Výsledky vyhledávání - "Hendrikse, NH"

New positron emission tomography tracer [C-11]carvedilol reveals P-glycoprotein modulation kinetics

Autor: Bart, J, Dijkers, ECF, Wegman, TD, de Vries, EGE, van der Graaf, WTA, Groen, HJM, Vaalburg, W, Willemsen, ATM, Hendrikse, NH

Publikováno v: British Journal of Pharmacology, 145(8), 1045-1051. Wiley-Blackwell

1 Imaging of P-glycoprotein (P-gp) function in the blood-brain barrier (BBB) may support evelopment of strategies, which will improve drug delivery to the brain. [C-11] verapamil has been developed as a positron emission tomography ( PET) tracer, to

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=narcis______::d1ee0251be52a3c98c7e6a021a3ebb39
https://research.rug.nl/en/publications/ecace5d9-5f6d-47fa-aa1e-a502b57eaec6

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A new in vivo method to study P-glycoprotein transport in tumors and the blood-brain barrier

Autor: Hendrikse, NH, de Vries, EGE, Eriks-Fluks, L, van der Graaf, WTA, Hospers, GAP, Willemsen, ATM, Vaalburg, W, Franssen, EJF

Publikováno v: Cancer Research, 59(10), 2411-2416. AMER ASSOC CANCER RESEARCH

Drug resistance is a major cause of chemotherapy failure in cancer treatment, One reason is the overexpression of the drug efflux pump P-glycoprotein (P-gp), involved in multidrug resistance (MDR), In vivo pharmacokinetic analysis of P-gp transport m

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=narcis______::0ceb937b4c85fca70a825d93cf90f668
https://research.rug.nl/en/publications/28050621-ffa6-4f3a-a4a9-41965440bdaf

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Complete in vivo reversal of P-glycoprotein pump function in the blood-brain barrier visualized with positron emission tomography

Autor: Hendrikse, NH, Schinkel, AH, De Vries, EGE, Fluks, E, Van der Graaf, WTA, Willemsen, ATM, Vaalburg, W, Franssen, EJF

Publikováno v: British Journal of Pharmacology, 124(7), 1413-1418. Wiley-Blackwell

1 Homozygously mdr1a gene disrupted mice (mdr1a(-/-) mice) and wild type mice (mdr1a(+/+) mice) were used to develop a method for P-glycoprotein (P-gp) function imaging non-invasively and to study the effect of a P-gp reversal agent on its function i

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=narcis______::080f029061624e863b8119936a5a0151
https://research.rug.nl/en/publications/c65f61ef-23f5-4275-b6d2-8e3e1c00d7ba

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Enzymatic synthesis of [4-methoxy-C-11]daunorubicin for functional imaging of P-glycoprotein with PET

Autor: Eriks-Fluks, E, Elsinga, PH, Hendrikse, NH, Franssen, EJF, Vaalburg, W

Publikováno v: Applied Radiation and Isotopes, 49(7), 811-813. PERGAMON-ELSEVIER SCIENCE LTD

One of the mechanisms for multidrug resistance (MDR) of tumors is an overexpression of the P-glycoprotein (P-gp). The cytostatic agent daunorubicin was labeled with carbon-11 to probe P-gp with PET. An enzymatic route for the conversion of carminomyc

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=narcis______::ceba919bb99d9efbe3882f6e9ebdc4d8
https://research.rug.nl/en/publications/97f3907b-082f-40b6-9aa9-eaa98e90766d

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Carbon-11-labeled daunorubicin and verapamil for probing P-glycoprotein in tumors with PET

Autor: Elsinga, PH, Franssen, EJF, Hendrikse, NH, Fluks, L, Weemaes, AMA, vanderGraaf, WTA, deVries, GE, Visser, GM, Vaalburg, W

Publikováno v: Journal of Nuclear Medicine, 37(9), 1571-1575. SOC NUCLEAR MEDICINE INC

One of the mechanisms for multidrug resistance (MDR) of tumors is an overexpression of the P-glycoprotein (P-gp). The cytostatic agent daunorubicin and the modulator verapamil were labeled with C-11 to probe P-gp with PET. Methods: Carbon-11-daunorub

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=narcis______::a5f1417766f8fbff2433802cfc5c24d5
https://research.rug.nl/en/publications/8304e2fd-1184-4764-bec6-9e533ad96d39

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