Zobrazeno 1 - 10
of 10
pro vyhledávání: '"Heng Boon Low"'
Autor:
Saket Jhajharia, Fritz Lai, Heng Boon Low, Kiren Purushotorman, Bhuvaneshwari D/O Shunmuganathan, Conrad En Zuo Chan, Rachel Hammond, Hans-Jürgen Netter, Qingfeng Chen, Seng Gee Lim, Paul A. MacAry
Publikováno v:
npj Vaccines, Vol 7, Iss 1, Pp 1-9 (2022)
Abstract Hepatitis B Virus (HBV) is a hepadnavirus that is the principal pathogen underlying viral liver disease in human populations. In this study, we describe the isolation and characterization of a fully human monoclonal antibody for HBV. This Hu
Externí odkaz:
https://doaj.org/article/fb283a36a7c34a808b9658dccca347d5
Autor:
Heng Boon Low, Zhen Lim Wong, Bangyuan Wu, Li Ren Kong, Chin Wen Png, Yik-Lam Cho, Chun-Wei Li, Fengchun Xiao, Xuan Xin, Henry Yang, Jia Min Loo, Fiona Yi Xin Lee, Iain Bee Huat Tan, Ramanuj DasGupta, Han-Ming Shen, Herbert Schwarz, Nicholas R. J. Gascoigne, Boon Cher Goh, Xiaohong Xu, Yongliang Zhang
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-16 (2021)
Chemoresistance is one of the main challenges for cancer therapy success. Here, the authors show that dual-specificity phosphatase 16 (DUSP16) expression is associated with chemoresistance in several types of cancer through impairing mitochondria-ass
Externí odkaz:
https://doaj.org/article/7cd1e1ed821d475f86d18b8927eabe0d
Autor:
Peng Tang, Heng Boon Low, Chin Wen Png, Federico Torta, Jaspal Kaur Kumar, Hwee Ying Lim, Yi Zhou, Henry Yang, Veronique Angeli, Asim Shabbir, E. Shyong Tai, Richard A. Flavell, Chen Dong, Markus R. Wenk, Dan Yock Yang, Yongliang Zhang
Publikováno v:
Hepatology Communications, Vol 3, Iss 6, Pp 748-762 (2019)
Nonalcoholic fatty liver disease is currently the most common liver disease and is a leading cause of liver‐related morbidity and mortality. However, its pathogenesis remains largely unclear. We previously showed that mice deficient in mitogen‐ac
Externí odkaz:
https://doaj.org/article/d7ddb9f8e28d4b1b8b018d617b1c1aeb
Autor:
Yongliang Zhang, Heng Boon Low, Yik-Lam Cho, Herbert Schwarz, Nicholas R. J. Gascoigne, Fengchun Xiao, Chin Wen Png, Fiona Yi Xin Lee, Xiaohong Xu, Bangyuan Wu, Jia Min Loo, Han-Ming Shen, Li Ren Kong, Henry Yang, Ramanuj DasGupta, Zhen Lim Wong, Xuan Xin, Chun-Wei Li, Boon Cher Goh, Iain Beehuat Tan
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-16 (2021)
Nature Communications
Nature Communications
Drug resistance is a major obstacle to the treatment of most human tumors. In this study, we find that dual-specificity phosphatase 16 (DUSP16) regulates resistance to chemotherapy in nasopharyngeal carcinoma, colorectal cancer, gastric and breast ca
Autor:
Chen Dong, Yongliang Zhang, Federico Torta, Jaspal Kaur Kumar, Richard A. Flavell, Hwee Ying Lim, Heng Boon Low, Dan Yock Yang, Markus R. Wenk, Veronique Angeli, Yi Zhou, Asim Shabbir, Henry Yang, E. Shyong Tai, Chin Wen Png, Peng Tang
Publikováno v:
Hepatology Communications
Hepatology Communications, Vol 3, Iss 6, Pp 748-762 (2019)
Hepatology Communications, Vol 3, Iss 6, Pp 748-762 (2019)
Nonalcoholic fatty liver disease is currently the most common liver disease and is a leading cause of liver‐related morbidity and mortality. However, its pathogenesis remains largely unclear. We previously showed that mice deficient in mitogen‐ac
Publikováno v:
Nanomedicine (London, England). 15(24)
Aim: To establish a light-independent functionality of gold nanorods (AuNRs) with a human serum (HS) protein corona loaded with photosensitizer Chlorin e6 (AuNR-HS-Ce6) in M1 polarization of macrophages. Methods: RT-qPCR and ELISA were used to determ
Autor:
Yongliang Zhang, Heng Boon Low, Soon Boon Justin Wong, De Yun Wang, Chun-Wei Li, Chin Wen Png
Publikováno v:
Oncotarget
// Heng Boon Low 1, 2 , Chin Wen Png 1, 2 , Chunwei Li 3 , De Yun Wang 4 , Soon Boon Justin Wong 1, 2, 5 , Yongliang Zhang 1, 2 1 Department of Microbiology and Immunology, Yong Loo Lin School of Medicine, National University of Singapore, Singapore
Role of IL-13Rα2 in modulating IL-13-induced MUC5AC and ciliary changes in healthy and CRSwNP mucosa
Autor:
Kim Thye Thong, Kai Sen Tan, Jing Liu, De Yun Wang, Heng Boon Low, Yew Kwang Ong, Li Shi, Yingying Li, Yan Yan, Yongliang Zhang, Hsiao Hui Ong, Anand Kumar Andiappan, Feng Gang Yu
Publikováno v:
Allergy. 73(8)
Background The IL-13 receptor α2 (IL-13Rα2) is a receptor for IL-13 which has conflicting roles in mediating IL-13 responses in the lower airway, with little known about its impact on upper airway diseases. We sought to investigate the expression o
Autor:
Heng Boon Low, Yongliang Zhang
Publikováno v:
Immune Network
The mitogen-activated protein kinases (MAPKs) are key regulators of cell growth and survival in physiological and pathological processes. Aberrant MAPK signaling plays a critical role in the development and progression of human cancer, as well as in
Autor:
Grant D. Barry, Heng Boon Low, Bernadine M. Flanagan, Maria A. Halili, David P. Fairlie, Jacky Y. Suen, Bernhard Pfeiffer, Giang Thanh Le
Publikováno v:
Bioorganicmedicinal chemistry letters. 17(20)
Protease activated receptor 2 (PAR(2)) is a G protein-coupled receptor implicated in inflammation and cancer. Only a few peptide agonists are known with greater potency than the native agonist SLIGRL-NH(2). Here we report 52 peptide agonists of PAR(2