Zobrazeno 1 - 2
of 2
pro vyhledávání: '"Hengqiao Shen"'
Autor:
Gai Kuo, Yuan Cao, Hui Qin, Qin Lu, Deyang Chen, Baomin Liu, Yinsheng Zhang, Liu Xushi, Lu Dandan, Hongjiang Xu, Jia Mei, Hengqiao Shen, Song Wei, Xiaojin Wang, Jie Wang
Publikováno v:
Journal of Medicinal Chemistry. 63:5312-5323
We describe a study leading to the discovery of compound 11, a pan-genotypic hepatitis C virus (HCV) nonstructural protein 5A (NS5A) inhibitor with excellent potency, metabolic stability, and pharmacokinetics (PK). Compound 11 incorporating a 4-silap
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ea49bc8239ef727d199caea4d427634d
https://doi.org/10.1021/acs.jmedchem.0c00082
https://doi.org/10.1021/acs.jmedchem.0c00082
Autor:
Gai Kuo, Lu Dandan, Wei Song, Qin Lu, Hui Qin, Yuan Cao, Yinsheng Zhang, Liu Xushi, Hengqiao Shen, Xiaojin Wang, Baomin Liu, Deyang Chen, Zhang Yang, Hongjiang Xu
Publikováno v:
European journal of medicinal chemistry. 148
Modification of a HCV NS5A inhibitor, ombitasvir, led to the identification of 10d with improved pan-genotype NS5A inhibition and better pharmacokinetic properties. The key structural changes to ombitasvir include bioisosteric replacement of carbon w
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::71ac30484680963dd7fe54ad46ba3ecd
https://pubmed.ncbi.nlm.nih.gov/29454920
https://pubmed.ncbi.nlm.nih.gov/29454920