Inhalable ciprofloxacin/polymyxin B dry powders in respiratory infection therapy

Autor: Zhengqi Xu, Hriday Bera, Hengzhuang Wang, Junwei Wang, Dongmei Cun, Yu Feng, Mingshi Yang

Publikováno v: Acta Materia Medica, Vol 2, Iss 2, Pp 142-156 (2023)

The current study focused on the formulation, physicochemical characterization, and antibacterial susceptibility testing of inhalable spray dried powders containing ciprofloxacin (CIP) and polymyxin B sulfate (PMB). CIP nanosuspensions with an averag

Externí odkaz: https://doaj.org/article/2a80f44489d944d680721d9f8b68baed

Antimicrobial Activity of α-Peptide/β-Peptoid Lysine-Based Peptidomimetics Against Colistin-Resistant Pseudomonas aeruginosa Isolated From Cystic Fibrosis Patients

Autor: Natalia Molchanova, Hengzhuang Wang, Paul R. Hansen, Niels Høiby, Hanne M. Nielsen, Henrik Franzyk

Publikováno v: Frontiers in Microbiology, Vol 10 (2019)

Pseudomonas aeruginosa infection is a predominant cause of morbidity and mortality in patients with cystic fibrosis infection and with a compromised immune system. Emergence of bacterial resistance renders existing antibiotics inefficient, and theref

Externí odkaz: https://doaj.org/article/a579e12a071e419c9a6f2b2918337c57

Antimicrobial Activity of α-Peptide/β-Peptoid Lysine-Based Peptidomimetics Against Colistin-Resistant Pseudomonas aeruginosa Isolated From Cystic Fibrosis Patients

Autor: Henrik Franzyk, Paul R. Hansen, Niels Høiby, Hengzhuang Wang, Natalia Molchanova, Hanne Mørck Nielsen

Publikováno v: Frontiers in Microbiology, Vol 10 (2019)
Molchanova, N, Wang, H, Hansen, P R, Høiby, N, Nielsen, H M & Franzyk, H 2019, ' Antimicrobial Activity of α-Peptide/β-Peptoid Lysine-Based Peptidomimetics Against Colistin-Resistant Pseudomonas aeruginosa Isolated From Cystic Fibrosis Patients ', Frontiers in Microbiology, vol. 10, 275 . https://doi.org/10.3389/fmicb.2019.00275

Pseudomonas aeruginosa infection is a predominant cause of morbidity and mortality in patients with cystic fibrosis infection and with a compromised immune system. Emergence of bacterial resistance renders existing antibiotics inefficient, and theref

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ca6315fc366b846632de3f898d6b21f5
https://doi.org/10.3389/fmicb.2019.00275

Formation of hydroxyl radicals contributes to the bactericidal activity of ciprofloxacin againstPseudomonas aeruginosabiofilms

Autor: Mette Kolpen, Peter Østrup Jensen, Thomas Bjarnsholt, Casper Hempel, Alejandra Briales, Hengzhuang Wang, Niels Høiby, Rikke Prejh Brochmann, Oana Ciofu, Kasper Nørskov Kragh

Publikováno v: Pathogens and Disease. 70:440-443

Antibiotic-tolerant, biofilm-forming Pseudomonas aeruginosa has long been recognized as a major cause of chronic lung infections of cystic fibrosis patients. The mechanisms involved in the activity of antibiotics on biofilm are not completely clear.

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::18e4d0b2fd2e1923a71acd1d40c6fc21
https://doi.org/10.1111/2049-632x.12120

Colistin‐Tobramycin Combinations Are Superior to Monotherapy Concerning the Killing of BiofilmPseudomonas aeruginosa

Autor: Martina Ulrich, Liang Yang, Gerd Döring, Niels Høiby, Søren Molin, Hong Wu, Hengzhuang Wang, Gloria Herrmann, Zhijun Song, Joachim Riethmüller

Publikováno v: The Journal of Infectious Diseases. 202:1585-1592

BACKGROUND Antibiotic combination therapy might be more efficient than single antibiotics to combat Pseudomonas aeruginosa biofilms in the airways of patients with cystic fibrosis. We tested the ability of colistin sulphate-tobramycin combinations an

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6206e1918a801f6d40dd93112a87f627
https://doi.org/10.1086/656788