Zobrazeno 1 - 10
of 70
pro vyhledávání: '"Hendrik Jan, Thibaut"'
Autor:
Li-Hsin Li, Winston Chiu, Yun-An Huang, Madina Rasulova, Thomas Vercruysse, Hendrik Jan Thibaut, Sebastiaan ter Horst, Joana Rocha-Pereira, Greet Vanhoof, Doortje Borrenberghs, Olivia Goethals, Suzanne J. F. Kaptein, Pieter Leyssen, Johan Neyts, Kai Dallmeier
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-15 (2024)
Abstract To curb viral epidemics and pandemics, antiviral drugs are needed with activity against entire genera or families of viruses. Here, we develop a cell-based multiplex antiviral assay for high-throughput screening against multiple viruses at o
Externí odkaz:
https://doaj.org/article/883693f5cd604c2dad6b91f11a0839d3
Autor:
Viktor Lemmens, Lara Kelchtermans, Sarah Debaveye, Winston Chiu, Thomas Vercruysse, Ji Ma, Hendrik Jan Thibaut, Johan Neyts, Lorena Sanchez-Felipe, Kai Dallmeier
Publikováno v:
npj Vaccines, Vol 8, Iss 1, Pp 1-12 (2023)
Abstract Ebola virus (EBOV) and related filoviruses such as Sudan virus (SUDV) threaten global public health. Effective filovirus vaccines are available only for EBOV, yet restricted to emergency use considering a high reactogenicity and demanding lo
Externí odkaz:
https://doaj.org/article/6df8991fb9124a22ae07f96ee394ac98
Autor:
Sven Göbel, Ozeir Kazemi, Ji Ma, Ingo Jordan, Volker Sandig, Jasmine Paulissen, Winnie Kerstens, Hendrik Jan Thibaut, Udo Reichl, Kai Dallmeier, Yvonne Genzel
Publikováno v:
Vaccines, Vol 12, Iss 7, p 755 (2024)
The live-attenuated yellow fever 17D strain is a potent vaccine and viral vector. Its manufacture is based on embryonated chicken eggs or adherent Vero cells. Both processes are unsuitable for rapid and scalable supply. Here, we introduce a high-thro
Externí odkaz:
https://doaj.org/article/d385ae36784941d09b97f2c28e5ae1cd
Autor:
Sapna Sharma, Thomas Vercruysse, Lorena Sanchez-Felipe, Winnie Kerstens, Madina Rasulova, Lindsey Bervoets, Carolien De Keyzer, Rana Abdelnabi, Caroline S. Foo, Viktor Lemmens, Dominique Van Looveren, Piet Maes, Guy Baele, Birgit Weynand, Philippe Lemey, Johan Neyts, Hendrik Jan Thibaut, Kai Dallmeier
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-11 (2022)
Currently licensed COVID-19 vaccines are based on antigen sequences of early SARS-CoV-2 isolates, despite the prevalence of variants of concerns escaping vaccine-mediated protection. Using their updated yellow fever 17D vectored candidate, here, auth
Externí odkaz:
https://doaj.org/article/4924ff2c0d8d4311b6386793aa74eaa2
Autor:
Rana Abdelnabi, Patricia Pérez, David Astorgano, Guillermo Albericio, Winnie Kerstens, Hendrik Jan Thibaut, Lotte Coelmont, Birgit Weynand, Nuria Labiod, Rafael Delgado, Dolores Montenegro, Eugenia Puentes, Esteban Rodríguez, Johan Neyts, Kai Dallmeier, Mariano Esteban, Juan García-Arriaza
Publikováno v:
Frontiers in Immunology, Vol 14 (2023)
The development of novel optimized vaccines against coronavirus disease 2019 (COVID-19) that are capable of controlling the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) pandemic and the appearance of different variants of concern (VoC
Externí odkaz:
https://doaj.org/article/68157076a75c4c40a3009c48ca5bfe3a
Autor:
Li-Hsin Li, Laurens Liesenborghs, Lanjiao Wang, Marleen Lox, Michael Bright Yakass, Sander Jansen, Ana Lucia Rosales Rosas, Xin Zhang, Hendrik Jan Thibaut, Dirk Teuwen, Johan Neyts, Leen Delang, Kai Dallmeier
Publikováno v:
Molecular Therapy: Methods & Clinical Development, Vol 25, Iss , Pp 215-224 (2022)
New platforms are needed for the design of novel prophylactic vaccines and advanced immune therapies. Live-attenuated yellow fever vaccine YF17D serves as a vector for several licensed vaccines and platform for novel candidates. On the basis of YF17D
Externí odkaz:
https://doaj.org/article/667a0070a8ac4afca77e33931e73cdb7
Autor:
Ji Ma, Michael Bright Yakass, Sander Jansen, Bert Malengier-Devlies, Dominique Van Looveren, Lorena Sanchez-Felipe, Thomas Vercruysse, Birgit Weynand, Mahadesh Prasad Arkalagud Javarappa, Osbourne Quaye, Patrick Matthys, Tania Roskams, Johan Neyts, Hendrik Jan Thibaut, Kai Dallmeier
Publikováno v:
EBioMedicine, Vol 83, Iss , Pp 104240- (2022)
Summary: Background: The live-attenuated yellow fever vaccine YF17D holds great promise as alternative viral vector vaccine platform, showcased by our previously presented potent severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) vaccine ca
Externí odkaz:
https://doaj.org/article/270dca2fe4d84600b4955f812e5c5bb0
Autor:
Maya Imbrechts, Wim Maes, Louanne Ampofo, Nathalie Van den Berghe, Bas Calcoen, Dominique Van Looveren, Winnie Kerstens, Madina Rasulova, Thomas Vercruysse, Sam Noppen, Rana Abdelnabi, Caroline Foo, Kevin Hollevoet, Piet Maes, Xin Zhang, Dirk Jochmans, Karen Ven, Jeroen Lammertyn, Karen Vanhoorelbeke, Nico Callewaert, Paul De Munter, Dominique Schols, Hendrik Jan Thibaut, Johan Neyts, Paul Declerck, Nick Geukens
Publikováno v:
iScience, Vol 25, Iss 8, Pp 104705- (2022)
Summary: Treatment with neutralizing monoclonal antibodies (mAbs) against severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) contributes to COVID-19 management. Unfortunately, SARS-CoV-2 variants escape several of these recently approved mA
Externí odkaz:
https://doaj.org/article/62ab4071a18b4ac48377864e5ae28caf
Autor:
Madina Rasulova, Thomas Vercruysse, Jasmine Paulissen, Catherina Coun, Vanessa Suin, Leo Heyndrickx, Ji Ma, Katrien Geerts, Jolien Timmermans, Niraj Mishra, Li-Hsin Li, Dieudonné Buh Kum, Lotte Coelmont, Steven Van Gucht, Hadi Karimzadeh, Julia Thorn-Seshold, Simon Rothenfußer, Kevin K. Ariën, Johan Neyts, Kai Dallmeier, Hendrik Jan Thibaut
Publikováno v:
Microbiology Spectrum, Vol 10, Iss 3 (2022)
ABSTRACT Quick and accurate detection of neutralizing antibodies (nAbs) against yellow fever is essential in serodiagnosis during outbreaks for surveillance and to evaluate vaccine efficacy in population-wide studies. All of this requires serological
Externí odkaz:
https://doaj.org/article/61bcd96f42ef42ad9b0ace605b4b0c42
Autor:
Ji Ma, Robbert Boudewijns, Lorena Sanchez-Felipe, Niraj Mishra, Thomas Vercruysse, Dieudonné Buh Kum, Hendrik Jan Thibaut, Johan Neyts, Kai Dallmeier
Publikováno v:
Emerging Microbes and Infections, Vol 10, Iss 1, Pp 2279-2290 (2021)
The live-attenuated yellow fever 17D (YF17D) vaccine is one of the most efficacious human vaccines and also employed as a vector for novel vaccines. However, in the lack of appropriate immunocompetent small animal models, mechanistic insight in YF17D
Externí odkaz:
https://doaj.org/article/cbeaf788d7754508ab04743ef8ddbea9