Zobrazeno 1 - 7
of 7
pro vyhledávání: '"Hendrik J. Engelenburg"'
Autor:
Aletta M. R. van den Bosch, Marlijn van der Poel, Nina L. Fransen, Maria C. J. Vincenten, Anneleen M. Bobeldijk, Aldo Jongejan, Hendrik J. Engelenburg, Perry D. Moerland, Joost Smolders, Inge Huitinga, Jörg Hamann
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-16 (2024)
Abstract Microglia nodules (HLA-DR+ cell clusters) are associated with brain pathology. In this post-mortem study, we investigated whether they represent the first stage of multiple sclerosis (MS) lesion formation. We show that microglia nodules are
Externí odkaz:
https://doaj.org/article/598c1f7d0a794ef3b7096efd7cbff052
Autor:
Laurens Bogers, Hendrik J. Engelenburg, Malou Janssen, Peter-Paul A. Unger, Marie-José Melief, Annet F. Wierenga-Wolf, Cheng-Chih Hsiao, Matthew R.J. Mason, Jörg Hamann, Jamie van Langelaar, Joost Smolders, Marvin M. van Luijn
Publikováno v:
EBioMedicine, Vol 89, Iss , Pp 104465- (2023)
Summary: Background: Although distinct brain-homing B cells have been identified in multiple sclerosis (MS), it is unknown how these further evolve to contribute to local pathology. We explored B-cell maturation in the central nervous system (CNS) of
Externí odkaz:
https://doaj.org/article/ab5257161bc347f88c384c428b46a61f
Autor:
Cheng-Chih Hsiao, Hendrik J. Engelenburg, Aldo Jongejan, Jing Zhu, Baohong Zhang, Michael Mingueneau, Perry D. Moerland, Inge Huitinga, Joost Smolders, Jörg Hamann
Publikováno v:
iScience, Vol 26, Iss 1, Pp 105785- (2023)
Summary: The human brain is populated by perivascular T cells with a tissue-resident memory T (TRM)-cell phenotype, which in multiple sclerosis (MS) associate with lesions. We investigated the transcriptional and functional profile of freshly isolate
Externí odkaz:
https://doaj.org/article/ea87777100934dbb94daef45591458fe
Publikováno v:
Evolution, Medicine, and Public Health. 10:277-294
Multiple sclerosis (MS), a neurological autoimmune disorder, has recently been linked to neuro-inflammatory influences from the gut. In this review, we address the idea that evolutionary mismatches could affect the pathogenesis of MS via the gut micr
Autor:
Kitty Reemst, Nicola Lopizzo, Maralinde R. Abbink, Hendrik J. Engelenburg, Annamaria Cattaneo, Aniko Korosi
Early-life stress (ELS) exposure increases the risk for mental disorders, including cognitive impairments later in life. We have previously demonstrated that a dietary low ω6/ω3 polyunsaturated fatty acid (PUFA) ratio protects against ELS-induced c
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::53fcb974cf545d8043a9713b4c987888
https://doi.org/10.1101/2022.08.06.503026
https://doi.org/10.1101/2022.08.06.503026
Autor:
Ester B. M. Remmerswaal, Hendrik J Engelenburg, Marlijn van der Poel, Nina L. Fransen, Joost Smolders, Matthew R. J. Mason, Kim Verdaasdonk, Maria C J Vincenten, Jörg Hamann, Tanja Kuhlmann, Cheng-Chih Hsiao, Inge Huitinga
Publikováno v:
Brain, 143(6), 1714-1730. Oxford University Press
Brain, 143, 1714-1730. Oxford University Press
Brain, 143, 1714-1730. Oxford University Press
Multiple sclerosis is a chronic inflammatory, demyelinating disease, although it has been suggested that in the progressive late phase, inflammatory lesion activity declines. We recently showed in the Netherlands Brain Bank multiple sclerosis-autopsy
Publikováno v:
Evolution, medicine, and public health. 10(1)
Multiple sclerosis (MS), a neurological autoimmune disorder, has recently been linked to neuro-inflammatory influences from the gut. In this review, we address the idea that evolutionary mismatches could affect the pathogenesis of MS via the gut micr