Výsledky vyhledávání - "Hengxian Cui"

Species-Selective Targeting of Fungal Hsp90: Design, Synthesis, and Evaluation of Novel 4,5-Diarylisoxazole Derivatives for the Combination Treatment of Azole-Resistant Candidiasis

Autor: Wenbo Yin, Tianxiao Wu, Lei Liu, Hong Jiang, Yuxin Zhang, Hengxian Cui, Yin Sun, Qiaohua Qin, Yixiang Sun, Zixuan Gao, Liyu Zhao, Xin Su, Dongmei Zhao, Maosheng Cheng

Publikováno v: Journal of medicinal chemistry. 65(7)

Invasive fungal infections are emerging as serious infectious diseases worldwide. Because of the development of antifungal drug resistance, the limited efficacy of the existing drugs has led to high mortality in patients. The use of the essential euk

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8d7aed37602cff447989645ffc3ebbd4
https://pubmed.ncbi.nlm.nih.gov/35298171

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Design, synthesis, and evaluation of novel 3-thiophene derivatives as potent fungistatic and fungicidal reagents based on a conformational restriction strategy

Autor: Wenbo Yin, Lei Liu, Hong Jiang, Tianxiao Wu, Hengxian Cui, Yuxin Zhang, Zixuan Gao, Yin Sun, Qiaohua Qin, Liyu Zhao, Xin Su, Dongmei Zhao, Maosheng Cheng

Publikováno v: European journal of medicinal chemistry. 233

Invasive fungal infections (IFIs) are emerging as serious infectious diseases worldwide, and due to the lack of effective antifungal agents and serious drug resistance, the limited efficacy of existing drugs has led to high morbidity and mortality in

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f28ee136d75022546ea4ee29bd05fbf0
https://pubmed.ncbi.nlm.nih.gov/35255313

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Design, synthesis and evaluation of novel 5-phenylthiophene derivatives as potent fungicidal of Candida albicans and antifungal reagents of fluconazole-resistant fungi

Autor: Dongmei Zhao, Lei Liu, Tianxiao Wu, Hengxian Cui, Hong Jiang, Yuxin Zhang, Maosheng Cheng, Yang Zheng, Yin Sun, Xin Su, Song Li, Liyu Zhao, Wenbo Yin

Publikováno v: European journal of medicinal chemistry. 225

A series of 5-phenylthiophene derivatives with novel structures were designed and synthesized to combat the increasing incidence of susceptible and drug-resistant fungal infections. The antifungal activity of the synthesized compounds was assessed ag

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::679a4a6bdc6c18434e560c1ab0f28300
https://pubmed.ncbi.nlm.nih.gov/34388384

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Broadening antifungal spectrum and improving metabolic stablity based on a scaffold strategy: Design, synthesis, and evaluation of novel 4-phenyl-4,5-dihydrooxazole derivatives as potent fungistatic and fungicidal reagents

Autor: Dongmei Zhao, Liyu Zhao, Wenbo Yin, Hengxian Cui, Xin Su, Hong Jiang, Tianxiao Wu, Lei Liu, Maosheng Cheng, Yin Sun, Yuxin Zhang

Publikováno v: European Journal of Medicinal Chemistry. 227:113955

5-phenylthiophene derivatives exhibited excellent antifungal activity against Candida albicans, Candida tropicalis and Cryptococcus neoformans. However, optimal compound 7 was inactive against Aspergillus fumigatus and unstable in human liver microso

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b9b670ebe1e7e561154f5bfcbbb0a838
https://doi.org/10.1016/j.ejmech.2021.113955

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Discovery of 7H-pyrrolo[2,3-d]pyridine derivatives as potent FAK inhibitors: Design, synthesis, biological evaluation and molecular docking study

Autor: Dongmei Zhao, Ruifeng Wang, Xiangxin Zhao, Maosheng Cheng, Hengxian Cui, Chenzhou Hao, Tianxiao Wu, Yixuan Chen, Sijia Yu

Publikováno v: Bioorganic Chemistry. 102:104092

Focal adhesion kinase (FAK) is an intracellular non-receptor tyrosine kinase responsible for development of various tumor types. Aiming to explore new potent inhibitors, two series of 2,4-disubstituted-7H-pyrrolo[2,3-d]pyrimidine derivatives were des

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6ef4f3f06d1420e54945359bfed03b6b
https://doi.org/10.1016/j.bioorg.2020.104092

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