Zobrazeno 1 - 10
of 22
pro vyhledávání: '"Hendrika M.A. VanDongen"'
Autor:
Hendrika M.A. VanDongen, Jiawen Huang, Youngmi Jung, Anna Mae Diehl, Liu Yang, Rafal P. Witek, Gianfranco Alpini, Steve S. Choi, Alessia Omenetti
Publikováno v:
Stem Cells. 26:2104-2113
Liver injury activates quiescent hepatic stellate cells (Q-HSC) to proliferative myofibroblasts. Accumulation of myofibroblastic hepatic stellate cells (MF-HSC) sometimes causes cirrhosis and liver failure. However, MF-HSC also promote liver regenera
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5839dc96c7c7fe2078814f7b5c953920
https://doi.org/10.1634/stemcells.2008-0115
https://doi.org/10.1634/stemcells.2008-0115
Autor:
Hendrika M.A. VanDongen, Susanne V Fleig, Liu Yang, Anna Mae Diehl, Steve S. Choi, Jiawen Huang, Jason K. Sicklick, Alessia Omenetti, Youngmi Jung
Publikováno v:
Laboratory Investigation. 87:1227-1239
Progenitors regenerate fatty livers but the mechanisms involved are uncertain. The Hedgehog pathway regulates mesendodermal progenitors and modulates mesenchymal-epithelial interactions during tissue remodeling. To determine if Hedgehog signaling inc
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ab31ff13083239ebaa43886cb19b5f49
https://doi.org/10.1038/labinvest.3700689
https://doi.org/10.1038/labinvest.3700689
Publikováno v:
Brain Research. 1153:20-33
Activity-regulated cytoskeleton-associated protein (Arc/Arg3.1) is an immediate early gene, whose expression in the central nervous system is induced by specific patterns of synaptic activity. Arc is required for the late-phase of long-term potentiat
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6ea8e49fd45f951d949433a7eabf71c5
https://doi.org/10.1016/j.brainres.2007.03.079
https://doi.org/10.1016/j.brainres.2007.03.079
Publikováno v:
The Journal of Neuroscience. 25:9488-9496
Abnormalities in dendritic spines have long been associated with cognitive dysfunction and neurodevelopmental delay, whereas rapid changes in spine shape underlie synaptic plasticity. The key regulators of cytoskeletal reorganization in dendrites and
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cd231f1f05dfa5a7fa853a9d5b2596b7
https://doi.org/10.1523/jneurosci.2450-05.2005
https://doi.org/10.1523/jneurosci.2450-05.2005
Publikováno v:
European Journal of Neuroscience. 21:1457-1468
Maintenance of synaptic plasticity requires protein translation. Because changes in synaptic strength are regulated at the level of individual synapses, a mechanism is required for newly translated proteins to specifically and persistently modify onl
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0e82c43e6b5d7462365217f6a4b821a5
https://doi.org/10.1111/j.1460-9568.2005.03999.x
https://doi.org/10.1111/j.1460-9568.2005.03999.x
Publikováno v:
The Journal of Neuroscience. 22:2044-2053
Ion channels alternate stochastically between two functional states, open and closed. This gating behavior is controlled by membrane potential or by the binding of neurotransmitters in voltage- and ligand-gated channels, respectively. Although much p
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c7e92762ab5da8efcc2214c9e40a11fe
https://doi.org/10.1523/jneurosci.22-06-02044.2002
https://doi.org/10.1523/jneurosci.22-06-02044.2002
Publikováno v:
Molecular Brain Research. 73:189-192
Alanine 714 of the NMDA receptor NR1 subunit resides in the glycine binding pocket. The Ala714Leu mutation substantially shifts glycine affinity, but here no effect on antagonism by DCK is detected. Ala714Leu is also found to limit the efficacy of a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f78ab4e2db0e2ee0211797d8d8238fdf
https://doi.org/10.1016/s0169-328x(99)00247-8
https://doi.org/10.1016/s0169-328x(99)00247-8
Publikováno v:
Journal of Biological Chemistry. 272:3532-3537
While attempting to map a central region in the M3-M4 linker of the N-methyl-D-aspartate receptor NR1 subunit, we found that mutation of a single position, Ala-714, greatly reduced the apparent affinity for glycine. Proximal N-glycosylation localized
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2389039f3e23eb8425d43d4abfccdd1c
https://doi.org/10.1074/jbc.272.6.3532
https://doi.org/10.1074/jbc.272.6.3532
Atomic distance estimates from disulfides and high-affinity metal-binding sites in a K+ channel pore
Publikováno v:
Biophysical Journal. 72(1):117-126
The pore of potassium channels is lined by four identical, highly conserved hairpin loops, symmetrically arranged around a central permeation pathway. Introduction of cysteines into the external mouth of the drk1 K channel pore resulted in the format
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e36d3e45c3e1639f8081485345a5ba6f
Publikováno v:
Proceedings of the National Academy of Sciences. 92:4882-4886
Single channel recordings demonstrate that ion channels switch stochastically between an open and a closed pore conformation. In search of a structural explanation for this universal open/close behavior, we have uncovered a striking degree of amino a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::56f8b40fdc5cc85e45f5df9aa5272c27
https://doi.org/10.1073/pnas.92.11.4882
https://doi.org/10.1073/pnas.92.11.4882