Zobrazeno 1 - 10
of 89
pro vyhledávání: '"Hendrikus H, Boersma"'
Autor:
Hendrikus H. Boersma, Mirte M. Woerdenbag, Sascha Mulder, Tirza W. T. Poiesz, Lucas B. S. Bekhof, Hein T. Tholen, Gert Luurtsema, Marjolijn N. Lub-de Hooge, Danique Giesen, Herman J. Woerdenbag
Publikováno v:
Hygiene, Vol 4, Iss 3, Pp 282-296 (2024)
Environmental monitoring (EM) is the cornerstone for the assurance of sterility during aseptic manufacturing. In this study, the EM quality aspects in the radiopharmaceutical cleanrooms of the University Medical Center Groningen (UMCG), The Netherlan
Externí odkaz:
https://doaj.org/article/8ae27a52bf2c40e99b9f42bb72380081
Autor:
Ilse M. Welleman, Carlijn L. F. vanBeek, Ioana Belcin, Albert M. Schulte, Rudi A. J. O. Dierckx, Ben L. Feringa, Hendrikus H. Boersma, Wiktor Szymański
Publikováno v:
Smart Molecules, Vol 2, Iss 2, Pp n/a-n/a (2024)
Abstract In recent years, the use of light to selectively and precisely activate drugs has been developed along the fundamental concepts of photopharmacology. One of the key methods in this field relies on transiently silencing the drug activity with
Externí odkaz:
https://doaj.org/article/887ca37dba4d4b718855707bb232936d
Autor:
David G. Alleva, Eline A. Feitsma, Yester F. Janssen, Hendrikus H. Boersma, Thomas M. Lancaster, Thillainaygam Sathiyaseelan, Sylaja Murikipudi, Andrea R. Delpero, Melanie M. Scully, Ramya Ragupathy, Sravya Kotha, Jeffrey R. Haworth, Nishit J. Shah, Vidhya Rao, Shashikant Nagre, Shannon E. Ronca, Freedom M. Green, Stephen A. Shaw, Ari Aminetzah, Schelto Kruijff, Maarten Brom, Gooitzen M. van Dam, Todd C. Zion
Publikováno v:
npj Vaccines, Vol 9, Iss 1, Pp 1-12 (2024)
Abstract AKS-452, a subunit vaccine comprising an Fc fusion of the ancestral wild-type (WT) SARS-CoV-2 virus spike protein receptor binding domain (SP/RBD), was evaluated without adjuvant in a single cohort, non-randomized, open-labelled phase II stu
Externí odkaz:
https://doaj.org/article/3e169ceb8cc4445682f02ab1847c3f9e
Autor:
Jürgen W. A. Sijbesma, Aren van Waarde, Sebastiaan Kristensen, Ilse Kion, Uwe J. F. Tietge, Jan-Luuk Hillebrands, Marian L. C. Bulthuis, Hendrik Buikema, Dalibor Nakladal, Marit Westerterp, Fan Liu, Hendrikus H. Boersma, Rudi A. J. O. Dierckx, Riemer H. J. A. Slart
Publikováno v:
EJNMMI Research, Vol 13, Iss 1, Pp 1-14 (2023)
Abstract Background The apolipoprotein E-deficient (apoE −/− ) mouse is a well-established model for studying atherosclerosis. However, its small size limits its use in longitudinal positron emission tomography (PET) imaging studies. Recently, th
Externí odkaz:
https://doaj.org/article/e815cbc78a3e4fae8f600fd68f64930c
Autor:
Lisanne M. Braams, Jürgen W.A. Sijbesma, Hendrikus H. Boersma, Jan Maarten van Dijl, Philip H. Elsinga, Andor W.J.M. Glaudemans, Riemer H.J.A. Slart, Marleen van Oosten
Publikováno v:
International Journal of Medical Microbiology, Vol 313, Iss 3, Pp 151581- (2023)
Fluorine-18-fluorodeoxyglucose ([18F]FDG) positron emission tomography (18F-FDG-PET) is widely used for the detection of inflammatory and infectious diseases. Although this modality has proven to be a useful diagnostic tool, reliable distinction of b
Externí odkaz:
https://doaj.org/article/c4c9fbbf05214261aaeffe49ed2a1950
Autor:
Ilse M. Welleman, Friederike Reeβing, Hendrikus H. Boersma, Rudi A. J. O. Dierckx, Ben L. Feringa, Wiktor Szymanski
Publikováno v:
Pharmaceuticals, Vol 16, Iss 10, p 1439 (2023)
The molecular imaging of biomarkers plays an increasing role in medical diagnostics. In particular, the imaging of enzyme activity is a promising approach, as it enables the use of its inherent catalytic activity for the amplification of an imaging s
Externí odkaz:
https://doaj.org/article/80846890f5a74183b90930c62f822cc9
Autor:
Lydian A. Huisman, Pieter J. Steinkamp, Jan-Luuk Hillebrands, Clark J. Zeebregts, Matthijs D. Linssen, Annelies Jorritsma-Smit, Riemer H. J. A. Slart, Gooitzen M. van Dam, Hendrikus H. Boersma
Publikováno v:
Scientific Reports, Vol 11, Iss 1, Pp 1-11 (2021)
Abstract Vascular endothelial growth factor-A (VEGF-A) is assumed to play a crucial role in the development and rupture of vulnerable plaques in the atherosclerotic process. We used a VEGF-A targeted fluorescent antibody (bevacizumab-IRDye800CW [beva
Externí odkaz:
https://doaj.org/article/90bcd3fa4abc46a1b524b9280ad22262
Clinical-grade N-(4-[18F]fluorobenzoyl)-interleukin-2 for PET imaging of activated T-cells in humans
Autor:
Elly L. van der Veen, Inês F. Antunes, Petra Maarsingh, Janet Hessels-Scheper, Rolf Zijlma, Hendrikus H. Boersma, Annelies Jorritsma-Smit, Geke A. P. Hospers, Elisabeth G. E. de Vries, Marjolijn N. Lub-de Hooge, Erik F. J. de Vries
Publikováno v:
EJNMMI Radiopharmacy and Chemistry, Vol 4, Iss 1, Pp 1-15 (2019)
Abstract Background Molecular imaging of immune cells might be a potential tool for response prediction, treatment evaluation and patient selection in inflammatory diseases as well as oncology. Targeting interleukin-2 (IL2) receptors on activated T-c
Externí odkaz:
https://doaj.org/article/7a57832b88154ee490038dee2bfc7c47
Autor:
Pieter J. Steinkamp, Jasper Vonk, Lydian A. Huisman, Gert-Jan Meersma, Gilles F. H. Diercks, Jan-Luuk Hillebrands, Wouter B. Nagengast, Clark J. Zeebregts, Riemer H. J. A. Slart, Hendrikus H. Boersma, Gooitzen M. van Dam
Publikováno v:
Diagnostics, Vol 11, Iss 7, p 1227 (2021)
Vulnerable atherosclerotic carotid plaques are prone to rupture, resulting in ischemic strokes. In contrast to radiological imaging techniques, molecular imaging techniques have the potential to assess plaque vulnerability by visualizing diseases-spe
Externí odkaz:
https://doaj.org/article/e33eef6a0e1b4b2f836c4d029b67d2a7
Autor:
Marjolein Heuker, Jürgen W. A. Sijbesma, Rocío Aguilar Suárez, Johan R. de Jong, Hendrikus H. Boersma, Gert Luurtsema, Philip H. Elsinga, Andor W. J. M. Glaudemans, Gooitzen M. van Dam, Jan Maarten van Dijl, Riemer H. J. A. Slart, Marleen van Oosten
Publikováno v:
Scientific Reports, Vol 7, Iss 1, Pp 1-9 (2017)
Abstract Positron emission tomography (PET) with fluorine-18-fluorodeoxyglucose (18F-FDG) can be applied to detect infection and inflammation. However, it was so far not known to what extent bacterial pathogens may contribute to the PET signal. There
Externí odkaz:
https://doaj.org/article/264fc062fe304185807c54321efd1f2d