Zobrazeno 1 - 10
of 72
pro vyhledávání: '"Hendrik Marks"'
Autor:
Mélanie Pailles, Mélanie Hirlemann, Vincent Brochard, Martine Chebrout, Jean-François Oudin, Hendrik Marks, Alice Jouneau, Amélie Bonnet-Garnier
Publikováno v:
Scientific Reports, Vol 12, Iss 1, Pp 1-15 (2022)
Abstract Early mouse development is characterized by structural and epigenetic changes while cells progress towards differentiation. At blastocyst stage, the segregation of the three primordial lineages is accompanied by establishment of differential
Externí odkaz:
https://doaj.org/article/8839745398a9417491cf2809d282041c
Autor:
Tianran Peng, Yanan Zhai, Yaser Atlasi, Menno ter Huurne, Hendrik Marks, Hendrik G. Stunnenberg, Wout Megchelenbrink
Publikováno v:
Genome Biology, Vol 21, Iss 1, Pp 1-27 (2020)
Abstract Background Enhancers are distal regulators of gene expression that shape cell identity and control cell fate transitions. In mouse embryonic stem cells (mESCs), the pluripotency network is maintained by the function of a complex network of e
Externí odkaz:
https://doaj.org/article/a7e5bc5ab6f847d9aaa8ed8f93c3acaf
Autor:
Emma Bell, Edward W. Curry, Wout Megchelenbrink, Luc Jouneau, Vincent Brochard, Rute A. Tomaz, King Hang T. Mau, Yaser Atlasi, Roshni A. de Souza, Hendrik Marks, Hendrik G. Stunnenberg, Alice Jouneau, Véronique Azuara
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-16 (2020)
Clusters of enhancers, called super-enhancers (SEs), control the expression of cell identity genes. Here, the authors identify two types of enhancer units within SEs in ESCs, characterised by distinctive CpG methylation dynamics, and find that ESRRB
Externí odkaz:
https://doaj.org/article/5299ca445e9743b2869fc3fe2a1a17ce
Autor:
Menno ter Huurne, Tianran Peng, Guoqiang Yi, Guido van Mierlo, Hendrik Marks, Hendrik G. Stunnenberg
Publikováno v:
Stem Cell Reports, Vol 14, Iss 2, Pp 175-183 (2020)
Summary: Mouse embryonic stem cells (ESCs) grown in serum-supplemented conditions are characterized by an extremely short G1 phase due to the lack of G1-phase control. Concordantly, the G1-phase-specific P53-P21 pathway is compromised in serum ESCs.
Externí odkaz:
https://doaj.org/article/c34d3da9991040b2b6484a63cb6542cf
Autor:
Floris J. M. Roos, Haoyu Wu, Jorke Willemse, Ruby Lieshout, Laura A. Muñoz Albarinos, Yik‐Yang Kan, Jan‐Werner Poley, Marco J. Bruno, Jeroen deJonge, Richard Bártfai, Hendrik Marks, Jan N. M. IJzermans, Monique M. A. Verstegen, Luc J. W. van derLaan
Publikováno v:
Clinical and Translational Medicine, Vol 11, Iss 12, Pp n/a-n/a (2021)
Abstract The well‐established 3D organoid culture method enabled efficient expansion of cholangiocyte‐like cells from intrahepatic (IHBD) and extrahepatic bile duct (EHBD) tissue biopsies. The extensive expansion capacity of these organoids enabl
Externí odkaz:
https://doaj.org/article/5038a580033647ada1c8ec4149e058fa
Autor:
Cristina Furlan, René A. M. Dirks, Peter C. Thomas, Robert C. Jones, Jing Wang, Mark Lynch, Hendrik Marks, Michiel Vermeulen
Publikováno v:
Nature Communications, Vol 10, Iss 1, Pp 1-8 (2019)
Affinity purification-mass spectrometry (AP-MS) can identify endogenous protein interactions but the need for high amounts of input material still limits its applicability. Here, the authors present a microfluidic-based AP-MS workflow that can captur
Externí odkaz:
https://doaj.org/article/b0ab23fc21264551ba1dea982ce9a0d1
Allele-specific RNA-seq expression profiling of imprinted genes in mouse isogenic pluripotent states
Autor:
René A. M. Dirks, Guido van Mierlo, Hindrik H. D. Kerstens, Andreia S. Bernardo, Julianna Kobolák, István Bock, Julien Maruotti, Roger A. Pedersen, András Dinnyés, Martijn A. Huynen, Alice Jouneau, Hendrik Marks
Publikováno v:
Epigenetics & Chromatin, Vol 12, Iss 1, Pp 1-21 (2019)
Abstract Background Genomic imprinting, resulting in parent-of-origin specific gene expression, plays a critical role in mammalian development. Here, we apply allele-specific RNA-seq on isogenic B6D2F1 mice to assay imprinted genes in tissues from ea
Externí odkaz:
https://doaj.org/article/ccab5f203e284c20b12ae65e88095907
Publikováno v:
Stem Cell Research, Vol 33, Iss , Pp 135-145 (2018)
The ground state of pluripotency is defined as a minimal unrestricted epigenetic state as present in the Inner Cell Mass. Mouse embryonic stem cells (ESCs) grown in a defined serum-free medium with two kinase inhibitors (“2i ESCs”) have been post
Externí odkaz:
https://doaj.org/article/6190e8a159ec4c3db3391450e6862150
Autor:
Andreia S. Bernardo, Alice Jouneau, Hendrik Marks, Philip Kensche, Julianna Kobolak, Kristine Freude, Vanessa Hall, Anita Feher, Zsuzsanna Polgar, Chiara Sartori, Istvan Bock, Claire Louet, Tiago Faial, Hindrik H. D. Kerstens, Camille Bouissou, Gregory Parsonage, Kaveh Mashayekhi, James C. Smith, Giovanna Lazzari, Poul Hyttel, Hendrik G. Stunnenberg, Martijn Huynen, Roger A. Pedersen, Andras Dinnyes
Publikováno v:
Biology Open, Vol 7, Iss 8 (2018)
During early mammalian development, transient pools of pluripotent cells emerge that can be immortalised upon stem cell derivation. The pluripotent state, ‘naïve’ or ‘primed’, depends on the embryonic stage and derivation conditions used. He
Externí odkaz:
https://doaj.org/article/c7dcadce61d94f648a649a416ee01f36
Autor:
Shen-Hsi Yang, Tüzer Kalkan, Claire Morissroe, Hendrik Marks, Hendrik Stunnenberg, Austin Smith, Andrew D. Sharrocks
Publikováno v:
Cell Reports, Vol 7, Iss 6, Pp 1968-1981 (2014)
Embryonic stem cells (ESCs) are unique in that they have the capacity to differentiate into all of the cell types in the body. We know a lot about the complex transcriptional control circuits that maintain the naive pluripotent state under self-renew
Externí odkaz:
https://doaj.org/article/5d756686d44647c4b90b13749a5d7b2c