Zobrazeno 1 - 8
of 8
pro vyhledávání: '"Heng Tai Liew"'
Autor:
Side Hu, Seetharamsing Balamkundu, James P. Tam, Heng Tai Liew, Janet To, Xiaohong Zhang, Julien Lescar, Chuan-Fa Liu, Surajit Bhattacharjya, Ning-Yu Chan, Yiyin Xia
Publikováno v:
Angewandte Chemie. 133:22381-22385
Peptidyl asparaginyl ligases (PALs) are powerful tools for peptide macrocyclization. Herein, we report that a derivative of Asn, namely Nγ -hydroxyasparagine or Asn(OH), is an unnatural P1 substrate of PALs. By Asn(OH)-mediated cyclization, we prepa
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::af6b33c50224dba4f6e15de1b10b312a
https://doi.org/10.1002/ange.202108125
https://doi.org/10.1002/ange.202108125
Autor:
Xinya Hemu, Ning‐Yu Chan, Heng Tai Liew, Side Hu, Xiaohong Zhang, Aida Serra, Julien Lescar, Chuan‐Fa Liu, James P. Tam
Peptide asparaginyl ligases (PALs) are Asn/Asp(Asx)-specific ligases that are useful for precision modifications of proteins and live-cell surfaces. PALs share high sequence and structural similarity to legumains, asparaginyl endopeptidases (AEPs) th
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2534085a5de724bc7d6e550d09b33d19
https://doi.org/10.1101/2022.09.26.509423
https://doi.org/10.1101/2022.09.26.509423
Autor:
Dingpeng Zhang, Zhen Wang, Side Hu, Ning-Yu Chan, Heng Tai Liew, Julien Lescar, James P. Tam, Chuan-Fa Liu
Publikováno v:
Bioconjugate chemistry. 33(1)
Asparaginyl endopeptidases (AEPs) are cysteinyl enzymes naturally catalyzing the hydrolysis and transpeptidation reactions at Asx-Xaa bonds. These reactions go by a common acyl-enzyme thioester intermediate, which is either attacked by water (for a p
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5583d6b47df9b4e1a6fd5fbd9804b728
https://pubmed.ncbi.nlm.nih.gov/34985285
https://pubmed.ncbi.nlm.nih.gov/34985285
Autor:
Yiyin, Xia, Janet, To, Ning-Yu, Chan, Side, Hu, Heng Tai, Liew, Seetharamsing, Balamkundu, Xiaohong, Zhang, Julien, Lescar, Surajit, Bhattacharjya, James P, Tam, Chuan-Fa, Liu
Publikováno v:
Angewandte Chemie (International ed. in English). 60(41)
Peptidyl asparaginyl ligases (PALs) are powerful tools for peptide macrocyclization. Herein, we report that a derivative of Asn, namely N
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::c995c35b64af49d225a65cc4adc3d66c
https://pubmed.ncbi.nlm.nih.gov/34396662
https://pubmed.ncbi.nlm.nih.gov/34396662
Making peptide bonds is tightly controlled by genetic code and machinery which includes cofactors, ATP, and RNAs. In this regard, the stand-alone and genetic-code-independent peptide ligases constitute a new family of renegade peptide-bond makers. A
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::efd6d302801657fd5a02e4bff44b8e21
https://hdl.handle.net/10356/148282
https://hdl.handle.net/10356/148282
Autor:
Aida Serra, James P. Tam, Chuan-Fa Liu, Heng Tai Liew, Xinya Hemu, Xiaohong Zhang, Siu Kwan Sze, Janet To, Ning-Yu Chan
Publikováno v:
The Journal of Biological Chemistry
Legumains, also known as asparaginyl endopeptidases (AEPs), cleave peptide bonds after Asn/Asp (Asx) residues. In plants, certain legumains also have ligase activity that catalyzes biosynthesis of Asx-containing cyclic peptides. An example is the bio
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::14c9fb90642791a2161e47c088998917
https://doi.org/10.1016/j.jbc.2021.101325
https://doi.org/10.1016/j.jbc.2021.101325
Autor:
Heng Tai Liew1, To, Janet1, Xiaohong Zhang1, Xinya Hemu1, Ning-Yu Chan1, Serra, Aida2,3, Siu Kwan Sze1, Chuan-fa Liu1, Tam, James P.1 jptam@ntu.edu.sg
Publikováno v:
Journal of Biological Chemistry. Dec2021, Vol. 297 Issue 6, p1-13. 13p.
Autor:
Hon Lun Wong, Brendan P. Burns, Luděk Sehnal, Brett A. Neilan, Jason N. Woodhouse, Heng Tai Liew, Russel Pickford, Paul M. D'Agostino
Publikováno v:
Environmental microbiology. 21(2)
Shark Bay, Western Australia is a World Heritage area with extensive microbial mats and stromatolites. Microbial communities that comprise these mats have developed a range of mitigation strategies against changing levels of photosynthetically active
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2d02123e0df31e1328d0647918e5ebed
https://pubmed.ncbi.nlm.nih.gov/30589201
https://pubmed.ncbi.nlm.nih.gov/30589201