Intact nuclear membrane in necrotic keratinocytes of Stevens-Johnson syndrome distinguishes complement-mediated target cell lysis in ADCC from cytotoxic T-lymphocyte-mediated cytolysis

Autor: Allen, Sg, Heng, Hl

Publikováno v: Journal of Dermatological Treatment; 1993, Vol. 4 Issue: 2 p65-70, 6p

Integrative multiomics enhancer activity profiling identifies therapeutic vulnerabilities in cholangiocarcinoma of different etiologies.

Autor: Hong JH; Cancer and Stem Cell Biology Programme, Duke-NUS Medical School, Singapore., Yong CH; Laboratory of Cancer Epigenome, National Cancer Centre Singapore, Singapore.; Department of Computer Science, National University of Singapore, Singapore., Heng HL; Laboratory of Cancer Epigenome, National Cancer Centre Singapore, Singapore., Chan JY; Division of Medical Oncology, National Cancer Centre Singapore, Singapore.; Cancer Discovery Hub, National Cancer Centre Singapore, Singapore.; Oncology Academic Clinical Program, Duke-NUS Medical School, Singapore., Lau MC; Singapore Immunology Network, Agency for Science Technology and Research (A*STAR), Singapore.; Bioinformatics Institute (BII), Agency for Science Technology and Research (A*STAR), Singapore., Chen J; State Key Laboratory of Oncology in South China, Collaborative Innovation Center of Cancer Medicine, Sun Yat-sen University Cancer Center, Guangzhou, China., Lee JY; Laboratory of Cancer Epigenome, National Cancer Centre Singapore, Singapore.; Cancer Discovery Hub, National Cancer Centre Singapore, Singapore., Lim AH; Laboratory of Cancer Epigenome, National Cancer Centre Singapore, Singapore.; Cancer Discovery Hub, National Cancer Centre Singapore, Singapore., Li Z; Laboratory of Cancer Epigenome, National Cancer Centre Singapore, Singapore.; Cancer Discovery Hub, National Cancer Centre Singapore, Singapore., Guan P; Genome Institute of Singapore, Agency for Science Technology and Research (A*STAR), Singapore., Chu PL; Cancer and Stem Cell Biology Programme, Duke-NUS Medical School, Singapore., Boot A; Cancer and Stem Cell Biology Programme, Duke-NUS Medical School, Singapore.; Centre for Computational Biology, Duke-NUS Medical School, Singapore., Ng SR; Institute of Molecular and Cell Biology, Agency for Science Technology and Research (A*STAR), Singapore., Yao X; Institute of Molecular and Cell Biology, Agency for Science Technology and Research (A*STAR), Singapore., Wee FYT; Institute of Molecular and Cell Biology, Integrative Biology for Theranostics Lab, Agency for Science Technology and Research (A*STAR), Singapore., Lim JCT; Institute of Molecular and Cell Biology, Integrative Biology for Theranostics Lab, Agency for Science Technology and Research (A*STAR), Singapore., Liu W; Laboratory of Cancer Epigenome, National Cancer Centre Singapore, Singapore., Wang P; State Key Laboratory of Oncology in South China, Collaborative Innovation Center of Cancer Medicine, Sun Yat-sen University Cancer Center, Guangzhou, China., Xiao R; State Key Laboratory of Oncology in South China, Collaborative Innovation Center of Cancer Medicine, Sun Yat-sen University Cancer Center, Guangzhou, China., Zeng X; State Key Laboratory of Oncology in South China, Collaborative Innovation Center of Cancer Medicine, Sun Yat-sen University Cancer Center, Guangzhou, China., Sun Y; State Key Laboratory of Oncology in South China, Collaborative Innovation Center of Cancer Medicine, Sun Yat-sen University Cancer Center, Guangzhou, China., Koh J; Institute of Molecular and Cell Biology, Agency for Science Technology and Research (A*STAR), Singapore., Kwek XY; Laboratory of Cancer Epigenome, National Cancer Centre Singapore, Singapore., Ng CCY; Laboratory of Cancer Epigenome, National Cancer Centre Singapore, Singapore.; Cancer Discovery Hub, National Cancer Centre Singapore, Singapore., Klanrit P; Cholangiocarcinoma Screening and Care Program (CASCAP), Khon Kaen University, Khon Kaen, Thailand.; Department of Biochemistry, Faculty of Medicine, Khon Kaen University, Khon Kaen, Thailand., Zhang Y; State Key Laboratory of Oncology in South China, Collaborative Innovation Center of Cancer Medicine, Sun Yat-sen University Cancer Center, Guangzhou, China.; Department of Liver Surgery, Sun Yat-Sen University Cancer Center, Guangzhou, Guangdong., Lai J; Department of Pancreaticobiliary Surgery, Sun Yat-sen University, Guangzhou, China., Tai DWM; Division of Medical Oncology, National Cancer Centre Singapore, Singapore.; Oncology Academic Clinical Program, Duke-NUS Medical School, Singapore., Pairojkul C; Department of Pathology, Faculty of Medicine, Khon Kaen University, Khon Kaen, Thailand., Dima S; Center of Digestive Diseases and Liver Transplantation, Fundeni Clinical Institute, Bucuresti, Romania., Popescu I; Center of Digestive Diseases and Liver Transplantation, Fundeni Clinical Institute, Bucuresti, Romania., Hsieh SY; Department of Gastroenterology and Hepatology, Chang Gung Memorial Hospital and Chang Gung University, Taoyuan, Taiwan., Yu MC; Department of General Surgery, Chang Gung Memorial Hospital and Chang Gung University, Taoyuan, Taiwan., Yeong J; Institute of Molecular and Cell Biology, Integrative Biology for Theranostics Lab, Agency for Science Technology and Research (A*STAR), Singapore.; Department of Anatomical Pathology, Singapore General Hospital, Singapore.; Pathology Academic Clinical Program, Duke-NUS Medical School, Singapore., Kongpetch S; Cholangiocarcinoma Research Institute, Khon Kaen University, Khon Kaen, Thailand.; Department of Pharmacology, Faculty of Medicine, Khon Kaen University, Khon Kaen, Thailand., Jusakul A; Cholangiocarcinoma Research Institute, Khon Kaen University, Khon Kaen, Thailand.; Centre for Research and Development of Medical Diagnostic Laboratories, Faculty of Associated Medical Sciences, Khon Kaen University, Khon Kaen, Thailand., Loilome W; Cholangiocarcinoma Screening and Care Program (CASCAP), Khon Kaen University, Khon Kaen, Thailand.; Department of Biochemistry, Faculty of Medicine, Khon Kaen University, Khon Kaen, Thailand.; Cholangiocarcinoma Research Institute, Khon Kaen University, Khon Kaen, Thailand., Tan P; Cancer and Stem Cell Biology Programme, Duke-NUS Medical School, Singapore.; Genome Institute of Singapore, Agency for Science Technology and Research (A*STAR), Singapore.; Cancer Science Institute of Singapore, National University of Singapore, Singapore., Tan J; Laboratory of Cancer Epigenome, National Cancer Centre Singapore, Singapore.; State Key Laboratory of Oncology, Collaborative Innovation Center of Cancer Medicine, Sun Yat-sen University Cancer Center, Guangzhou, China., Teh BT; Cancer and Stem Cell Biology Programme, Duke-NUS Medical School, Singapore teh.bin.tean@singhealth.com.sg.; Laboratory of Cancer Epigenome, National Cancer Centre Singapore, Singapore.; Genome Institute of Singapore, Agency for Science Technology and Research (A*STAR), Singapore.; Institute of Molecular and Cell Biology, Agency for Science Technology and Research (A*STAR), Singapore.

Publikováno v: Gut [Gut] 2024 May 10; Vol. 73 (6), pp. 966-984. Date of Electronic Publication: 2024 May 10.

PBRM1-deficient PBAF complexes target aberrant genomic loci to activate the NF-κB pathway in clear cell renal cell carcinoma.

Autor: Yao X; Institute of Molecular and Cell Biology, Agency for Science, Technology and Research (A*STAR), Singapore, Republic of Singapore. yao.xiaosai@gene.com.; Department of Molecular Oncology, Genentech, South San Francisco, CA, USA. yao.xiaosai@gene.com., Hong JH; Duke-NUS Medical School, Singapore, Republic of Singapore., Nargund AM; Duke-NUS Medical School, Singapore, Republic of Singapore., Ng MSW; Institute of Molecular and Cell Biology, Agency for Science, Technology and Research (A*STAR), Singapore, Republic of Singapore., Heng HL; National Cancer Centre Singapore, Singapore, Republic of Singapore., Li Z; National Cancer Centre Singapore, Singapore, Republic of Singapore., Guan P; Genome Institute of Singapore, Agency for Science, Technology and Research (A*STAR), Singapore, Republic of Singapore., Sugiura M; Department of Pathology and Laboratory Medicine, KK Women's and Children's Hospital, Singapore, Republic of Singapore., Chu PL; Duke-NUS Medical School, Singapore, Republic of Singapore., Wang LC; Institute of Molecular and Cell Biology, Agency for Science, Technology and Research (A*STAR), Singapore, Republic of Singapore.; SingMass - National Mass Spectrometry Laboratory, Institute of Molecular and Cell Biology, Agency for Science, Technology and Research (A*STAR), Singapore, Republic of Singapore.; Functional Proteomics Laboratory, Institute of Molecular and Cell Biology, Agency for Science, Technology and Research (A*STAR), Singapore, Republic of Singapore., Ye X; Department of Molecular Oncology, Genentech, South San Francisco, CA, USA., Qu J; Genome Institute of Singapore, Agency for Science, Technology and Research (A*STAR), Singapore, Republic of Singapore., Kwek XY; Department of Pathology and Laboratory Medicine, KK Women's and Children's Hospital, Singapore, Republic of Singapore., Lim JCT; Institute of Molecular and Cell Biology, Agency for Science, Technology and Research (A*STAR), Singapore, Republic of Singapore., Ooi WF; Genome Institute of Singapore, Agency for Science, Technology and Research (A*STAR), Singapore, Republic of Singapore., Koh J; National Cancer Centre Singapore, Singapore, Republic of Singapore., Wang Z; Duke-NUS Medical School, Singapore, Republic of Singapore.; Genome Institute of Singapore, Agency for Science, Technology and Research (A*STAR), Singapore, Republic of Singapore., Pan YF; National Cancer Centre Singapore, Singapore, Republic of Singapore.; Department of Medical Genetics, Zunyi Medical University, Zunyi, China., Ong YS; Institute of Molecular and Cell Biology, Agency for Science, Technology and Research (A*STAR), Singapore, Republic of Singapore., Tan KY; Institute of Molecular and Cell Biology, Agency for Science, Technology and Research (A*STAR), Singapore, Republic of Singapore.; SingMass - National Mass Spectrometry Laboratory, Institute of Molecular and Cell Biology, Agency for Science, Technology and Research (A*STAR), Singapore, Republic of Singapore.; Functional Proteomics Laboratory, Institute of Molecular and Cell Biology, Agency for Science, Technology and Research (A*STAR), Singapore, Republic of Singapore., Goh JY; Duke-NUS Medical School, Singapore, Republic of Singapore.; Department of Pathology and Laboratory Medicine, KK Women's and Children's Hospital, Singapore, Republic of Singapore., Ng SR; Institute of Molecular and Cell Biology, Agency for Science, Technology and Research (A*STAR), Singapore, Republic of Singapore., Pignata L; Institute of Molecular and Cell Biology, Agency for Science, Technology and Research (A*STAR), Singapore, Republic of Singapore.; Department of Biochemistry, Yong Loo Lin School of Medicine, National University of Singapore, Singapore, Republic of Singapore., Huang D; National Cancer Centre Singapore, Singapore, Republic of Singapore., Lezhava A; Genome Institute of Singapore, Agency for Science, Technology and Research (A*STAR), Singapore, Republic of Singapore., Tay ST; Duke-NUS Medical School, Singapore, Republic of Singapore., Lee M; Duke-NUS Medical School, Singapore, Republic of Singapore., Yeo XH; Genome Institute of Singapore, Agency for Science, Technology and Research (A*STAR), Singapore, Republic of Singapore., Tam WL; Genome Institute of Singapore, Agency for Science, Technology and Research (A*STAR), Singapore, Republic of Singapore.; Department of Biochemistry, Yong Loo Lin School of Medicine, National University of Singapore, Singapore, Republic of Singapore.; Cancer Science Institute of Singapore, National University of Singapore, Singapore, Republic of Singapore.; School of Biological Sciences, Nanyang Technological University, Singapore, Republic of Singapore., Rha SY; Division of Medical Oncology, Yonsei Cancer Center, Yonsei University Health System, Seoul, Republic of Korea., Li S; Duke-NUS Medical School, Singapore, Republic of Singapore., Guccione E; Center for Therapeutics Discovery, Department of Oncological Sciences and Pharmacological Sciences, Tisch Cancer Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA., Futreal A; Department of Genomic Medicine, UT MD Anderson Cancer Center, Houston, TX, USA., Tan J; Sun Yat-sen University Cancer Center, Guangzhou, China., Yeong JPS; Institute of Molecular and Cell Biology, Agency for Science, Technology and Research (A*STAR), Singapore, Republic of Singapore., Hong W; Institute of Molecular and Cell Biology, Agency for Science, Technology and Research (A*STAR), Singapore, Republic of Singapore., Yauch R; Department of Molecular Oncology, Genentech, South San Francisco, CA, USA., Chang KT; Duke-NUS Medical School, Singapore, Republic of Singapore.; Department of Pathology and Laboratory Medicine, KK Women's and Children's Hospital, Singapore, Republic of Singapore., Sobota RM; Institute of Molecular and Cell Biology, Agency for Science, Technology and Research (A*STAR), Singapore, Republic of Singapore.; SingMass - National Mass Spectrometry Laboratory, Institute of Molecular and Cell Biology, Agency for Science, Technology and Research (A*STAR), Singapore, Republic of Singapore.; Functional Proteomics Laboratory, Institute of Molecular and Cell Biology, Agency for Science, Technology and Research (A*STAR), Singapore, Republic of Singapore., Tan P; Duke-NUS Medical School, Singapore, Republic of Singapore.; Genome Institute of Singapore, Agency for Science, Technology and Research (A*STAR), Singapore, Republic of Singapore.; Cancer Science Institute of Singapore, National University of Singapore, Singapore, Republic of Singapore., Teh BT; Institute of Molecular and Cell Biology, Agency for Science, Technology and Research (A*STAR), Singapore, Republic of Singapore. teh.bin.tean@singhealth.com.sg.; Duke-NUS Medical School, Singapore, Republic of Singapore. teh.bin.tean@singhealth.com.sg.; National Cancer Centre Singapore, Singapore, Republic of Singapore. teh.bin.tean@singhealth.com.sg.; Genome Institute of Singapore, Agency for Science, Technology and Research (A*STAR), Singapore, Republic of Singapore. teh.bin.tean@singhealth.com.sg.

Publikováno v: Nature cell biology [Nat Cell Biol] 2023 May; Vol. 25 (5), pp. 765-777. Date of Electronic Publication: 2023 Apr 24.

Functional characterisation guides classification of novel BAP1 germline variants.

Autor: Hong JH; Cancer and Stem Cell Biology Program, Duke-NUS Medical School, Singapore, 169857 Singapore.; Institute of Molecular and Cellular Biology, Agency for Science, Technology and Research, Singapore, 138673 Singapore., Chong ST; Cancer Genetics Service, Division of Medical Oncology, National Cancer Center, Singapore, 169610 Singapore., Lee PH; Cancer Science Institute of Singapore, National University of Singapore, Singapore, 117599 Singapore.; Genome Institute of Singapore, Agency for Science, Technology and Research, Singapore, 138672 Singapore., Tan J; Sun Yat-sen University Cancer Center, State Key Laboratory of Oncology in South China, Collaborative Innovation Center of Cancer Medicine, 510060 Guangzhou, Guangdong China.; Laboratory of Cancer Epigenome, Division of Medical Sciences, National Cancer Centre Singapore, Singapore, 169610 Singapore., Heng HL; Cancer and Stem Cell Biology Program, Duke-NUS Medical School, Singapore, 169857 Singapore.; Laboratory of Cancer Epigenome, Division of Medical Sciences, National Cancer Centre Singapore, Singapore, 169610 Singapore., Ishak NDB; Cancer Genetics Service, Division of Medical Oncology, National Cancer Center, Singapore, 169610 Singapore., Chan SH; Cancer Genetics Service, Division of Medical Oncology, National Cancer Center, Singapore, 169610 Singapore., Teh BT; Cancer and Stem Cell Biology Program, Duke-NUS Medical School, Singapore, 169857 Singapore.; Institute of Molecular and Cellular Biology, Agency for Science, Technology and Research, Singapore, 138673 Singapore.; Cancer Science Institute of Singapore, National University of Singapore, Singapore, 117599 Singapore.; Genome Institute of Singapore, Agency for Science, Technology and Research, Singapore, 138672 Singapore.; Laboratory of Cancer Epigenome, Division of Medical Sciences, National Cancer Centre Singapore, Singapore, 169610 Singapore.; SingHealth/Duke-NUS Institute of Precision Medicine, National Heart Centre, Singapore, Singapore., Ngeow J; Institute of Molecular and Cellular Biology, Agency for Science, Technology and Research, Singapore, 138673 Singapore.; Cancer Genetics Service, Division of Medical Oncology, National Cancer Center, Singapore, 169610 Singapore.; Lee Kong Chian School of Medicine, Nanyang Technological University, Singapore, 308232 Singapore.; Oncology Academic Clinical Program, Duke-NUS Medical School, Singapore, 169857 Singapore.

Publikováno v: NPJ genomic medicine [NPJ Genom Med] 2020 Nov 19; Vol. 5, pp. 50. Date of Electronic Publication: 2020 Nov 19 (Print Publication: 2020).

Correction: Synthesis and evaluation of nuciferine and roemerine enantiomers as 5-HT 2 and α 1 receptor antagonists.

Autor: Heng HL; Department of Pharmacy , Faculty of Medicine , University of Malaya , 50603 Kuala Lumpur , Malaysia . Email: buckle@um.edu.my ; Email: chungly@um.edu.my ; ; Tel: +60 3 79674959., Chee CF; Department of Pharmacy , Faculty of Medicine , University of Malaya , 50603 Kuala Lumpur , Malaysia . Email: buckle@um.edu.my ; Email: chungly@um.edu.my ; ; Tel: +60 3 79674959.; Department of Chemistry , Faculty of Science , University of Malaya , 50603 Kuala Lumpur , Malaysia., Chin SP; Department of Pharmacy , Faculty of Medicine , University of Malaya , 50603 Kuala Lumpur , Malaysia . Email: buckle@um.edu.my ; Email: chungly@um.edu.my ; ; Tel: +60 3 79674959.; Department of Chemistry , Faculty of Science , University of Malaya , 50603 Kuala Lumpur , Malaysia., Ouyang Y; School of Pharmacy , Ningxia Medical University , Yinchuan , 750004 , P. R. China., Wang H; School of Pharmacy , Ningxia Medical University , Yinchuan , 750004 , P. R. China., Buckle MJC; Department of Pharmacy , Faculty of Medicine , University of Malaya , 50603 Kuala Lumpur , Malaysia . Email: buckle@um.edu.my ; Email: chungly@um.edu.my ; ; Tel: +60 3 79674959., Herr DR; Department of Pharmacology , Yong Loo Lin School of Medicine , National University of Singapore , 117597 , Singapore., Paterson IC; Department of Oral Biology and Craniofacial Sciences and Oral Cancer Research and Coordinating Centre , Faculty of Dentistry , University of Malaya , 50603 Kuala Lumpur , Malaysia., Doughty SW; Penang Medical College , 4 Jalan Sepoy Lines , 10450 George Town , Pulau Pinang , Malaysia., Abd Rahman N; Department of Chemistry , Faculty of Science , University of Malaya , 50603 Kuala Lumpur , Malaysia., Chung LY; Department of Pharmacy , Faculty of Medicine , University of Malaya , 50603 Kuala Lumpur , Malaysia . Email: buckle@um.edu.my ; Email: chungly@um.edu.my ; ; Tel: +60 3 79674959.

Publikováno v: MedChemComm [Medchemcomm] 2018 Mar 07; Vol. 9 (3), pp. 593-594. Date of Electronic Publication: 2018 Mar 07 (Print Publication: 2018).