Zobrazeno 1 - 10
of 11
pro vyhledávání: '"Hendrikje Werner"'
Autor:
Chia Yee Tan, Pui Shi Chan, Hansen Tan, Sung Wei Tan, Chang Jie Mick Lee, Jiong-Wei Wang, Shu Ye, Hendrikje Werner, Ying Jie Loh, Yin Loon Lee, Matthew Ackers-Johnson, Roger S. Y. Foo, Jianming Jiang
Publikováno v:
Journal of Translational Medicine, Vol 21, Iss 1, Pp 1-20 (2023)
Abstract Background Dilated cardiomyopathy (DCM) is a severe, non-ischemic heart disease which ultimately results in heart failure (HF). Decades of research on DCM have revealed diverse aetiologies. Among them, familial DCM is the major form of DCM,
Externí odkaz:
https://doaj.org/article/e04ecfd7269447468e9894f9eea45da8
Autor:
Ruth Jinfen Chai, Hendrikje Werner, Peter Yiqing Li, Yin Loon Lee, Khaing Thet Nyein, Irina Solovei, Tuan Danh Anh Luu, Bhavya Sharma, Raju Navasankari, Martina Maric, Lois Yu En Sim, Ying Jie Loh, Edita Aliwarga, Jason Wen Long Cheong, Alexandre Chojnowski, Matias Ilmari Autio, Yu Haiyang, Kenneth Kian Boon Tan, Choong Tat Keng, Shi Ling Ng, Wei Leong Chew, Michael Ferenczi, Brian Burke, Roger Sik Yin Foo, Colin L. Stewart
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-16 (2021)
Mutations in the LaminA gene are the second most common inherited cause of Dilated Cardiomyopathy, a major form of heart failure. Here the authors show that disruption of the nuclear protein SUN1 in cardiomyocytes, by AAV mediated transduction of a S
Externí odkaz:
https://doaj.org/article/c8e8b6f93e7b442686a2d1ede70d7399
Autor:
Yvonne Imielski, Jens C Schwamborn, Patrick Lüningschrör, Peter Heimann, Magdalena Holzberg, Hendrikje Werner, Oliver Leske, Andreas W Püschel, Sylvie Memet, Rolf Heumann, Alain Israel, Christian Kaltschmidt, Barbara Kaltschmidt
Publikováno v:
PLoS ONE, Vol 7, Iss 2, p e30838 (2012)
Cognitive decline during aging is correlated with a continuous loss of cells within the brain and especially within the hippocampus, which could be regenerated by adult neurogenesis. Here we show that genetic ablation of NF-κB resulted in severe def
Externí odkaz:
https://doaj.org/article/53857d67d18447c4942306c5225d5d8d
Autor:
Ei Leen Leong, Nyein Thet Khaing, Bruno Cadot, Wei Liang Hong, Serguei Kozlov, Hendrikje Werner, Esther Sook Miin Wong, Colin L Stewart, Brian Burke, Yin Loon Lee
Publikováno v:
Human molecular genetics.
Mutations in LMNA, the gene encoding A-type lamins, cause laminopathies—diseases of striated muscle and other tissues. The aetiology of laminopathies has been attributed to perturbation of chromatin organization or structural weakening of the nucle
Autor:
Alexandre Chojnowski, Colin L. Stewart, Lois Yu En Sim, Yin Loon Lee, Choong Tat Keng, Matias Ilmari Autio, Tuan Danh Anh Luu, Ying Jie Loh, Khaing Thet Nyein, Roger Foo, Michael A. Ferenczi, Brian Burke, Shi Ling Ng, Kenneth Kian Boon Tan, Bhavya Sharma, Irina Solovei, Yu Haiyang, Jason Wen Long Cheong, Ruth Jinfen Chai, Peter Yiqing Li, Edita Aliwarga, Raju Navasankari, Martina Maric, Hendrikje Werner, Wei Leong Chew
Publikováno v:
Nature Communications
Nature Communications, Vol 12, Iss 1, Pp 1-16 (2021)
Nature Communications, Vol 12, Iss 1, Pp 1-16 (2021)
Mutations in the LaminA gene are a common cause of monogenic dilated cardiomyopathy. Here we show that mice with a cardiomyocyte-specific Lmna deletion develop cardiac failure and die within 3–4 weeks after inducing the mutation. When the same Lmna
Autor:
Colin L. Stewart, Hendrikje Werner, Brian Burke, Radoslaw M. Sobota, Alexandre Chojnowski, Matthew Cook
Publikováno v:
Current Protocols in Cell Biology. 84
Protein-protein interactions (PPIs) add an essential layer of complexity to the information encoded by the genome. Modulation of such interactions is a key feature of most, if not all, cellular activities and allows cells to respond rapidly to both i
Autor:
Colin L. Stewart, Hendrikje Werner
Publikováno v:
Mechanisms of Development. 145:S95-S96
Publikováno v:
Journal of Biological Chemistry. 283:33784-33792
The development of polarized hippocampal neurons with a single axon and multiple dendrites depends on the activity of phosphoinositide 3-kinase (PI3K) and the GTPase Rap1B. Here we show that PI3K regulates axon specification and elongation through th
Autor:
Rolf Heumann, Andreas W. Püschel, Peter Heimann, Jens Christian Schwamborn, Alain Israël, Sylvie Mémet, Patrick Lüningschrör, Barbara Kaltschmidt, Oliver Leske, Christian Kaltschmidt, Magdalena Holzberg, Yvonne Imielski, Hendrikje Werner
Publikováno v:
PLoS ONE, Vol 7, Iss 2, p e30838 (2012)
PLoS ONE
PLoS ONE
Cognitive decline during aging is correlated with a continuous loss of cells within the brain and especially within the hippocampus, which could be regenerated by adult neurogenesis. Here we show that genetic ablation of NF-κB resulted in severe def
Autor:
Yvonne Imielski, Jens C. Schwamborn, Patrick Lüningschrör, Peter Heimann, Magdalena Holzberg, Hendrikje Werner, Oliver Leske, Andreas W. Püschel, Sylvie Memet, Rolf Heumann, Alain Israel, Christian Kaltschmidt, Barbara Kaltschmidt
Publikováno v:
Nature Precedings
Cognitive decline during aging is correlated with a continuous loss of cells within the brain and especially within the hippocampus, which could be regenerated by adult neurogenesis. Here we show that genetic ablation of NF-κB resulted in severe def
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=od_______984::1f034116c25cbf06bdc0875be5c49b00
http://precedings.nature.com/documents/6096/version/1
http://precedings.nature.com/documents/6096/version/1