Zobrazeno 1 - 10
of 218
pro vyhledávání: '"Heng‐Yu Fan"'
Autor:
Hua Zhang, Yang Wang, Zhe‐Wei Hu, Yun‐Wen Wu, Nuo Chen, Yi‐Min Zhu, Yuan‐Song Yu, Heng‐Yu Fan, Hua‐Nan Wang
Publikováno v:
Advanced Science, Vol 11, Iss 14, Pp n/a-n/a (2024)
Abstract During maternal‐to‐zygotic transition (MZT) in the embryo, mRNA undergoes complex post‐transcriptional regulatory processes. However, it is unclear whether and how alternative splicing plays a functional role in MZT. By analyzing trans
Externí odkaz:
https://doaj.org/article/02c2221c503943b5a68487f1a72c2e2d
Autor:
Yu Jiang, Fei Huang, Lu Chen, Jia-Hui Gu, Yun-Wen Wu, Meng-Yan Jia, Zhen Lin, Yong Zhou, Yan-Chu Li, Chao Yu, Ming-Han Tong, Li Shen, Heng-Yu Fan, Qian-Qian Sha
Publikováno v:
Journal of Advanced Research, Vol 51, Iss , Pp 45-57 (2023)
Introduction: The R-loop is a naturally formed three-strand nucleic acid structure that recently has been reported to participate in multiple biological processes and helped answer some previously unexplained scientific questions. Meiosis process inv
Externí odkaz:
https://doaj.org/article/4890cde09fa8489fa86e42022bebe847
Autor:
Shuai-Shuai Wang, Xing-Feng Mao, Zhi-Shen Cai, Wen Lin, Xiu-Xiu Liu, Bei Luo, Xiang Chen, Yue Yue, Heng-Yu Fan, Takuya Sasaki, Kohji Fukunaga, Wen-Bin Zhang, Ying-Mei Lu, Feng Han
Publikováno v:
Research, Vol 7 (2024)
Cognitive dysfunction stands as a prevalent and consequential non-motor manifestation in Parkinson’s disease (PD). Although dysfunction of the olfactory system has been recognized as an important predictor of cognitive decline, the exact mechanism
Externí odkaz:
https://doaj.org/article/82347790038e42c8b7fa0e218adab4be
Autor:
Lucie Lamacova, Denisa Jansova, Zongliang Jiang, Michal Dvoran, Daria Aleshkina, Rajan Iyyappan, Anna Jindrova, Heng-Yu Fan, Yuxuan Jiao, Andrej Susor
Publikováno v:
Cells, Vol 13, Iss 10, p 850 (2024)
Mammalian oocyte development depends on the temporally controlled translation of maternal transcripts, particularly in the coordination of meiotic and early embryonic development when transcription has ceased. The translation of mRNA is regulated by
Externí odkaz:
https://doaj.org/article/f05763aed54e43a3bcfd06be831e41f9
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-15 (2022)
It is unclear how translational efficiency and codon stringency affect zygotic genome activation and early embryonic development. Here they show that the zygotic gene BZW1 increases start codon stringency, which is important for preimplantation devel
Externí odkaz:
https://doaj.org/article/b1f151c5f5904dd9b80610390a7f96b6
Autor:
Lingli Huang, Wenqing Li, Xingxing Dai, Shuai Zhao, Bo Xu, Fengsong Wang, Ren-Tao Jin, Lihua Luo, Limin Wu, Xue Jiang, Yu Cheng, Jiaqi Zou, Caoling Xu, Xianhong Tong, Heng-Yu Fan, Han Zhao, Jianqiang Bao
Publikováno v:
eLife, Vol 12 (2023)
Human oocyte maturation arrest represents one of the severe conditions for female patients with primary infertility. However, the genetic factors underlying this human disease remain largely unknown. The spindle assembly checkpoint (SAC) is an intric
Externí odkaz:
https://doaj.org/article/8365c3f5d7bd49dd9dfa2b8f34870dd3
Autor:
Yun-Wen Wu, Sen Li, Wei Zheng, Yan-Chu Li, Lu Chen, Yong Zhou, Zuo-Qi Deng, Ge Lin, Heng-Yu Fan, Qian-Qian Sha
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-17 (2022)
Developmental potential of oocytes decreases in women of advanced age. Here the authors observe impaired meiosis-coupled mRNA decay and reduced CXXC1-maintained histone H3K4 trimethylation in old oocytes of mouse and humans.
Externí odkaz:
https://doaj.org/article/1114e1c4fd5b427fa25c3b78e12ccf7f
Autor:
Yin‐Li Zhang, Wei Zheng, Peipei Ren, Huiling Hu, Xiaomei Tong, Shuo‐Ping Zhang, Xiang Li, Haichao Wang, Jun‐Chao Jiang, Jiamin Jin, Weijie Yang, Lanrui Cao, Yuanlin He, Yerong Ma, Yingyi Zhang, Yifan Gu, Liang Hu, Keli Luo, Fei Gong, Guang‐Xiu Lu, Ge Lin, Heng‐Yu Fan, Songying Zhang
Publikováno v:
EMBO Molecular Medicine, Vol 13, Iss 12, Pp 1-19 (2021)
Abstract Early embryonic arrest and fragmentation (EEAF) is a common phenomenon leading to female infertility, but the genetic determinants remain largely unknown. The Moloney sarcoma oncogene (MOS) encodes a serine/threonine kinase that activates th
Externí odkaz:
https://doaj.org/article/4c2cd6de5312404d872f47f428ad7192
Autor:
Qian-Qian Sha, Wei Zheng, Yun-Wen Wu, Sen Li, Lei Guo, Shuoping Zhang, Ge Lin, Xiang-Hong Ou, Heng-Yu Fan
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-16 (2020)
How maternal RNA clearance is regulated in human preimplantation embryos is unclear. Here, the authors show there is a potential correlation between maternal mRNA decay defects and early developmental arrest from in vitro fertilized human embryos, su
Externí odkaz:
https://doaj.org/article/e246ffb072c949edb55bfd5a4212656f
Autor:
Xing-Xing Dai, Zhi-Yan Jiang, Yun-Wen Wu, Qian-Qian Sha, Yang Liu, Jia-Yi Ding, Wen-Dong Xi, Jing Li, Heng-Yu Fan
Publikováno v:
Cell Reports, Vol 37, Iss 7, Pp 110007- (2021)
Summary: CCR4-NOT deadenylase is a major regulator of mRNA turnover. It contains two heterogeneous catalytic subunits CNOT7/8 and CNOT6/6L in vertebrates. The physiological function of each catalytic subunit is unclear due to the gene redundancy. In
Externí odkaz:
https://doaj.org/article/7804dcdc6b2041b8839bd5309aa88b29