Zobrazeno 1 - 10
of 17
pro vyhledávání: '"Heng Keat Tam"'
Autor:
Coline Plé, Heng-Keat Tam, Anais Vieira Da Cruz, Nina Compagne, Juan-Carlos Jiménez-Castellanos, Reinke T. Müller, Elizabeth Pradel, Wuen Ee Foong, Giuliano Malloci, Alexia Ballée, Moritz A. Kirchner, Parisa Moshfegh, Adrien Herledan, Andrea Herrmann, Benoit Deprez, Nicolas Willand, Attilio Vittorio Vargiu, Klaas M. Pos, Marion Flipo, Ruben C. Hartkoorn
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-11 (2022)
Efflux transporters of the RND family confer resistance to multiple antibiotics in Gram-negative bacteria. Here, the authors identify pyridylpiperazine-based compounds that potentiate antibiotic activity in E. coli through allosteric inhibition of it
Externí odkaz:
https://doaj.org/article/2d5e83c99b5c4265bf969d47fed84ba5
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-10 (2021)
Gram-negative bacteria can display intrinsic antibiotic resistance due to the action of tripartite efflux pumps, which include a H+/drug antiporter component. Here, the authors present a structure-function analysis of antiporter AcrB in intermediate
Externí odkaz:
https://doaj.org/article/6482f47ba7254e868df9dbcc9afdc705
Autor:
Manuela Sumyk, Stephanie Himpich, Wuen Ee Foong, Andrea Herrmann, Klaas M. Pos, Heng-Keat Tam
Publikováno v:
Frontiers in Microbiology, Vol 12 (2021)
Acinetobacter baumannii is an important nosocomial pathogen that requires thoughtful consideration in the antibiotic prescription strategy due to its multidrug resistant phenotype. Tetracycline antibiotics have recently been re-administered as part o
Externí odkaz:
https://doaj.org/article/7078066933ec4613b75534d886a22ae8
Autor:
Heng Keat Tam
Publikováno v:
TheScienceBreaker. 9
Nosocomial infection has become a serious global challenge in modern healthcare facilities due to the persistence of superbugs. To survive in highly sanitized hospitals, superbugs produce beneficial substances such as mannitol to sustain their growth
Publikováno v:
Nature Communications, Vol 7, Iss 1, Pp 1-10 (2016)
The AcrB module of the AcrAB-TolC multidrug efflux pump sequesters drugs from the periplasm and outer leaflet of the inner membrane. Here, Oswaldet al. provide evidence that lipophilic carboxylated substrates bind to a groove between transmembrane he
Externí odkaz:
https://doaj.org/article/fa3b0c6a09c14ed89a4c26f47061ebab
Autor:
Heng-Keat, Tam, Patricia, König, Stephanie, Himpich, Ngoc Dinh, Ngu, Rupert, Abele, Volker, Müller, Klaas M, Pos
Publikováno v:
Proceedings of the National Academy of Sciences of the United States of America. 119(14)
Persistence of Acinetobacter baumannii in environments with low water activity is largely attributed to the biosynthesis of compatible solutes. Mannitol is one of the key compatible solutes in A. baumannii, and it is synthesized by a bifunctional man
Publikováno v:
Methods in molecular biology (Clifton, N.J.). 1700
X-ray crystallography is still the most prominent technique in use to decipher the 3D structures of membrane proteins. For successful crystallization, sample quality is the most important parameter that should be addressed. In almost every case, high
Publikováno v:
Methods in Molecular Biology ISBN: 9781493974528
X-ray crystallography is still the most prominent technique in use to decipher the 3D structures of membrane proteins. For successful crystallization, sample quality is the most important parameter that should be addressed. In almost every case, high
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::0e3a1b0e598ee20aee230282e1d782d5
https://doi.org/10.1007/978-1-4939-7454-2_1
https://doi.org/10.1007/978-1-4939-7454-2_1
Autor:
Heng Keat Tam, Jenny M. Blamey, Sheau Ting Yong, Marcelo Gonzalez, Clemente Michael Vui Ling Wong
Publikováno v:
Polar Biology. 38:1129-1141
The existence of multiple-antibiotic-resistant strains of environmental bacteria is commonly linked to human activities. However, multiple-antibiotic-resistant strains of bacteria are also widely found in the Antarctic that has limited human activity
Autor:
Wolfgang Seiche, Andreas Bechthold, Monika Lutterbeck, Jürgen Rohr, Heng Keat Tam, Stefan Gerhardt, Guojun Wang, Jon S. Thorson, Aurelien Bigot, Bernhard Breit, Oliver Einsle, Johannes Härle
Publikováno v:
Angewandte Chemie International Edition. 54:2811-2815
The structures of the O-glycosyltransferase LanGT2 and the engineered, C-C bond-forming variant LanGT2S8Ac show how the replacement of a single loop can change the functionality of the enzyme. Crystal structures of the enzymes in complex with a nonhy