Zobrazeno 1 - 10
of 66
pro vyhledávání: '"Heng-Keang Lim"'
Autor:
Zhuming Zhang, Heng-Keang Lim, Jonathan Branch, Vineet Pande, Janine Ondrus, James R. Bischoff, Peter J. Connolly, Bush Tammy, Lieven Meerpoel, Ian Hickson, Christian Rocaboy, Luis B. Trabalón Escolar, Gilles Bignan
Publikováno v:
ACS Med Chem Lett
[Image: see text] Androgen receptor (AR) transcriptional reactivation plays a key role in the development and progression of lethal castration-resistant prostate cancer (CRPC). Recurrent alterations in the AR enable persistent AR pathway signaling an
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::32a2583de003d65667131bf1b1caba4e
https://doi.org/10.1021/acsmedchemlett.1c00032
https://doi.org/10.1021/acsmedchemlett.1c00032
Autor:
Heng-Keang Lim, Jie Chen, Wing Lam, Yong Gong, Laurent Leclercq, Jose Silva, Rhys Salter, Joris Berwaerts, Cathy K. Gelotte, Amy M. Vakil, Gary E. Eichenbaum, Edwin K. Kuffner, Christopher M. Flores
Publikováno v:
Regulatory Toxicology and Pharmacology. :105379
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::c06d22f7772dfc48f646cd0eb5ecb744
https://doi.org/10.1016/j.yrtph.2023.105379
https://doi.org/10.1016/j.yrtph.2023.105379
Autor:
Zhuming Zhang, Yolanda T. Chong, James R. Bischoff, Jonathan Branch, Christopher J. Parrett, Janine Ondrus, Gilles Bignan, Lieven Meerpoel, Kathryn Packman, Leopoldo Luistro, Marco Gottardis, Bush Tammy, Salam H. Ibrahim, Christopher A. Teleha, Vineet Pande, Peter J. Connolly, Heng-Keang Lim, Ian Hickson
Publikováno v:
Journal of Medicinal Chemistry. 64:909-924
Persistent androgen receptor (AR) activation drives therapeutic resistance to second-generation AR pathway inhibitors and contributes to the progression of advanced prostate cancer. One resistance mechanism is point mutations in the ligand binding do
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a913df6dcf096e8ad0ea7030d6423e6f
https://doi.org/10.1021/acs.jmedchem.0c01563
https://doi.org/10.1021/acs.jmedchem.0c01563
Publikováno v:
Biomedical chromatography : BMCREFERENCES. 36(1)
The reported method involves a novel workflow that eliminates the need for authentic reference standards for the quantitation of drug metabolites in biological samples using a single multi-isotopically labeled compound bearing both radio and stable i
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b84f2a07185da23deae549b5717dbbd5
https://pubmed.ncbi.nlm.nih.gov/34519061
https://pubmed.ncbi.nlm.nih.gov/34519061
Autor:
Hollie Skaggs, Heng-Keang Lim, Damir Simic, Alessandro Pocai, Wing W. Lam, Mark R. Player, Rhys Salter, Bhanu Singh, Monicah A. Otieno, Jan Snoeys, Avi Ghosh
Publikováno v:
Toxicological Sciences. 163:374-384
TAK-875, a GPR40 agonist, was withdrawn from Phase III clinical trials due to drug-induced liver injury (DILI). Mechanistic studies were conducted to identify potential DILI hazards (covalent binding burden (CVB), hepatic transporter inhibition, mito
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::98c8dabc0d28e07f9ae32807bc3b23e3
https://doi.org/10.1093/toxsci/kfx040
https://doi.org/10.1093/toxsci/kfx040
Autor:
Erio Barale, Katia Karalis, Riccardo Barrile, Kyung-Jin Jang, Monica Singer, Abhishek Srivastava, Anna Herland, Josiah Sliz, Barry Jones, Hyoungshin Park, Janna Nawroth, Geraldine A. Hamilton, Dominic P. Williams, Wing W. Lam, Gauri Kulkarni, Jonathan E. Rubins, Suzzette Haney, Linda C. Andersson, Manisha Sonee, Konstantia Kodella, Debora B. Petropolis, Monicah A. Otieno, Heng-Keang Lim, Lorna Ewart, Bhanu Singh, Carl L. Manthey, Janey Ronxhi, Donald E. Ingber, David Conegliano, Anthony J. Streeter, Damir Simic
Nonclinical rodent and non-rodent toxicity models used to support clinical trials of candidate drugs may produce discordant results or fail to predict complications in humans contributing to drug failures in the clinic. Here we applied microengineere
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::77153c2fec6be0820279936c4ea70992
Autor:
Bhanu Singh, Suzzette Haney, Carl L. Manthey, Riccardo Barrile, Anna Herland, Dominic P. Williams, Manisha Sonee, Katia Karalis, Monica Singer, David Conegliano, Heng-Keang Lim, Geraldine A. Hamilton, Donald E. Ingber, Monicah A. Otieno, Anthony J. Streeter, Lorna Ewart, Erio Barale, Linda C. Andersson, Barry Jones, Wing W. Lam, Damir Simic, Konstantia Kodella, Debora B. Petropolis, Josiah Sliz, Janey Ronxhi, Janna Nawroth, Abhishek Srivastava, Kyung-Jin Jang, Gauri Kulkarni, Hyoungshin Park, Jonathan E. Rubins
Publikováno v:
Science translational medicine. 11(517)
Nonclinical rodent and nonrodent toxicity models used to support clinical trials of candidate drugs may produce discordant results or fail to predict complications in humans, contributing to drug failures in the clinic. Here, we applied microengineer
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1e12fac7c745aecb2cdd286e4f142c77
https://pubmed.ncbi.nlm.nih.gov/31776474
https://pubmed.ncbi.nlm.nih.gov/31776474
Publikováno v:
Analytical chemistry. 91(3)
A high resolution accurate mass LC-MS method was developed to facilitate the characterization of a subset of antibody drug conjugate (ADC) biotherapeutics, where the payload is linked to the antibody by a thioether bond. Desulfuration of the thioethe
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cdcac38892c78383d8e32e6e06ad9903
https://pubmed.ncbi.nlm.nih.gov/30609358
https://pubmed.ncbi.nlm.nih.gov/30609358
Autor:
Sanath K. Meegalla, Jose Silva, Thomas Wilde, Michael P. Winters, Jianying Liu, Fran Xu, Shuyuan Zhao, Brian Rady, Jenson Qi, Alessandro Pocai, Paul S. Lee, Tonya Martin, Mark R. Player, James Littrell, Monicah A. Otieno, Wing W. Lam, James C. Lanter, Heng-Keang Lim, Hui Huang
[Image: see text] GPR40 is a G-protein-coupled receptor which mediates fatty acid-induced glucose-stimulated insulin secretion from pancreatic beta cells and incretion release from enteroendocrine cells of the small intestine. GPR40 full agonists exh
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5dd9c88f3c2b104a8517817db45fd252
https://europepmc.org/articles/PMC6331191/
https://europepmc.org/articles/PMC6331191/
Autor:
Wim Bert Griet Schepens, Gilles Bignan, Leo Luistro, Sally Mahady, Monica Singer, Jocelyn Sendecki, Peter J. Connolly, James P. Edwards, Liam Campion, Kathryn Packman, Jan Willem Thuring, Hayley Ta, Nancy Bogdan, Shefali Patel, Caitlin Morgan, Daniel Jason Krosky, Emily Pierson, Glenn Van Aller, Melissa Smith, Thomas Wilde, Monicah A. Otieno, Michael J. Allegrezza, Heng-Keang Lim, Diana Wiley, Szeman Ruby Chan, Kim Staquet, Stuart L. Emanuel
Publikováno v:
Cancer Research. 80:5567A-5567A
The Stimulator of Interferon Genes (STING) protein is a key mediator of innate immunity that plays a central role in the immune response to invading pathogens (bacterial, viral) and transformed cells. A next generation human STING agonist, JNJ-‘619
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::07931370687a649935a23154b8af8420
https://doi.org/10.1158/1538-7445.am2020-5567a
https://doi.org/10.1158/1538-7445.am2020-5567a