Výsledky vyhledávání - "Heng‐Jie Cheng"

Akademický článek

Calmodulin-dependent protein kinase II activation promotes kidney mesangial expansion in streptozotocin-induced diabetic mice

Autor: Alexei V. Mikhailov, Yixi Liu, Heng-Jie Cheng, Jen-Jar Lin, Che Ping Cheng

Publikováno v: Heliyon, Vol 8, Iss 11, Pp e11653- (2022)

Calcium-calmodulin-dependent protein kinase II (CaMKII) is upregulated in diabetes mellitus (DM), leading to the overproduction of collagen in the myocardium. We hypothesized that CaMKII plays a role in the development of diabetic nephropathy (DN). S

Externí odkaz: https://doaj.org/article/adb3bb76858a4c08ac7bc8430969803e

Zobrazit plný text záznamu

Akademický článek

Increased CaMKII activation and contrast changes of cardiac β1-and β3-Adrenergic signaling pathways in a humanized angiotensinogen model of hypertension

Autor: Xiaoqiang Sun, Jing Cao, Zhe Chen, Yixi Liu, Jessica L. VonCannon, Heng Jie Cheng, Carlos M. Ferrario, Che Ping Cheng

Publikováno v: Heliyon, Vol 9, Iss 7, Pp e17851- (2023)

Aims: Upregulation of Ca2+/calmodulin-dependent protein kinase II (CaMKII) contributes to the pathogenesis of cardiovascular disease, including hypertension. Transgenic rats expressing the human angiotensinogen gene [TGR (hAGT)L1623] are a new novel

Externí odkaz: https://doaj.org/article/830f8fc8a989467d8a55f5682676329c

Zobrazit plný text záznamu

Chronic Ca2+/Calmodulin-Dependent Protein Kinase II Inhibition Rescues Advanced Heart Failure

Autor: Dalane W. Kitzman, Che Ping Cheng, Xiaowei Zhang, Qun Shao, Michael F. Callahan, Tiankai Li, Heng-Jie Cheng, Yixi Liu, David M. Herrington, David Zhao

Publikováno v: Journal of Pharmacology and Experimental Therapeutics. 377:316-325

Ca2+/calmodulin-dependent protein kinase II (CaMKII) is upregulated in congestive heart failure (CHF), contributing to electrical, structural, and functional remodeling. CaMKII inhibition is known to improve CHF, but its direct cardiac effects in CHF

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::fadb87cbc882726967fdb972fb40b1ae
https://doi.org/10.1124/jpet.120.000361

Zobrazit plný text záznamu

Reversal of angiotensin-(1–12)-caused positive modulation on left ventricular contractile performance in heart failure: Assessment by pressure-volume analysis

Autor: Tiankai Li, Sarfaraz Ahmad, Xiaowei Zhang, Zhe Chen, Zhi Zhang, Che Ping Cheng, Carlos M. Ferrario, Heng-Jie Cheng

Publikováno v: International Journal of Cardiology. 301:135-141

Background Angiotensin-(1–12) [Ang-(1–12)] is a renin-independent precursor for direct angiotensin-II production by chymase. Substantial evidence suggests that heart failure (HF) may alter cardiac Ang-(1–12) expression and activity; this novel

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ed8234ab5219208e689de02a4c0a1162
https://doi.org/10.1016/j.ijcard.2019.09.004

Zobrazit plný text záznamu

Calmodulin-dependent protein kinase II activation promotes kidney mesangial expansion in streptozotocin-induced diabetic mice

Autor: Alexei V. Mikhailov, Yixi Liu, Heng-Jie Cheng, Jen-Jar Lin, Che Ping Cheng

Publikováno v: Heliyon. 8(11)

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::565975fd334174d938f31eb80b89b77d
https://pubmed.ncbi.nlm.nih.gov/36411910

Zobrazit plný text záznamu

Abstract 13385: Protective Effect of Beta3-Adrenergic Receptor Deficiency on Diabetic Cardiomyopathy: Reversal of Type 2 Diabetes-Induced Contrast Changes of Cardiac SERCA 2a and Inducible Nitric Oxide Synthase

Autor: Xiaoqiang Sun, David Zhao, Che Cheng, Dalane W. Kitzman, Zhe Chen, Heng-Jie Cheng, Yixi Liu, Jing Cao

Publikováno v: Circulation. 142

Background: We have shown that diabetes (DM)-induced cardiac dysfunction and β-adrenergic desensitization were prevented in β 3 -adrenergic receptor (AR) knockout (β 3 KO) mice. However, the molecular mechanism is unclear. We hypothesize that reve

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::bd785e0b1df63e8fce3309211aff3eed
https://doi.org/10.1161/circ.142.suppl_3.13385

Zobrazit plný text záznamu

Abstract 13100: Rescue Myocardial Aging Caused a Progressive Decline in Cardiac Function and β-Adrenergic Reserve With a Selective Beta3-Adrenergic Receptor Antagonist, but Not Beta1-Adrenergic Receptor Blocker in a Murine Model

Autor: Heng-Jie Cheng, Dalane W. Kitzman, Jing Cao, Satoshi Masutani, Che Cheng, Xiaoqiang Sun, Peng Zhou, David Zhao, Zhe Chen, Yixi Liu

Publikováno v: Circulation. 142

Background: Cardiac aging (CA) leads to the progressive decline in cardiac function- increasing risk for heart failure (HF) and cardiac mortality. Both down-regulation of β 1 -adrenergic receptors (AR) and up-regulation of a newly-described inhibito

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::40c9051392b3803c73ea5dbd9831312b
https://doi.org/10.1161/circ.142.suppl_3.13100

Zobrazit plný text záznamu

Abstract 12692: Overexpression of Myocardial Inducible Nitric Oxide Synthase Exacerbates Cardiac Dysfunction and Beta-Adrenergic Desensitization in Streptozotocin-Induced Diabetic Mice

Autor: Dalane W. Kitzman, Jing Cao, Xiaoqiang Sun, Che Cheng, David Zhao, David M. Herrington, Peng Zhou, Heng-Jie Cheng, Yixi Liu

Publikováno v: Circulation. 142

Background: Recent evidence links impaired nitric oxide (NO) signaling pathway in the pathogenesis of diabetes-induced cardiac dysfunction. However, the different nitric oxide synthases (NOS) isoforms involved in this pathology are controversial. Rec

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::3303f058ee63fe43100401640076b0ce
https://doi.org/10.1161/circ.142.suppl_3.12692

Zobrazit plný text záznamu

Vyhledávací nástroje:

Upřesnit hledání