Zobrazeno 1 - 10
of 11
pro vyhledávání: '"Heng-Xiu Yan"'
Autor:
Rong Xiang, Jiao Yang, Weimin Li, Shengyong Yang, Yuquan Wei, Xiao-Juan Jiang, Wei Yang, Lin-Li Li, Jingqiang Zhu, Y. Li, Shenzhen Huang, Kai Chen, Youfu Luo, Heng-Xiu Yan, Guo Zhang, Qiuyuan Yang, Yanlin Wang
Publikováno v:
European Journal of Medicinal Chemistry. 143:1148-1164
The RET tyrosine kinase is an important therapeutic target for medullary thyroid cancer (MTC), and drug resistance mutations of RET, particularly V804M and V804L, are a main challenge for the current targeted therapy of MTC based on RET inhibitors. I
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d0e817739c6ef20f397e562cde63f935
https://doi.org/10.1016/j.ejmech.2017.09.018
https://doi.org/10.1016/j.ejmech.2017.09.018
Autor:
Xiu-Ying Li, Huashan Shi, Shengyong Yang, Yang Wan, Wei-Wei Li, Tao Yin, Heng-Xiu Yan, Guobo Shen, Qing-Yin Zhang, Yuquan Wei, Xiawei Wei, Yan Zhang, Jiong Li, Li-Xin Fu
Publikováno v:
Immunologic Research. 60:112-126
Psoriasis is a common chronic T-cell-mediated autoimmune skin disease, and traditional immunotherapies for psoriasis have focused on the direct inhibition of T cells, which often causes toxicity and lacks long-term effectiveness. Safe and effective t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::00ed4631bc340a595b0bc88a4cd3ff18
https://doi.org/10.1007/s12026-014-8521-4
https://doi.org/10.1007/s12026-014-8521-4
Publikováno v:
Molecular Medicine Reports. 8:434-438
Psoriasis is a common chronic inflammatory skin disease and its underlying pathogenesis is still not fully understood. Therapeutic interventions are currently limited and restricted to the treatment of symptoms rather than targeting the mechanisms un
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8859c58386867929228fe08967ade184
https://doi.org/10.3892/mmr.2013.1500
https://doi.org/10.3892/mmr.2013.1500
Publikováno v:
Oncology Reports. 29:1510-1516
As tumor-associated antigens are not well characterized for the majority of human tumors, polyvalent vaccines prepared with whole-tumor antigens are an attractive approach for tumor vaccination. Vascular endothelial growth factor receptor-2 (VEGFR2),
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d3be7e13631e4cd336d9781378c230ca
https://doi.org/10.3892/or.2013.2282
https://doi.org/10.3892/or.2013.2282
Autor:
Heng-Xiu Yan, Jun Zou, Ze-Rong Wang, Shan Feng, Yang Lingling, Pan Ji, Guo-Bo Li, Qi-Zheng Sun, Shuang Ma, Shengyong Yang
Publikováno v:
European Journal of Medicinal Chemistry. 56:30-38
Aberrant activation of casein kinase 1 (CK1) has been demonstrated to be implicated in the pathogenesis of cancer and various central nervous system disorders. Discovery of CK1 inhibitors has thus attracted much attention in recent years. In this acc
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::38d93b85e223ff3d115e6dcb9623211b
https://doi.org/10.1016/j.ejmech.2012.08.007
https://doi.org/10.1016/j.ejmech.2012.08.007
Autor:
Jing-Jing Liu, Li-Jiao Wang, Shengyong Yang, Chun-Hui Zhang, Yong Xu, Yang Lingling, Jiao Yang, Pan Ji, Shan Feng, Zhi-Xing Cao, Ze-Rong Wang, Lei Zhong, Xiaoyan Wang, Yuquan Wei, Ren-Lin Zheng, Heng-Xiu Yan, Shuang Ma, Wei-Wei Li, Qi-Zheng Sun
Publikováno v:
Journal of medicinal chemistry. 55(8)
Structure-activity relationship (SAR) studies of 2-(quinazolin-4-ylthio)thiazole derivatives, which are for optimizing the in vitro and in vivo antiacute myeloid leukemia (AML) activity of a previously identified FLT3 inhibitor 2-(6,7-dimethoxyquinaz
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8ffdddc2fb343c9f490796ab3ce2cf51
https://pubmed.ncbi.nlm.nih.gov/22452518
https://pubmed.ncbi.nlm.nih.gov/22452518
Autor:
Dandan Li, Chang Yang Gong, Yu Quan Wei, Heng Xiu Yan, Qin Jie Wu, Dong-Mei Zhang, Sha Sha He, Lian Lu, Li Yang, Shuang Zhang, Shun Tao Luo, Xia Zhao, Hua Shan Shi
Publikováno v:
BMC Cancer, Vol 12, Iss 1, p 129 (2012)
BMC Cancer
BMC Cancer
Background Angiogenesis plays an important role in tumor growth and metastasis, therefore antiangiogenic therapy was widely investigated as a promising approach for cancer therapy. Recently, pigment epithelium-derived factor (PEDF) has been shown to
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::928808885ac1329c8464c7252ff6173b
http://www.biomedcentral.com/1471-2407/12/129
http://www.biomedcentral.com/1471-2407/12/129
Publikováno v:
Sichuan da xue xue bao. Yi xue ban = Journal of Sichuan University. Medical science edition. 36(4)
To study the protective effect of tetramethylpyrazine (TMP) on the respiratory inhibition induced by hypoxia.Forty-four SD rats were used. The hypoxic rat model was established. The effects of TMP on the responses of respiratory activity and life tim
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::30918df83dea778b35b085eb68e02bd7
https://pubmed.ncbi.nlm.nih.gov/16078581
https://pubmed.ncbi.nlm.nih.gov/16078581
Autor:
Zi-Cheng, Li, Li, Li, Heng-Xiu, Yan, Hai-Yan, Hu, Yu-Qiong, Ma, Wen-Xing, Yang, Li, Chen, Yu, Zheng
Publikováno v:
Sheng li xue bao : [Acta physiologica Sinica]. 57(2)
The aim of the present study was to investigate the effect of tetramethylpyrazine (TMP) on the changes of respiration and expression of neuronal nitric oxide synthase (nNOS) in brainstem induced by hypoxia in the rats. Hypoxia was induced by inhalati
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::7750e31002a02ecf96dd2b7c071ffdd4
https://pubmed.ncbi.nlm.nih.gov/15830098
https://pubmed.ncbi.nlm.nih.gov/15830098
Publikováno v:
Sheng li xue bao : [Acta physiologica Sinica]. 56(6)
The experiments were carried out on adult Sprague-Dawley rats. We investigated the discharge response of respiratory neurons (RNs) in the pre-Bözinger complex (PBC) to electrical stimulation of the facial nucleus in which the motor neurons were retr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::d284cc8dd68ef2cb3034a24497077155
https://pubmed.ncbi.nlm.nih.gov/15614412
https://pubmed.ncbi.nlm.nih.gov/15614412