Zobrazeno 1 - 10
of 70
pro vyhledávání: '"Heng-Fu Bu"'
Publikováno v:
Frontiers in Immunology, Vol 14 (2024)
Clinical evidence indicates a connection between gut injuries, infections, inflammation, and an increased susceptibility to systemic inflammation. Nevertheless, the animal models designed to replicate this progression are inadequate, and the fundamen
Externí odkaz:
https://doaj.org/article/dd5a4197f74e4e39a9d8828dba7d099c
Autor:
Hua Geng, Saravanan Subramanian, Longtao Wu, Heng-Fu Bu, Xiao Wang, Chao Du, Isabelle G. De Plaen, Xiao-Di Tan
Publikováno v:
Frontiers in Immunology, Vol 12 (2021)
Infection with the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) causes COVID-19, a disease that involves significant lung tissue damage. How SARS-CoV-2 infection leads to lung injury remains elusive. The open reading frame 8 (ORF8) pr
Externí odkaz:
https://doaj.org/article/a8c0f54535bf427e998a84b7df82a8ca
Autor:
Fangyi Liu, Heng-Fu Bu, Hua Geng, Isabelle G. De Plaen, Chao Gao, Peng Wang, Xiao Wang, Jacob A. Kurowski, Hong Yang, Jiaming Qian, Xiao-Di Tan
Publikováno v:
Molecular Medicine, Vol 23, Iss 1, Pp 272-284 (2017)
Abstract Sirtuin-6 (Sirt6) is a critical epigenetic regulator, but its function in the gut is unknown. Here, we studied the role of intestinal epithelial Sirt6 in colitis-associated intestinal epithelial injury. We found that Sirt6, which is predomin
Externí odkaz:
https://doaj.org/article/1c94b458304041a7aff4bd5d8e77ed41
Autor:
Heng-Fu Bu, Saravanan Subramanian, Hua Geng, Xiao Wang, Fangyi Liu, Pauline M. Chou, Chao Du, Isabelle G. De Plaen, Xiao-Di Tan
Publikováno v:
Cells, Vol 10, Iss 4, p 728 (2021)
Milk fat globule-EGF factor 8 (MFG-E8) is a secreted glycoprotein that regulates tissue homeostasis, possesses potent anti-inflammatory properties, and protects against tissue injury. The human pancreas expresses MFG-E8; however, the role of MFG-E8 i
Externí odkaz:
https://doaj.org/article/32985d03b0114b0ba60179522950350d
Publikováno v:
Molecular Medicine, Vol 19, Iss 1, Pp 170-182 (2013)
Abstract Efferocytosis is a unique phagocytic process for macrophages to remove apoptotic cells in inflammatory loci. This event is maintained by milk fat globule-EGF factor 8 (MFG-E8), but attenuated by high mobility group box 1 (HMGB1). Alcohol abu
Externí odkaz:
https://doaj.org/article/cbec029c58aa493192093111fbb5e54e
Autor:
Tonyia Eaves-Pyles, Heng-Fu Bu, Xiao-di Tan, Yingzi Cong, Jignesh Patel, Robert A Davey, Jane E Strasser
Publikováno v:
PLoS ONE, Vol 6, Iss 9, p e24869 (2011)
Bacteria release flagellin that elicits innate responses via Toll-like receptor 5 (TLR5). Here, we investigated the fate of apically administrated full length flagellin from virulent and avirulent bacteria, along with truncated recombinant flagellin
Externí odkaz:
https://doaj.org/article/85cfc6fa8a704b51ac9a3ce8fcf5b68b
Publikováno v:
Frontiers in Immunology; 2024, p1-14, 14p
Autor:
Saravanan Subramanian, Hua Geng, Chao Du, Pauline M. Chou, Heng-Fu Bu, Xiao Wang, Suchitra Swaminathan, Stephanie C. Tan, Jason M. Ridlon, Isabelle G. De Plaen, Xiao-Di Tan
Publikováno v:
American journal of physiology. Gastrointestinal and liver physiology. 323(3)
Feeding modes influence the gut microbiome, immune system, and intestinal barrier homeostasis in neonates; how feeding modes impact susceptibility to neonatal gastrointestinal (GI) diseases is still uncertain. Here, we investigated the impact of dam
Autor:
Saravanan Subramanian, Heng-Fu Bu, Xiao Wang, Pauline M Chou, Hua Geng, Wen-Xing Ding, Isabelle G. De Plaen, Xiao-Di Tan
Publikováno v:
Physiology. 38
Necrotizing enterocolitis (NEC) is a devastating gastrointestinal disease of preterm infants characterized by intestinal inflammation and intestinal epithelial cells (IEC) death. Evidence suggests that scattered crypt IEC apoptosis is a critical path
Publikováno v:
Physiology. 38
Being recognized as a typical pathological feature of liver diseases, apoptosis-induced hepatocyte injury leading to sterile inflammation drives a wound-healing path in vivo. We and other researchers reported that Milk fat globule-EGF factor 8 (MFGE8