 43, Iss 4, Pp 114070- (2024)
Summary: Nucleotide oligomerization domain (NOD)-like receptor protein 3 (NLRP3) inflammasome hyperactivation contributes to many human chronic inflammatory diseases, and understanding how NLRP3 inflammasome is regulated can provide strategies to tre
Externí odkaz:
https://doaj.org/article/364166cdf5514bd08b0ded6877667215
Autor:
Miao Wang, Yugang Zhang, Garrison P. Komaniecki, Xuan Lu, Ji Cao, Mingming Zhang, Tao Yu, Dan Hou, Nicole A. Spiegelman, Ming Yang, Ian R. Price, Hening Lin
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-13 (2022)
Here the authors revealed a role for the protein deacetylase SIRT2 in Golgi stress, particularly induced by bacterial infection. Shigella secrete effector proteins such as IcsB, which transfers fatty acyl groups to modify host proteins to evade host
Externí odkaz:
https://doaj.org/article/d661b6c536494c51b3b9c8d2562bb169
Autor:
Cristiana O’Brien, Tianyi Ling, Jacob M. Berman, Rachel Culp-Hill, Julie A. Reisz, Vincent Rondeau, Soheil Jahangiri, Jonathan St-Germain, Vinitha Macwan, Audrey Astori, Andy Zeng, Jun Young Hong, Meng Li, Min Yang, Sadhan Jana, Fabia Gamboni, Emily Tsao, Weiyi Liu, John E. Dick, Hening Lin, Ari Melnick, Anastasia Tikhonova, Andrea Arruda, Mark D. Minden, Brian Raught, Angelo D'Alessandro, Courtney L. Jones
Publikováno v:
Haematologica, Vol 108, Iss 9 (2023)
Outcomes for patients with acute myeloid leukemia (AML) remain poor due to the inability of current therapeutic regimens to fully eradicate disease-initiating leukemia stem cells (LSC). Previous studies have demonstrated that oxidative phosphorylatio
Externí odkaz:
https://doaj.org/article/365041b041f04292a5cd13ba5d068c3d
Autor:
Yun Yang, Victor Tapias, Diana Acosta, Hui Xu, Huanlian Chen, Ruchika Bhawal, Elizabeth T. Anderson, Elena Ivanova, Hening Lin, Botir T. Sagdullaev, Jianer Chen, William L. Klein, Kirsten L. Viola, Sam Gandy, Vahram Haroutunian, M. Flint Beal, David Eliezer, Sheng Zhang, Gary E. Gibson
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-19 (2022)
Succinylation is a metabolism-associated post-translational protein modification. Here the authors describe changes to the succinylation of proteins in the brain of individuals with Alzheimer’s disease.
Externí odkaz:
https://doaj.org/article/8849caad15a2425b9a9463a3e1b93bff
Autor:
Tatsiana Kosciuk, Ian R. Price, Xiaoyu Zhang, Chengliang Zhu, Kayla N. Johnson, Shuai Zhang, Steve L. Halaby, Garrison P. Komaniecki, Min Yang, Caroline J. DeHart, Paul M. Thomas, Neil L. Kelleher, J. Christopher Fromme, Hening Lin
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-17 (2020)
Lysine fatty acylation is an important protein posttranslational modification but mammalian lysine fatty acyl transferases have remained unknown so far. Here the authors report that the human N-terminal glycine myristoyltransferases 1 and 2 catalyze
Externí odkaz:
https://doaj.org/article/2680a250e1e54ba7aecb1d6f4993fea7
Autor:
Jun Young Hong, Hening Lin
Publikováno v:
Frontiers in Pharmacology, Vol 12 (2021)
Sirtuins use NAD+ to remove various acyl groups from protein lysine residues. Through working on different substrate proteins, they display many biological functions, including regulation of cell proliferation, genome stability, metabolism, and cell
Externí odkaz:
https://doaj.org/article/9f055adef55b45598d467bc3f6354518
Autor:
Garrison Komaniecki, Hening Lin
Publikováno v:
Frontiers in Cell and Developmental Biology, Vol 9 (2021)
Post-translational acylation of lysine side chains is a common mechanism of protein regulation. Modification by long-chain fatty acyl groups is an understudied form of lysine acylation that has gained increasing attention recently due to the characte
Externí odkaz:
https://doaj.org/article/222ee9a36fb542b4aa372d5a0ec8f708
Publikováno v:
ACS Central Science, Vol 4, Iss 1, Pp 71-80 (2017)
The KRAS gene encodes two isoforms, KRas4a and KRas4b. Differences in the signaling functions of the two KRas proteins are poorly understood. Here we report the comparative and nucleotide-dependent interactomes of KRas4a and KRas4b. Many previously u
Externí odkaz:
https://doaj.org/article/4bb96cfea1bc48e89fe0b84aa44e06ea
Autor:
Hui Jing, Xiaoyu Zhang, Stephanie A Wisner, Xiao Chen, Nicole A Spiegelman, Maurine E Linder, Hening Lin
Publikováno v:
eLife, Vol 6 (2017)
Ras proteins play vital roles in numerous biological processes and Ras mutations are found in many human tumors. Understanding how Ras proteins are regulated is important for elucidating cell signaling pathways and identifying new targets for treatin
Externí odkaz:
https://doaj.org/article/a314c067e5cd4722ac95d98f23e7767a