Výsledky vyhledávání - "Hendrik Modick"

Urinary metabolites of the UV filter octocrylene in humans as biomarkers of exposure

Autor: Daniel Bury, Thomas Brüning, Edgar Leibold, Holger M. Koch, Hendrik Modick-Biermann

Publikováno v: Archives of Toxicology. 93:1227-1238

Octocrylene (OC) is a UV filter used in sun screens and other personal care products, but also in polymers and food contact materials for stabilization. In this study, we investigate human OC metabolism and urinary excretion after oral dosage of appr

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bb321056ebe42c7917e8cd9af85c6999
https://doi.org/10.1007/s00204-019-02408-7

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Aniline Is Rapidly Converted Into Paracetamol Impairing Male Reproductive Development

Autor: Séverine Mazaud-Guittot, Benjamin A. H. Jensen, Kamil Borkowski, Lars Skovgaard Jensen, Clementine Chalmey, Tobias Weiss, Mette Marie Nørregård, Holger M. Koch, Bjarne Styrishave, Georg Dierkes, Jacob Bak Holm, Karsten Kristiansen, David Møbjerg Kristensen, Hendrik Modick, Bernard Jégou

Publikováno v: Toxicological Sciences
Toxicological Sciences, Oxford University Press (OUP), 2015, 148 (1), pp.288-298. ⟨10.1093/toxsci/kfv179⟩
Toxicological Sciences, 2015, 148 (1), pp.288-298. ⟨10.1093/toxsci/kfv179⟩

International audience; Industrial use of aniline is increasing worldwide with production estimated to surpass 5.6 million metric tons in 2016. Exposure to aniline occurs via air, diet and water augmenting the risk of exposing a large number of indiv

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a6572993e4d549aff8f02741a64f70dd
https://doi.org/10.1093/toxsci/kfv179

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Human metabolism and excretion kinetics of aniline after a single oral dose

Autor: Stephan Koslitz, Holger M. Koch, Tobias Weiss, Heiko U. Käfferlein, Thomas Brüning, Hendrik Modick, Georg Dierkes

Publikováno v: Archives of Toxicology. 90:1325-1333

Aniline is an important source material in the chemical industry (e.g., rubber, pesticides, and pharmaceuticals). The general population is known to be ubiquitously exposed to aniline. Thus, assessment of aniline exposure is of both occupational and

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::52893e154a5a745faa8de71965e5c5f8
https://doi.org/10.1007/s00204-015-1566-x

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N-Acetyl-4-aminophenol (paracetamol), N-acetyl-2-aminophenol and acetanilide in urine samples from the general population, individuals exposed to aniline and paracetamol users

Autor: Tobias Weiss, Holger M. Koch, Heiko U. Käfferlein, Hendrik Modick, Georg Dierkes, Thomas Brüning

Publikováno v: International Journal of Hygiene and Environmental Health. 217:592-599

Epidemiological studies suggest associations between the use of N-acetyl-4-aminophenol (paracetamol) during pregnancy and increased risks of reproductive disorders in the male offspring. Previously we have reported a ubiquitous urinary excretion of N

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::63b748fad220cf3afa0370effe41681e
https://doi.org/10.1016/j.ijheh.2013.11.005

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Rapid determination of N-acetyl-4-aminophenol (paracetamol) in urine by tandem mass spectrometry coupled with on-line clean-up by two dimensional turbulent flow/reversed phase liquid chromatography

Autor: Hendrik Modick, André Schütze, Tobias Weiss, Claudia Pälmke, Holger M. Koch, Thomas Brüning

Publikováno v: Journal of Chromatography B. 925:33-39

N -Acetyl-4-aminophenol (NAAP) is the major urinary metabolite of aniline. The general population is known to be ubiquitously exposed to aniline through various sources. Furthermore, NAAP, known under the trade name paracetamol (resp. acetaminophen),

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::58e8e551bdb0afa27a90f9c21a7e15e0
https://doi.org/10.1016/j.jchromb.2013.02.023

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A new colorimetric method to quantify β-1,3-1,6-glucans in comparison with total β-1,3-glucans in edible mushrooms

Autor: Jörg Nitschke, Hendrik Modick, Helga Mölleken, Hans-Josef Altenbach, Reimund Wantoch von Rekowski, Ekkehard Busch

Publikováno v: Food Chemistry. 127:791-796

Mushroom β-glucans are known for their activity as biological response modifiers and anticarcinogenic agents. β-1,3-1,6 Branched glucans with a triple helix tertiary structure are recognised as the most potent ones. In the present work, a colorimet

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a14732b7578f97c275e0e7cd82ef5685
https://doi.org/10.1016/j.foodchem.2010.12.149

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Additional oxidized and alkyl chain breakdown metabolites of the plasticizer DINCH in urine after oral dosage to human volunteers

Autor: Angelika Langsch, Hendrik Modick, Holger M. Koch, André Schütze, Thomas Brüning, Rainer Otter

Publikováno v: Archives of toxicology. 91(1)

Hexamoll® DINCH® (diisononyl-cyclohexane-1,2-dicarboxylate) is a new high molecular weight plasticizer and a non-aromatic phthalate substitute. In this follow-up study, we further investigated the extensive oxidative metabolism of Hexamoll® DINCH�

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0d9b9afe98677a4a0e2c370656d2c82b
https://pubmed.ncbi.nlm.nih.gov/26976210

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N-acetyl-4-aminophenol (paracetamol) in urine samples of 6-11-year-old Danish school children and their mothers

Autor: Holger M. Koch, Flemming Nielsen, Hendrik Modick, Jeanette K.S. Nielsen, Janne Fangel Jensen, Thit A. Mørck, Lisbeth E. Knudsen

Publikováno v: Nielsen, J K, Modick, H, Morck, T A, Jensen, J F, Nielsen, F, Koch, H M & Knudsen, L E 2015, ' N-acetyl-4-aminophenol (paracetamol) in urine samples of 6-11-year-old Danish school children and their mothers ', International Journal of Hygiene and Environmental Health, vol. 218, no. 1, pp. 28-33 . https://doi.org/10.1016/j.ijheh.2014.07.001

Recent studies indicate an association between the use of paracetamol during pregnancy and reproductive disorders in male offspring. Furthermore, N-acetyl-4-aminophenol (NAAP, paracetamol) has been shown to be ubiquitously excreted in urine samples o

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5a45ac254608aed2258051d4fa6e5733
https://pubmed.ncbi.nlm.nih.gov/25127489

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Ubiquitous presence of paracetamol in human urine: sources and implications

Autor: Hendrik Modick, Thomas Brüning, Holger M. Koch, Tobias Weiss, Georg Dierkes

Publikováno v: Reproduction (Cambridge, England). 147(4)

N-acetyl-4-aminophenol (acetaminophen/paracetamol, NA4AP) is one of the most commonly used over-the-counter analgesic and antipyretic drugs. Recent studies have reported anti-androgenic effects of NA4APin vitroand possible associations between intrau

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a0d2b2e8345bd63ee7f200067c27e191
https://pubmed.ncbi.nlm.nih.gov/24451225

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