Zobrazeno 1 - 10
of 20
pro vyhledávání: '"Hendrikus-Jan Dubbink"'
Autor:
Anyue Yin, G. D. Marijn Veerman, Johan G. C. vanHasselt, Christi M. J. Steendam, Hendrikus Jan Dubbink, Henk‐Jan Guchelaar, Lena E. Friberg, Anne‐Marie C. Dingemans, Ron H. J. Mathijssen, Dirk Jan A. R. Moes
Publikováno v:
CPT: Pharmacometrics & Systems Pharmacology, Vol 13, Iss 4, Pp 612-623 (2024)
Abstract Insight into the development of treatment resistance can support the optimization of anticancer treatments. This study aims to characterize the tumor dynamics and development of drug resistance in patients with non‐small cell lung cancer t
Externí odkaz:
https://doaj.org/article/ea749281c095497bbf69f8fe06f78a32
Autor:
Susanne R Bruekner, Wietske Pieters, Alexander Fish, A Manuel Liaci, Serge Scheffers, Emily Rayner, Daphne Kaldenbach, Lisa Drost, Marleen Dekker, Sandrine van Hees-Stuivenberg, Elly Delzenne-Goette, Charlotte de Konink, Hellen Houlleberghs, Hendrikus Jan Dubbink, Abeer AlSaegh, Niels de Wind, Friedrich Förster, Hein te Riele, Titia K Sixma
Publikováno v:
Nucleic Acids Research, 51(3), 1173-1188. Oxford University Press
Bruekner, S R, Pieters, W, Fish, A, Liaci, A M, Scheffers, S, Rayner, E, Kaldenbach, D, Drost, L, Dekker, M, van Hees-Stuivenberg, S, Delzenne-Goette, E, de Konink, C, Houlleberghs, H, Dubbink, H J, Alsaegh, A, de Wind, N, Förster, F, te Riele, H & Sixma, T K 2023, ' Unexpected moves : a conformational change in MutSα enables high-affinity DNA mismatch binding ', Nucleic Acids Research, vol. 51, no. 3, pp. 1173-1188 . https://doi.org/10.1093/nar/gkad015
Bruekner, S R, Pieters, W, Fish, A, Liaci, A M, Scheffers, S, Rayner, E, Kaldenbach, D, Drost, L, Dekker, M, van Hees-Stuivenberg, S, Delzenne-Goette, E, de Konink, C, Houlleberghs, H, Dubbink, H J, Alsaegh, A, de Wind, N, Förster, F, te Riele, H & Sixma, T K 2023, ' Unexpected moves : a conformational change in MutSα enables high-affinity DNA mismatch binding ', Nucleic Acids Research, vol. 51, no. 3, pp. 1173-1188 . https://doi.org/10.1093/nar/gkad015
The DNA mismatch repair protein MutSα recognizes wrongly incorporated DNA bases and initiates their correction during DNA replication. Dysfunctions in mismatch repair lead to a predisposition to cancer. Here, we study the homozygous mutation V63E in
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b261243e65c36c88dc6a5fefdea17ff9
https://doi.org/10.1093/nar/gkad015
https://doi.org/10.1093/nar/gkad015
Autor:
Dik C. van Gent, Agnes Jager, John W.M. Martens, Roland Kanaar, Harmen J.G. van de Werken, Marcel Smid, Petra M. Nederlof, Esther Lips, Winand N.M. Dinjens, T. Dorine den Toom, Hendrikus-Jan Dubbink, Hein F.B.M. Sleddens, Michael A. den Bakker, Carolien H.M. van Deurzen, Kishan A.T. Naipal, Job van Riet, Anieta M. Sieuwerts, Nicole S. Verkaik, Titia G. Meijer
BRCA1 promoter hypermethylation and RNA in situ hybridization by RNAscope. M248, M253, M112 and M232 clearly showed presence of BRCA1 RNA, whereas in M94 (BRCA1 deletion) no BRCA1 RNA was present. M131 and M277 showed heterogeneous presence of BRCA1
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2827c3e4bd4d34908bd75437d10a77c8
https://doi.org/10.1158/1078-0432.22467974
https://doi.org/10.1158/1078-0432.22467974
Autor:
Dik C. van Gent, Agnes Jager, John W.M. Martens, Roland Kanaar, Harmen J.G. van de Werken, Marcel Smid, Petra M. Nederlof, Esther Lips, Winand N.M. Dinjens, T. Dorine den Toom, Hendrikus-Jan Dubbink, Hein F.B.M. Sleddens, Michael A. den Bakker, Carolien H.M. van Deurzen, Kishan A.T. Naipal, Job van Riet, Anieta M. Sieuwerts, Nicole S. Verkaik, Titia G. Meijer
Supplemental legend
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2844bf2940ef6a51fe1e222feac5900e
https://doi.org/10.1158/1078-0432.22467965
https://doi.org/10.1158/1078-0432.22467965
Autor:
Dik C. van Gent, Agnes Jager, John W.M. Martens, Roland Kanaar, Harmen J.G. van de Werken, Marcel Smid, Petra M. Nederlof, Esther Lips, Winand N.M. Dinjens, T. Dorine den Toom, Hendrikus-Jan Dubbink, Hein F.B.M. Sleddens, Michael A. den Bakker, Carolien H.M. van Deurzen, Kishan A.T. Naipal, Job van Riet, Anieta M. Sieuwerts, Nicole S. Verkaik, Titia G. Meijer
Supplemental table 1: Comparison of clinicopathologic characteristics between successful tests and not successful tests. Supplemental table 2: Comparison of clinicopathologic characteristics RECAP positive/negative/intermediate tumors. Supplemental t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4fe6af393300d761a84d1449548ba895
https://doi.org/10.1158/1078-0432.22467962.v1
https://doi.org/10.1158/1078-0432.22467962.v1
Autor:
Dik C. van Gent, Agnes Jager, John W.M. Martens, Roland Kanaar, Harmen J.G. van de Werken, Marcel Smid, Petra M. Nederlof, Esther Lips, Winand N.M. Dinjens, T. Dorine den Toom, Hendrikus-Jan Dubbink, Hein F.B.M. Sleddens, Michael A. den Bakker, Carolien H.M. van Deurzen, Kishan A.T. Naipal, Job van Riet, Anieta M. Sieuwerts, Nicole S. Verkaik, Titia G. Meijer
Purpose:Tumors of germline BRCA1/2 mutated carriers show homologous recombination (HR) deficiency (HRD), resulting in impaired DNA double-strand break (DSB) repair and high sensitivity to PARP inhibitors. Although this therapy is expected to be effec
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::00bd8838bf937fd7d648e96993a8d148
https://doi.org/10.1158/1078-0432.c.6526802.v1
https://doi.org/10.1158/1078-0432.c.6526802.v1
Autor:
Silvia R. Vitale, Floris H. Groenendijk, Ronald van Marion, Corine M. Beaufort, Jean C. Helmijr, Hendrikus Jan Dubbink, Winand N. M. Dinjens, Patricia C. Ewing-Graham, Ramon Smolders, Helena C. van Doorn, Ingrid A. Boere, Els M. J. J. Berns, Jozien Helleman, Maurice P. H. M. Jansen
Publikováno v:
Biomolecules, Vol 10, Iss 3, p 415 (2020)
The aim of this study was to determine an optimal workflow to detect TP53 mutations in baseline and longitudinal serum cell free DNA (cfDNA) from high-grade serous ovarian carcinomas (HGSOC) patients and to define whether TP53 mutations are suitable
Externí odkaz:
https://doaj.org/article/76c9e3e5ee1348d4b952b7c5f009f099
Autor:
J.P. Van Kooten, Michelle Dietz, Hendrikus-Jan Dubbink, Cornelis Verhoef, Joachim Aerts, Eva Madsen, Jan von der Thüsen
Publikováno v:
European Journal of Surgical Oncology. 49:e200-e201
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::69147a31b800f00f4b8ba08539978ed0
https://doi.org/10.1016/j.ejso.2022.11.551
https://doi.org/10.1016/j.ejso.2022.11.551
Autor:
Michelle Dietz, Job van Kooten, Joachim Aerts, Cornelis Verhoef, Hendrikus Jan Dubbink, Eva Madsen, Jan von der Thüsen
Publikováno v:
European Journal of Surgical Oncology. 49:e193
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::bf1a3ad174a3ad2d126c3a8bdc4b39e6
https://doi.org/10.1016/j.ejso.2022.11.534
https://doi.org/10.1016/j.ejso.2022.11.534
Publikováno v:
Journal of thoracic oncology : official publication of the International Association for the Study of Lung Cancer. 16(7)
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::da51e561f7e5a5e6838da3ce9a0ac1df
https://pubmed.ncbi.nlm.nih.gov/34154792
https://pubmed.ncbi.nlm.nih.gov/34154792